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The role of growth factors on wound healing of maxillofacial bone

Research Project

Project/Area Number 10470372
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TAKATO Tsuyoshi  Faculty of Medicine, The University of Tokyo, Professor, 医学部・附属病院, 教授 (90171454)

Co-Investigator(Kenkyū-buntansha) HIKIJI Hisako  Faculty of Medicine, The University of Tokyo, Lecturer, 保健管理センター, 講師 (50292876)
SUSAMI Takafumi  Faculty of Medicine, The University of Tokyo, Associate Professor, 医学部・附属病院, 助教授 (80179184)
HARII Noriyuki  Faculty of Medicine, The University of Tokyo, Professor, 医学部・附属病院, 教授 (50111539)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 1999: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1998: ¥8,300,000 (Direct Cost: ¥8,300,000)
KeywordsMaxillofacial bone / growth factor / wound healing of bone / 顎顔面 / 下顎骨 / 仮骨延長 / 骨治癒 / 顎整形力
Research Abstract

Molecular basis of wound healing of bone affected by mechanical stress has not been studied well. Locally produced autocrine or paracrine factors regulate the wound healing process. Basic fibroblast growth factor (bFGF) has the potent effects on this process. We have shown here the new findings of bFGF.
Fibroblast growth factor-2 (FGF-2) is known to stimulate bone formation and resorption indirectly. We investigated the direct action of on mature osteoclasts. FGF-2 (10-11M) exhibited maximum stimulation (1.9-fold) of pit formation in isolated rabbit osteoclast cultures, whereas in mixed cultures of bone cells, FGF-2 (10-9M) showed the 7.5-fold stimulation. FGF-2 up-regulated the phosphorylation of cellular proteins including p42/p44 mitogen-activated protein (MAP) kinase, and increased the kinase-activity of FGF receptor-1. These results suggest that FGF-2 acts directly on mature osteoclasts through activation of FGF receptor-1 and p42/p44 MAP kinase, causing the stimulation of bone resorption at physiological or pathological concentrations.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Susami T.: "Ellis-van Creveld Syndrome; Craniofacial Morphology and Multidisciplinary Treatment"Cleft Palate-Craniofacial J.. 36. 345-352 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Susami T.: "Multi-Bracket Appliance in Management of Mandibular Reconstruction with Vascularized Bone Graft"Jpn J Clin Oncol. 29. 119-126 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Susami T.: "Stability after distraction osteogenesis in the mandible follow-up with special attention to the occlusal changes"2nd International Congress On Cranial and Facial Bone Distraction Processes. 1999 June. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松本重之: "骨粗鬆症患者の顎骨組織変化に関する実験的研究"Osteoporpsis Japan. vol.7 no.4. 501-503 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小宮徳春: "下顎骨仮骨延長症例の中期変化-延長後5年以上経過して-"日顎変形誌. 9. 12-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸 毅: "顎顔面領域における骨延長法の種々の可能性"形成外科. 第42巻. 1133-1144 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸 毅: "顎顔面領域における骨延長術の応用"Hosp.Dent.. 10. 2-17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松本重之: "腫瘍切除後の再建下顎における機能回復-骨延長およびインプラント植立による咀嚼機能回復-"形成外科. 42. 211-220 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takato T.: "Secondary lengthening of the reconstructed mandible using a gradual distraction technique - two case reports"British Journal of Plastic Surgery. 51(5). 356-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takato T.: "Time-related changes in a case of torus palatinus"Journal of Oral & Maxillofacial Surgery. 56(4). 492-4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸 毅: "骨トランスポート法による顎関節形成術に関する実験的研究-第1報:形態学的検討-"日形会誌. 18,2. 74-82 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸 毅: "骨トランスポート法による顎関節形成術に関する実験的研究-第2報:組織学的検討-"日形会誌. 18,2. 83-91 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸 毅: "Vascularized bone graft"形成外科. 第42巻. 277-285 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高戸毅: "顎骨延長術の臨床応用"クインテッセンス出版株式会社. 206 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Susami T. Kuroda T. Yoshimasu H. Suzuki R.: "Ellis-van Creveld Syndrome ; Craniofacial Morphology and Multidisciplinary Treatment."Cleft Palate-Craniofacial J. 36. 345-352 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takushima A. Susami T. Nakatsuka T. Harii K. Takato T.: "Multi-Bracket Appliance in Management of Mandibular Reconstruction with Vascularized Bone Graft."Jpn J Clin Oncol. 29. 119-126 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Susami T. Takato T. Komiya T. Mori Y. Eguchi T. Matsumoto S.: "Stability after distraction osteogenesis in the mandible : follow-up with special attention to the occlusal changes."2ィイD1ndィエD1 International Congress On Cranial and Facial Bone Distraction Processes. 