| Project/Area Number |
10470200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
NUMACHI Yohtaro Tohoku University Hospital, Lecturer, 医学部附属病院, 講師 (00261636)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Mitsumoto Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70033321)
沼知 寿美子 (吉田 寿美) 東北大学, 医学部, 助手 (50261532)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | stimulant-induced psychosis / reverse tolerance / tyrosine kinase / methamphetamine / neuronal plasticity / メタンフェタミン |
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| Research Abstract |
Among catecholaminergic agonist, methamphetamine (MAP) is the most abused drug in Japan. MAP causes a severe psychotic state which resembles schizophrenia (Sato, Numachi, 1992). Because vulnerability to relapse in MAP-induced psychosis lasts for a long time, enduring changes in neural function is expected to underlie MAP psychosis. Reverse tolerance phenomenon, observed in MAP-treated animals, provides a good animal model for MAP psychosis as well as schizophrenia (Numachi, 1998).
By collaboration with Dr. T. Nishikawa (NCNP, Japan) we found that mRNA for rEphA7, one of receptor tyrosine kinases' family, increased in rat brain by acute MAP treatment, using RNA arbitrary-primed PCR method. rEphA7 plays an important role in axonal guidance and synaptic reorganization in brain. To clarify if abnormal synapse formation, related to reverse tolerance, is induced by MAP via rEphA7, we examined brain expression of rEphA7 in brain of MAP-treated rats using in situ hybridization. So far we observed mRNA for rEphA6 is increased in rat prefrontal cortex by MAP.
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