| Project/Area Number |
10470280
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center |
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Principal Investigator |
TAENAKA Yoshiyuki National Cardiovascular Center, Department of Artificial Organs, Director, 人工臓器部, 部長 (00142183)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEWA Yoshiaki National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (20332405)
TATSUMI Eisuke National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (00216996)
TSUKIYA Tomonori National Cardiovascular Center, Department of Artificial Organs, Staff, 人工臓器部, 室員 (00311449)
TAKANO Hisateru National Cardiovascular Center, Vice Director, 研究所, 副所長 (60028595)
中村 真人 東京医科歯科大学, 助教授 (90301803)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | nonpulsatile circulation / Aorta / Circulatory control / Circadian rhythm / Chronomedicine / Vascular tonus / Autonomic nerve / Peripheral vessels / 人工心臓 / 生体適合化 / 血液破壊 / 流れの可視化 / 数値解析法 / 血栓形成 / 解剖学的適合性 / 電磁波 / 人工循環 / 無拍動流循環 / 循環調節 / 血管トーヌス / 血管収縮性 / 末梢循環 |
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| Research Abstract |
Influences of mid-to-long term nonpulsatile circulation on function and structure of the living body were investigated especially in systemic circulation. Systemic vascular resistance was slightly decreased but other hemodynamics, peripheral organ, circulation, tissue metabolism and humoral circulatory control were not affected. Vascular tonus was maintained although constrictive function of the vascular system was reduced. Autonomic nervous sytem was also investigated. Circadian rhythm was well maintained except for rennin rhythm. Aortic wall thickness was reduced and atrophic changes of the wall smooth muscle cell was observed. Middle size arteries was not influence but peripheral vessels around the juxta-glommerular apparatus showed proliferation in the kidney.
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