97-100 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumoto S. Hikiji H. Susami T. Takato T.: "Experimental Study on Changes of Maxillary Tissue in Osteoporosis"Osteoporosis Japan. vol. 7 no. 4. 501-503 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Komiya T. Susami T. Sugibayashi N. Tengan T. Mori Y. Yonehara Y. Tomizuka K. Matsumoto s. Takato T.: "Five-year Follow-up after Mandibular Distraction Lengthening"Jpn. J. Jaw Deform.. 9. 12-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonehara Y. Takato T. Susami T. Matsumoto S. Takato T. Eguchi- T.: "Applications of Bone Lengthening Technique in the Maxillofacial Region"The Japanese Journal of Plastic and Reconstructive Surgery. Vol. 42, No. 12. 1133-1144 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takato T. Mori Y. Eguchi T. Matsumoto S.: "Applications of Bone Distraction Technique in the Maxillofacial Region"Hosp. Dent.. 10. 2-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonehara Y. Matsumoto S. Takato T. Harii K. Nakatsuka T.: "Functional Recovery of Reconstructed Mandibule using Gradual Distraction Technique and Dental Implantation"The Japanese Journal of plastic and Reconstructive Surgery. Vol. 42, No. 3. 211-220 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonehara Y. Takato T. Harii K. Hirabayashi S. Susami T. Komori T. Matsumoto S. Hikiji H. Nakatsuka T.: "Secondary lengthening of the reconstructed mandible using a gradual distraction technique--two case reports"British Journal of Plastic Surgery. 51(5). 356-358 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Komori T. Takato T.: "Time-related changes in a case of torus palatinus."Journal of Oral & Maxillofacial surgery. 56(4). 492-494 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueda S. Takato T. Yonehara Y. Ibata H. Harii K.: "Experimental study of Arthroplasty in the Temporomandibular Joint Using a Bone Transportt Technique -Part I : Morphological Analysis-"J. Jpn. P. R. S.. 18. 74-82 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueda S. Takato T. Yonehara Y. Ibata H. Harii K.: "Experimental Study of Arthroplasty in the Temporomandibular Joint Using a Bone Transport Technique -Part II : Histological Analysis-"J. Jpn. P. R. S.. 18. 83-91 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakatsuka T. Yonehara Y. Ichioka S. Harii K. Takato T. Susami T.: "Vascularized bone graft"The Japanese Journal of Plastic and Reconstructive Surgery. Vol. 42, No. 4. 277-285 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takato T.: "Clinical Applications of Maxilla and Mandibular Distraction Lengthening Technique"206 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Susami T: "Ellis-van Creveld Syndrome ; Craniofacial Morphology and Multidisciplinary Treatment"Cleft Palate-Craniofacial J. 36. 345-352 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Susami T: "Multi-Bracket Appliance in Management of Madibular Reconstruction with Vascularized Bone Graft"Jpn J Clin Oncol. 29. 119-126 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Susami T: "Stability after distraction osteogenesis in the mandible follow-up with special attentic to the occlusal changes"2^<nd> International Congress On Cranial and Facial Bone Distraction Processes. 1999 june. 97-100 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本重之: "骨粗鬆症患者の顎骨組織変化に関する実験的研究"Osteoporpsis Japan. vol.7 no.4. 501-503 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小宮徳春: "下顎骨仮骨延長症例の中期変化-延長後5年以上経過して-"日顎変性誌. 9. 12-22 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "顎顔面領域における骨延長法の種々の可能性"形成外科. 第42巻. 1133-1144 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "顎顔面領域における骨延長術の応用"Hosp.Dent. 10. 2-17 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本重之: "腫瘍切除後の再建下顎における機能回復-骨延長およびインプラント植立による咀嚼機能回復-"形成外科. 42. 211-220 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takato T: "Secondary lengthening of reconstructed mandible using a gradual distraction techique-two case reports"British Jounal of Plastic Surgery. 51(5). 356-358 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takato T: "Time-related changes in a case torus palatinus"Jounal of Oral & Maxillofacial Surgery. 56(4). 492-494 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "骨トランスポート法による顎関節形成術に関する実験的研究-第1報 : 形態学的検討"日形会誌. 18,2. 74-82 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "骨トランスポート法による顎関節形成術に関する実験的研究-第2報 : 形態学的検討"日形会誌. 18,2. 83-91 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "Vascularized bone Graft"形成外科. 第42巻. 277-285 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高戸 毅: "顎骨延長術の臨床応用"クインテッセンス出版株式会社. 206 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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