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Morphologic and Electrophysiologic Study of Retinal Pigment Epithelial Cell Transplantation in Age-Related Macular Degeneration

Research Project

Project/Area Number 10470367
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionToho University

Principal Investigator

TAKEUCHI Shinobu  Toho University, School of Medicine, Professor, 医学部, 教授 (10082281)

Co-Investigator(Kenkyū-buntansha) MITAMURA Yoshinori  Toho University, School of Medicine, Assistant, 医学部, 助手 (30287536)
YAMAMOTO Teiko  Toho University, School of Medicine, Assistant Professor, 医学部, 講師 (00297706)
YAMAMOTO Shuichi  Toho University, School of Medicine, Associate Professor, 医学部, 助教授 (20230550)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 2000: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsAge-related macular degeneration / Retinal pigment epithelial transplantation / 網膜移植 / 網膜細胞移植 / 自家周辺部移植
Research Abstract

1) The retinal pigment epithelium cells together with the choroid were obtained from eyeballs through the scleral opening successfully accompanied with minor bleedings. Subsequent retinal detachment was not observed by the fundoscopic examination.
2) Resected specimens were enzymaticaly treated with collagenase in order to isolate the pigment epithelial cells. Marked intra- and inter-experimental differences were observed in isolating the cells, and the repeatable method for isolation has not been established yet.
3) The retinal pigment epithelial cells derived from peripheral areas were transplanted in the subretinal space in normal rabbits in cell suspension or in a form of a single sheet transvitreally. No serious complication such as immune rejection was observed postoperatively, confirming the safety of the transplantation surgery.
4) The TGF-beta neutralizing antibody successfully suppresses the development of experimental proliferative vitreoretinopathy in rabbit eyes.
5) Electroretinograms were examined in patients with various retinal diseases to study retinal function, in order to compare with those in experimental animals.
6) An LED built-in electrode was developed and tested in human eyes.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 山本修一: "網膜色素上皮移植の臨床"日本の眼科. 71. 25-28 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mitamura Y: "Macrophage migration inhibitory factor level in the vitreous"American Journal of Ophthalmology. 129. 678-680 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto T: "Expression and possible role of Activin A in proliferative vitreoretinal diseases"Japanese Journal of Ophthalmology. 44. 221-226 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto S: "Cone electroretinogram amplitude growth with light adaptation in patients with retinitis pigmentosa"Acta Ophthalmologica Scandinavica. 78. 403-406 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mitamura Y: "Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative vitreoretinopathy"American Journal of Ophthalmology. 128. 793-765 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto S: "Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms"Graefe's Archive for Clinical and Experimental Ophthalmology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto S: "Clinical aspects for retinal pigment epithelial transplantation"Journal of Japan Ophthalmologist Association. 71. 25-28 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mitamura Y: "Macrophage migration inhibitory factor level in the vitreous"American Journal of Ophthalmology. 129. 678-680 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto T: "Expression and possible role of Activin A in proliferative vitreoretinal diseases"Japanese Journal of Ophthalmology. 44. 221-226 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto S: "Cone electroretinogram amplitude growth with light adaptation in patients with retinitis pigmentosa."Acta Ophthalmologica Scandinavia. 78. 403-406 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mitamura Y: "Macrophage migration inhibitory factpr levels in the vitreous of patients with proliferative vitreoretinopathy"American Journal of Ophthalmology. 128. 763-765 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto S: "Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms"Graefe's Archive for Clinical and Experimental Ophthalmology. in print.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 山本修一: "網膜色素上皮移植の臨床"日本の眼科. 71. 25-28 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mitamura Y: "Macrophage migration inhibitory factor level in the vitreous"American Journal of Ophthalmology. 129. 678-680 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto T: "Expression and possible role of Activin A in proliferative vitreoretinal diseases"Japanese Journal of Ophthalmology. 44. 221-226 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto S: "Cone electroretinogram amplitude growth with light adaptation in patients with retinitis pigmentosa"Acta Ophthalmologica Scandinavica. 78. 403-406 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto S,et al: "Electroretinogram and visual evoked potentials eliuted by spectral stimuli in a patient with enhanced S-coue syndreme"Jpn J Ophthalmol. 43. 433-437 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mitamura Y,et al.: "Corneal eudothelial loss in eyes undergoing lensectomy"Retina. 20. 59-62 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto S,et al.: "Cone electroretinogoam amplitude growth with light adaptation in patients with retinctis pigmentosa"Acta Ophthalmol scand. 78. in press (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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