| Project/Area Number |
10470377
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | KANSAI MEDICAL UNIVERSITY |
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Principal Investigator |
OGAWA Yutaka KANSAI MEDICAL UNIVERSITY, MEDICINE, PROFESSOR, 医学部, 教授 (70026912)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Hideaki KANSAI MEDICAL UNIVERSITY, MEDICINE, ASSISTANT, 医学部, 助手 (10227689)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 2000: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | KELOID / IMMUNUSUPPRESSER / LICHEN PILARIS / FIBROBLAST / APOTOSIS / ANTIBIOTICS / TNF α / IL6 / 毛嚢培養 / 抗生剤 / 増殖抑制 |
|---|
| Research Abstract |
Keloid revealed to be combined with lichen pilaris in high frequency. 62.8% of keloid patients had lichen pilaris on their arms. The other hand only 1.1% of non-keloid control showed combination of lichen pilaris. The high rate of the coexistence suggests that the hair-related disorder may be related to the etiological factor of keloid formation. The growth of human fibroblast was inhibited with various kinds of antibiotics and immunodepressant agents.
The high depression group included Cefazolin, Cefalotin, Cefotiam, Flomoxef et al, the moderate depression group were piperacillin, Gentamycin and the low depression group were Vancomycin, Teichoplanin, Minomycine et.
Apotosis was found more on the active part of the keloid tissue than the inactive part.
IL6 was found to be promoting for the hair growth in rat experiment.
Topical injection of IL6 proved the fact.
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