| Project/Area Number |
10470429
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamanashi Medical University |
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Principal Investigator |
OHMSI Masatoshi Yamanashi Medical University, Oral and Maxillofacial Surgery Professor, 医学部, 教授 (50014139)
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Daisaku Yamanashi Medical University, Oral and Maxillofacial Surgery Ressearch Associate, 医学部, 助手 (50313797)
OHTSUKI Kayoko Yamanashi Medical University, Oral and Maxillofacial Surgery Associate Professor, 医学部, 助教授 (20185325)
平井 豊 山梨医科大学, 医学部, 助手 (40267539)
福田 敏博 山梨医科大学, 医学部, 助手 (50283213)
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| Project Period (FY) |
1998 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Bone Formation / Biocompatibilityr / Osteo induction / Costeo conduction / Compression ostheosynthesis / BMP / Mandibular reconstruction / Pnrnufi / 人工骨 / アパタイトセラミックス / 骨内補填 / 圧迫骨接合 / 固定性 / 顎骨欠損 / 補填 / 骨形成 / 再建手術 / アパタイト多孔体 / セラミックス / バイオマテリアル / アパタイト / 人工骨補填材 / 添加補填 / 架橋補填 / 充填 / 骨癒合 / 複合体 |
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| Research Abstract |
Porous block hydroxy apatite.an artificial bone implant,was evalvated as a bone graft scbstitute based on the results of Long-term evaluation in a total of 41 patients who underwent reconstruction of the jaw bone,especially the mandibles.and the circum ferential tissues.
According to the results of observations and examinations, the condition of bone formation in the porous block hydroxyapatite differed according to the formot remaining bones after the resection of the mandible. And the degree of bone formation was noted to decrease in the following order :
(1) Interlocking filling for partial defects (2) Filling following marginal resection with mandibular margins remaining(3) Additional fillingon the bone surface(4) Filling followingsegmental(5) Filling following semi-mandibular resection
New bone formation was confirmed in the most areas in categories (1) and (2) above, and a complex biocomposite composed of embedded artificialbone and living bone tissues was observed.Approximately 50% biocomposits formation was confirmed in the cases in category (3). In the cases in category (4) and (5), biocomposite formation was only observed in the stumpu that were in contact with the surface of the bone.
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