| Project/Area Number |
10470299
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
MINAMI Akio Hokkaido Univ. Grad. School of Med., Prof., 大学院・医学研究科, 教授 (20133738)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Norimasa Hokkaido Univ. Grad. School of Med., Inst., 大学院・医学研究科, 助手 (30322803)
ITO Manabu Hokkaido University Medical Hospital, Inst., 医学部・附属病院, 助手 (00271677)
SUENAGA Noaki Hokkaido University Medical Hospital, Inst., 医学部・附属病院, 助手 (70261310)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2000: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1999: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | allogeneic joint transplantation / allogeneic limb transplantation / FK 506 / immunosuppression / time depency / 主要組織適合抗原 / 免疫抑制剤 |
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| Research Abstract |
(1) This study suggests that major histocompatibility complex (MHC) matching clearly improves the survival time of allotransplanted limb in rats. Specifically, both RT1-A and D matching is the most effective compatibility in prolonging survival time of allogeneic limb transplantations.
(2) In this study, we clarified the optimal timing of FK 506 administration for preventing allograft rejection of the limb. The mean graft survival time was 9 days in no treatment group, 19 days in day 0 group (FK506 5 mg/kg single i.m. at postop. 0 day), 52 days in day 1 group (FK 506 5 mg/kg single i.m. at postop. 1 day), 42 days in day 2 group (FK 506 5 mg/kg single i.m. at postop. 2 day). Histologically, all tissues showed significantly better preservation in day 1 and day 2 groups. On the basis of the current results, the administration of FK 506 for limb allograft is more effective at 1 or 2 days after tranplantation.
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