| Project/Area Number |
10470411
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
OHATA Noboru Hokkaido Univ.School of Dent., Pro., 歯学部, 教授 (60002185)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Noriyuki School of Dent., Inst., 歯学部, 助手 (00271669)
WATARI Humio Hokkaido Univ.School of Dent., Pro., 歯学部, 教授 (70158682)
KUBOKI Yoshinori Hokkaido Univ.School of Dent., Pro, 歯学部, 教授 (00014001)
UO Motohiro School of Dent., Inst., 歯学部, 助手 (20242042)
UEDA Yasuo School of Dent., Lec., 歯学部, 講師 (30241342)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 1999: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | Artificial Periodontal Ligament / Bio-mechanics / Tooth Replantation / Fibrous Collaguen Membrane / Dental Implant |
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| Research Abstract |
(1)Development Hybrid Type of Periodontal Ligament
The purpose of this study is to confirm the regeneration in the replanted tooth of Beagle dog by rhBMP-2 combined with ribbon (3 mm width) of fibrous collagen membrane (FCM). Twenty-four premolars of three beagle dogs were carefully extracted after thier root canals were treated. Before replantation their periodontal ligament and cementum were partially removed in a belt-type area (3 mm width) around the middle part of the root, and the denuded areas of root dentin were covered with FCM/rhBMP-2. It was concluded that combination of rhBMP-2 and FCM incduces periodontal ligament and cementum in the replanted tooth.
(2)Diagnostic Imaging by Radiographs for Periodontal Membrane of Replanted and Transplanted tooth in Human
We concluded that the normal space of periodontal membrane comfirmed 2-weeks fter the replantation and 4-weeks after the transplantation.
(3)Periodontal regeneration in replanted tooth in rabit.
We comfirmed the regeneration of priodontalligament 4-weeks after replantation was equivalent to the control tooth.
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