| Project/Area Number |
10470257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ARII Shigeli (1999) Kyoto University, First Dept. of Surgery, 医学研究科, 助教授 (50151171)
古谷 正晴 (1998) 京都大学, 医学研究科, 助手 (50293858)
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| Co-Investigator(Kenkyū-buntansha) |
KAIDO Loshimi Kyoto University, First Dept. of Surgery, 医学研究科, 助手 (80314194)
IMAMURA Masajuki Kyoto University, First Dept. of Surgery, 医学研究科, 教授 (00108995)
有井 滋樹 京都大学, 医学研究科, 助教授 (50151171)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 1999: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1998: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | invasion / metastasis / kan-1 / gankyrin / UEGF / MMP / Rho / HME / 浸潤・転移 / 分子標的 / Signal sequence trap / MME / rho |
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| Research Abstract |
The most important factor for prognosis of cancer patients is invasion and metastasis of cancers. In the present study, we attempted to clarify the molecules responsible for cancer metastasis, and to establish a novel strategy against this disease by manipulating the expression of these molecules.
We obtained the interesting results as follows.
1) We discovered a new gene, Kan-1 which is expressed specifically in the liver and is a novel prognostic indicator for hepatocellular cancer patients.
2) We discovered a novel protein, gankyrin which suppresses Rb protein and overexpresses in hepatocellular carcinoma.
3) We clarified that VEGF(vascular endothelial growth factor) , MMP family, Rho, HME(human metalloelastase)are participated in invasion and metastasis of cancers by studying the human materials.
4) We clarified the significance of VEGF in the cancer growth and metastasis by establishing a stable clones transfected with VEGFcDNA.
5) We clarified a effect of MMP inhibitor in cancer metastasis.
6) We clarified that gene therapy by using soluble Flt-1expression vector is effective against peritoneal dissemination of cancer.
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