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Molecular genetic analysis of preeclampsia

Research Project

Project/Area Number 10470341
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tsukuba

Principal Investigator

KUBO Takeshi  Institute of Clinical Medicine, University of Tsukuba Professor, 臨床医学系, 教授 (20010267)

Co-Investigator(Kenkyū-buntansha) HAMADA Hiromi  Institute of Clinical Medicine, University of Tsukuba Assistant Professor, 臨床医学系, 講師 (60261799)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 1999: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1998: ¥7,600,000 (Direct Cost: ¥7,600,000)
Keywordspreeclampsia / multifactorial inheritance / gene polymorphism / candidate gene / plasminogen activator inhibitor-1 / methylenetetrahydrofolate reductase / Nitric Oxide Synthetase
Research Abstract

Preeclampsia contributes to maternal and fetal morbidity and mortality. Causal factors include environmental and inherited components. In this study, we assessed the association between preeclampsia and polymorphisms of the genes that are presumed to be candidate. The polymorphisms analyzed were the 677C/T of the methylenetetrahydrofolate reductase (MTHFR) gene, the 4G/5G of the plasminogen activator inhibitor-1 (PAI-1) gene, the 894G/T and -786T/C of the endothelial nitric oxide synthase gene, the -6G/A of the angiotensinogen gene, the 1691G/A of the blood coagulation factor V gene, and the 20210G/A of the prothrombin gene.
The frequency of the homozygotes for the 4G allele of the PAI-1 gene was significantly higher in the patients than in the control pregnant women (p=0.04) or in the healthy volunteers (p=0.02). The 4G allele frequency was also significantly more frequent in the patients than in the control group (p=0.03) and the healthy volunteers group (p=0.02). The genotype homozygous for T677 allele and the T677 allele were significantly increased in the preeclamptic group compared with the control group (p=0.02 and p=0.03, respectively), and compared with the healthy volunteers group (p=0.004 and p=0.02, respectively). There were no associations between preeclampsia and the other gene polymorphisms.
Our results suggest that the 4G allele of the PAI-1 gene and the T677 allele of the MTHFR gene are genetic risk factors for preeclampsia.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yamada N.,Arinami T.,Hamada H.,Kubo T.et al.: "The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia"Journal of Human Genetics. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamada N, Arinami T, Yamakawa-Kobayashi K, Sohda S, Hamada H, Kubo T, Hamaguchi H: "The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia."Journal of Human Genetics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamada N,Arinami T,Hamada H,Kubo T, et al.: "The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia"Journal of Human Genetics. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山田直樹,濱田洋実,他: "内皮型一酸化窒素合成酵素遺伝子多型と妊娠中毒症" 日本妊娠中毒症学会雑誌. 6(in press). (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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