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Disialosyl galactosyl globoside as an adhesion molecule expressed on renal and lung cancer cells and its relationship to adrenal gland metastatic potential

Research Project

Project/Area Number 10470329
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTohoku University

Principal Investigator

SATOH Makoto  Tohoku University, Graduate School of Med, Research Associate, 大学院・医学系研究科, 助手 (70282134)

Co-Investigator(Kenkyū-buntansha) SAITO Seiichi  Tohoku University, Graduate School of Med, Research Associate, 医学部附属病院, 助手 (80235043)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsRenal Cell Carcinoma / Lung Cancer Cell / Adrenal Metastasis / Disialosyl Galactosylgloboside / ヒト腎癌 / DSGG / MSGG / GEM / ヒト肺腺癌 / 接着分子 / 腎癌細胞 / 肺癌細胞 / 肺転移
Research Abstract

1)Adrenal metastasis from renal cell carcinoma : significance of adrenalectomy :
Adrenal metastases were investigated in 256 patients with RCC undergone nephrectomy from 1977 to 1996 in Tohoku University Hospital. The risk of adrenal metastasis did not correlate with T classification, grade, and tumor location. The adrenal gland was thought to be a "fertile soil" for spread of renal cell carcinoma. (Int J Urol. under revision)
2)Establishment of 4 new human renal cell carcinoma cell lines expressing globo-series ganglioside:
TOS-1, TOS-2, TOS-3 and TOS-3LN cell lines derived from human RCC tissues were established. These cell lines showed different expression pattern of globo-series ganglioside. (Tohoku J Exp Medicine : 189,95-105,1999.)
3)Association of renal cell carcinoma (RCC) antigen, disialylgalactosylgloboside (DSGG), with c-Src and Rho A in clustered domains at the surface membrane :
DSGG is clustered in RCC to form a microdomain in which it is closely associated with c-Src, Rho A and FAK and may constitute a functional unit. The functional organization of such units may be essential in determining malignant properties of RCC cells. (Int J Oncol : 16,529-536,2000.)
4)DSGG mediates adhesion of RCC and lung cancer cells to certain adrenal medulla target cells :
DSGG expressed RCC or lung cancer cell lines showed strong adhesion to adrenal gland tissues. This adhesion process may initiate preferential adrenal metastasis.
(IGAKU NO AYUMI : 194, 841-844,2000)

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All 2000 1999 Other

All Journal Article (8 results) Publications (2 results)

  • [Journal Article] 腎癌に発現する肺転移関連分子DSGG2000

    • Author(s)
      佐藤 信
    • Journal Title

      医学のあゆみ 194号

      Pages: 841-844

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Association of renal cell carcinoma antigen, disialylgalactosylgloboside, with c-Src and RhoA in clustered domains at the surface membrane.2000

    • Author(s)
      Satoh M., et al.
    • Journal Title

      International Journal of Oncology 16

      Pages: 529-536

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] DSGG as an adhesion molecule expressed on renal cell carcinoma2000

    • Author(s)
      Satoh M
    • Journal Title

      IGAKU NO AYUMI 194

      Pages: 841-844

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Association of renal cell carcinoma antigen, disialylgalactosylgloboside, with c-Src and RhoA in clustered domains at the surface membrane.2000

    • Author(s)
      Satoh M., Nejad F M., Ohtani H., Ito A., Ohyama C., Saito S., Orikasa S., Hakomori S
    • Journal Title

      Int J Oncol 16

      Pages: 529-526

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Four new human renal cell carcinoma cell lines expressing globo-series gangliosides.1999

    • Author(s)
      Satoh M., et al.
    • Journal Title

      TOHOKU J EXP MED 189

      Pages: 95-105

    • NAID

      10013374139

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Four new human renal cell carcinoma cell lines expressing globo-series gangliosides.1999

    • Author(s)
      Satoh M., Nejad F M., Nakano O., Ito A., Kawamura S., Ohyama C., Saito S, Orikasa S
    • Journal Title

      TOHOKU J EXP MED 189

      Pages: 95-105

    • NAID

      10013374139

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Adrenal metastasis from renal cell carcinoma : significance of adrenalectomy.

    • Author(s)
      Ito A., Satoh M., et al.
    • Journal Title

      International Journal of Urology (in press)

    • NAID

      50000571077

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Journal Article] Adrenal metastasis from renal cell carcinoma : significance of adrenalectomy.

    • Author(s)
      Ito A., Satoh M., Ohyama C., Saito S., Shintaku I., Nakano O., Hoshi S, Orikasa S
    • Journal Title

      Int J Urol (in press)

    • NAID

      50000571077

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Makoto Satoh et al.: "Four new human renal cell carcinoma cell lines expressing globo-series gangliosides"Tohoku J. Exp. Med.. 189. 95-105 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Makoto Satoh et al.: "Association of renal cell carcinoma antigen, disialosylgalactosylgloboside, with c-Src and Rho A In clustered domains at the surface membrane"Int J Oncol. (In print).

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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