• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

High-resolution imaging and tissue characterization using a miniaturized ultrasound probe mounted on a puncturing needle

Research Project

Project/Area Number 10480239
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KUDO Nobuki  Hokkaido Univ., Grad.School of Eng., Inst., 大学院・工学研究科, 助手 (30271638)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Tadashi  Hokkaido Univ., Grad.School of Med., Inst., 大学院・医学研究科, 助手 (80281814)
MIKAMI Taisei  Hokkaido Univ., College of Med.Tech., Asso.Prof., 医療技術短期大学部, 助教授 (90250456)
YAMAMOTO Katsuyuki  Hokkaido Univ., Grad.School of Eng., Prof., 大学院・工学研究科, 教授 (10088867)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywordsultrasound / wide band / tissue characterization / attenuation / tissue blood flow / correlation technique / 組織性状計測 / 超音波減衰計測 / 組織血流計測
Research Abstract

In this study, a high-frequency miniaturized ultrasound probe mounted on a puncturing needle and an imaging system for this probe have been developed. The usefulness of this imaging system has been evaluated in in vitro and in vivo experiments. We have also studied the feasibility of tissue characterization using ultrasound attenuation in a high-frequency region. The following results were obtained.
Development of the miniaturized ultrasound probe and imaging system A miniaturized probe mounted on a 16-20 gage puncturing needle that can be stuck into a tissue has been developed. A 2-D ultrasound image was obtained by the developed imaging system within about 6 seconds. Practical usefulness of this system was examined by phantom and animal experiments.
Detection of blood flow in a small vessel using a correlation technique The imaging system was applied to the detection of blood flow using a correlation technique in a small vessel at deep portion of a body. To evaluate this flow detection method, we carried out in vitro and in vivo experiments and confirmed that flow in a tube of 0.35 mm in inner diameter can be detected.
Attenuation measurement in 5-40 MHz and study on mechanisms of attenuation in biological tissue To show a feasibility to characterize a biological tissue from its frequency dependence of ultrasound attenuation, we developed a wide-band attenuation measurement system. From the results of measurements, it was concluded that ultrasound attenuation in a biological tissue is mainly due to tissue-organizing substances, such as protein and water, and the macroscopic structure of a tissue such as muscle fibers and that the cell structure of the tissue little contribute the attenuation.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (60 results)

All Other

All Publications (60 results)

