The common mechanisms for the determination of organ identity
Project/Area Number |
10480207
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | TOHOKU UNIVERSITY |
Principal Investigator |
KURATA Shoichiro Graduate School of Pharmaceutical Sciences, Tohoku Univ., Associate Professor, 大学院・薬学研究科, 助教授 (90221944)
|
Project Period (FY) |
1998 – 1999
|
Project Status |
Completed (Fiscal Year 1999)
|
Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1999: ¥4,000,000 (Direct Cost: ¥4,000,000)
|
Keywords | Organogenesis / Notch signaling / Master control genes / ホメオティック遺伝子 / 遺伝子発現制御 / ショウジョウバエ / アフリカツメガエル / アニマルキャップ / Pax6 |
Research Abstract |
The Notch signaling pathway defines an evolutionarily conserved cell-cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals. Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-less, which in combination with homeotic genes induce the formation of eyes, wings, antennae, and legs. Therefore, Notch is involved in a common regulatory pathway for the determination of the various Drosophila appendages.
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Report
(3 results)
Research Products
(12 results)