| Project/Area Number |
10470297
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KAJIMOTO Yoshinaga Faculty of Medicine, Osaka Medical College, Assistant Professor, 医学部, 講師 (30224413)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Hiroji Faculty of Medicine, Osaka Medical College, Assistant Professor, 脳神経外科, 講師 (50181996)
OHTA Tomio Faculty of Medicine, Osaka Medical College, Professor, 脳神経外科, 教授 (80025650)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | hydrocephalus / vetriculoperitoneal shunt / intracranial pressure / intra-abdominal pressure / シャント治療 / オーバードレナージ / シャント機能不全 |
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| Research Abstract |
To evaluate the pressure environment of the shunt system in the human body, we measured the intracranial pressure (ICP), intra-abdominal pressure (IAP), and hydrostatic pressure of the shunt system in supine and sitting position. The increase in IAP and decrease in ICP offset the siphoning effect in the sitting position. The preferable ICP is estimated between -15 and -20 mmHg in the sitting position.
The volume load of autologos CSF of 3ml causes the increase in ICP and the intracranial elastance can be calculated from the pressure change (serial bolus injection method). We elucidated the pressure-elastance relationship of wide range of ICP using this method. In the normal range of ICP low elastance area with single valley in the supine position and double valleys in the sitting position was seen. In the high ICP its elevation rate was decelerated. The low elastance circumstance is seemed to be the goal of shunt therapy because the ICP becomes actable in the low elastance.
We measured intracranial oxygenation, oxy-b, deoxyHb, and brain oxygenation additionally. In the NPH patients, slight increase in ICP caused the decrement of oxyHb and brain oxygenation. This finding is very important for pathogenesis of NPH.
These findings suggested that the ICP, intracranial elastance, and brain oxygenation seems to become a good indicator of the shunt therapy.
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