| Project/Area Number |
10470517
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOSHIMURA Manabu Kyoto Prefectural University of Medicine, Faculty of medicine, Professor, 教授 (40094453)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Masato Kyoto Prefectural University of Medicine, Faculty of medicine, Assistant Professor, 講師 (50218202)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 1999: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | HGF / Neovascularization / Arteriosclerosis / Atherosclerosis / Diabetic retinopathy / Proliferative retinopathy / Purpura / Marker of lesion / 動脈硬化症 / 細動脈硬化症 / coronary atherosclerosis / PTCA / restenosis / monocyte / mRNA |
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| Research Abstract |
To investigate the role of human hepatocyte growth factor (hHGF) in vascular lesions associated with endothelial injury, we measured serum hHGF concentrations in subjects with retinal arteriosclerosis, coronary atherosclerosis, or arteriolitis due to Henoch-Schonlein purpura. Individuals with more advanced grades of retinal arteriosclerosis showed higher serum hHGF concentrations [grade 0, 0.053【minus-plus】0.005 ng/ml (n=68) ; grade 1, 0.144【minus-plus】0.022 ng/ml ( n=21 ; P<0.01vs. Grade 0) ; grade 2, 0.338【minus-plus】0.036 ng/ml ( n=20 ; P<0.01vs. Grade 0 or 1) ; grade 3, 0.526【minus-plus】0.051 ng/ml ( n=9 ; P<0.01vs.grade 0, 1, or 2)]. Patients with active arteriolitis due to Henoch-Schonlein purpura showed higher ( P<0.01) serum hHGF concentrations (0.347【minus-plus】0.038 ng/ml ; n=14) than those in the remission phase (0.097【minus-plus】0.017 ng/ml ; n=19). Mean serum hHGF concentrations were higher in subjects with coronary atherosclerosis than in those without, but a significant overlap in serum hHGF concentrations was found between subjects with and those without coronary atherosclerosis. Serum hHGF may be an indicator of the presence or development of arteriolar lesions.
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