| Project/Area Number |
10480205
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Aichi Cancer Center |
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Principal Investigator |
INAGAKI Masaki Division of Biochemistry Chief, Aichi Cancer Center, 発がん制御研究部, 部長 (30183007)
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| Co-Investigator(Kenkyū-buntansha) |
INADA Hiroyasu Division of Biochemistry Section Researcher, Aichi Cancer Center, 発がん制御研究部, 研究員 (90283522)
NAGATA Koichi Division of Biochemistry Section Head, Aichi Cancer Center, 発がん制御研究部, 室長 (50252143)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | Phosphorylation / Cleavage furrow / Phosphopeptide antibodies / Rho / Cytokinesis / Intermediate filament (IF) / Rho-associated kinase (Rho-kinase) / Rho-キナーゼ / ケラチン結合蛋白質 / 中間径フィラメント構築制御 / 細胞周期 / 中間径フィラメント(1F)蛋白質 / リン酸化反応 / リン酸化ペプチド抗体 / Rho |
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| Research Abstract |
Intermediate filaments (IFs), which form the structural framework of cytoskeleton, have been found to be dramatically reorganized during mitosis. Some protein kinases activated in mitosis are thought to control spatial and temporal IF reorganization through phosphorylation of IF proteins. Rho-associated kinase (Rho-kinase), one of. the putative targets of the small GTPase Rho, does phosphorylate IF proteins, specifically at the cleavage furrow during cytokinesis. This cleavage furrow-specific phosphorylation plays an important role in the local IF breakdown and efficient separation of IF networks, Recent studies on Rho signaling pathways have allowed new models about the molecular mechanism of rearrangements of cytoskeletons including IFs during cytokinesis.
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