  • [Publications] 工藤信樹: "超音波RFエコー解析による頸動脈壁厚計測に関する検討"超音波医学. 25. 155-166 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 張旭: "相関法を用いた単一集束超音波ビームによる変位・流速ベクトルの計測特性の理論解析"超音波医学. 25. 167-178 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Ultrasound attenuation measurement of tissue in frequency range 2.5-40 MHz using a multi-resonance transducer"1998 IEEE UFFC Ultrasound Symposium Proceedings. 1479-1482 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Michiya NATORI: "Threshold of microbubble agents collapse by ultrasound Irradiation"1998 IEEE UFFC Ultrasound Symposium Proceedings. 1435-1438 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masashi WATANABE: "Chronic Effects of Enalapril and Amlodipine on Cardiac Remodeling in Cardiomyopathic Hamster Hearts"Journal of Cardiovascular Pharmacology. 32. 248-259 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 吉田誠: "生体組織の超音波減衰に関する基礎的検討 -組織構造の減衰特性への影響-"電子情報通信学会技術研究報告. 98. 75-80 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaori KURIBAYASHI: "A High-magnification and high-speed system for the observation of microbubbles under ultrasound exposure"1999 IEEE Ultrasonics Symposium Proceedings. 1755-1758 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ken-ichiro NAKAJIMA: "A study on frequency dependence of ultrasound attenuation of biological tissue in the frequency range of 2-40 MHz"1999 IEEE Ultrasonics Symposium Proceedings. 1381-1384 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hideki KUMAMOTO: "Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154"American Journal of Physiology. 276. H1117-1123 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 池田剛史: "穿刺型超音波マイクロプローブに関する基礎的研究 -相関法を用いた微小血管血流の計測-"日本超音波医学会基礎技術研究会資料. 99. 31-35 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 工藤信樹: "超音波変調光による生体の光イメージングに関する基礎的検討"日本超音波医学会基礎技術研究会資料. 99. 36-41 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 工藤信樹: "超音波照射下における水中微小気泡の高速度・高倍率撮影系に関する検討"日本超音波医学会基礎技術研究部会資料. 99. 3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Observation of dynamic behaviour of microbubbles exposed to ultrasound"Proceedings of 2nd International Kyoto Symposium on Ultrasound Contrast Imaging . 41-42 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaori KURIBAYASHI: "Observation of the behavior of microbubble exposed to ultrasound using a high-speed camera"Proceedings of the 5th Heart Centre European Symposium on Ultrasound Contrast Imaging. 29-32 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Keiko NISHIHARA: "Usefulness of early diastolic flow propagation velocity measured by color Mmode Doppler technique for the assessment of left ventricular diastolic function in patients with hypertrophic cardiomyopathy"Journal of American Society of Echocardiography. 13. 801-808 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中島憲一郎: "生体組織の超音波減衰に関する基礎的検討-生体組織の構造とタンパク質成分の影響-"日本超音波医学会基礎技術研究会資料. 100(1). 7-12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 工藤信樹: "超音波照射下における水中微小気泡のふるまいの観察"日本超音波医学会基礎技術研究部会資料. 100(2). 11-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中村和明: "超音波変調光による生体の光イメージングに関する基礎的検討"2000年度第1回生体情報の可視化技術研究会資料. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中村和明: "超音波変調光による生体の光イメージングに関する基礎的検討(III)-後方散乱光の応用と変調光検出感度の向上-"日本超音波医学会基礎技術研究会資料. 100(4). 26-29 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中村和明: "音響光学効果を用いた生体の光イメージングに関する基礎的検討"北海道工業大学研究紀要. 29(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 工藤信樹(分担執筆): "新超音波医学 第1巻「超音波の基礎」"医学書院. 246 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 工藤信樹(分担執筆): "造影超音波ガイドブック「気泡の物理学」"金原出版(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Measurement of the wall thickness of the carotid artery using ultrasound radiofrequency echo signal"J Med Ultrasonics. 25. 155-166 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Xu ZHANG: "Theoretical analysis of measurement of displacement and velocity vectors with a single focused ultrasound beam using time-domain correlation techniques"J Med Ultrasonics. 25. 167-178 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Ultrasound attenuation measurement of tissue in frequency range 2.5-40 MHz using a multi-resonance transducer"1998 IEEE UFFC Ultrasound Symposium Proceedings. 1479-1482 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Michiya NATORI: "Threshold of microbubble agents collapse by ultrasound Irradiation"1998 IEEE UFFC Ultrasound Symposium Proceedings. 1435-1438 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Masashi WATANABE: "Chronic Effects of Enalapril and Amlodipine on Cardiac Remodeling in Cardiomyopathic Hamster Hearts"Journal of Cardiovascular Pharmacology. 32. 248-259 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaori KURIBAYASHI: "A High-magnification and high-speed system for the observation of microbubbles under ultrasound exposure"1999 IEEE Ultrasonics Symposium Proceedings. 1755-1758 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ken-ichiro NAKAJIMA: "A study on frequency dependence of ultrasound attenuation of biological tissue in the frequency range of 2-40 MHz"1999 IEEE Ultrasonics Symposium Proceedings. 1381-1384 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hideki KUMAMOTO: "Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154"American Journal of Physiology. 276. H1117-1123 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Keiko NISHIHARA: "Usefulness of early diastolic flow propagation velocity measured by color M-mode Doppler technique for the assessment of left ventricular diastolic function in patients with hypertrophic cardiomyopathy"Journal of American Society of Echocardiography. 13. 801-808 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Makoto YOSHIDA: "Basic Study on Ultrasonic Attenuation of Biological Tissue -Effects of Tissue Structure on Ultrasonic Attenuation-"Technical report of IEICE. 98 (135). 75-80 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takefumi IKEDA: "A Study on a Miniaturized Probe Mounted on a Puncturing Needle -Measurement of Flow in a Small Vessel Using a Correlation Technique-"Report of basic technology committee of JSUM. 99 (1). 31-35 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Basic Studies on Optical Imaging of Biological Tissue Using Ultrasound-modulated Light"Report of basic technology committee of JSUM. 99 (1). 36-41 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "A high-magnification and high-speed observation system for the behavior of microbubbles under ultrasound exposure"Rep0rt of basic tecbpology committee of JSUM. 99 (2). 3 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaori KURIBAYASHI: "Observation of the behavior of microbubble exposed to ultrasound using a high-speed camera"Proceedings of the 5th Heart Center European Symposium on Ultrasound Contrast Imaging. 29-32 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Observation of dynamic behaviors of microbubbles exposed to ultrasound"Report of basic technology committee of JSUM. 100 (1). 11-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazuaki NAKAMURA: "Basic study on optical imaging of biological tissue using ultrasound-modulated Light (III)-Use of back-scattered light and improvement of sensitivity-"Report of basic technology committee of JSUM. 100 (4). 26-29 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Observation of dynamic behavior of microbubbles exposed to ultrasound"Proceedings of 2nd International Kyoto Symposium on Ultrasound Contrast Imaging, Kyoto. 41-42 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kazuaki NAKAMURA: "Basic Studies on Optical Imaging of Biological Tissue Using Acousto-optic Effect"Memoirs of the Hokkaido Institute of Technology. 29 (in print). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nobuki KUDO: "Observation of dynamic behaviour of microbubbles exposed to ultrasound"Proceedings of 2nd International Kyoto Symposium on Ultrasound Contrast Imaging. 41-42 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kaori KURIBAYASHI: "Observation of the behavior of microbubble exposed to ultrasound using a high-speed camera"Proceedings of the 5th Heart Centre European Symposium on Ultrasound Contrast Imaging. 29-32 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Keiko NISHIHARA: "Usefulness of early diastolic flow propagation velocity measured by color Mmode Doppler technique for the assessment of left ventricular diastolic function in patients with hypertrophic cardiomyopathy"Journal of American Society of Echocardiography. 13. 801-808 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中島憲一郎: "生体組織の超音波減衰に関する基礎的検討-生体組織の構造とタンパク質成分の影響-"日本超音波医学会基礎技術研究会資料. 100(1). 7-12 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 工藤信樹: "超音波照射下における水中微小気泡のふるまいの観察"日本超音波医学会基礎技術研究部会資料. 100(2). 11-14 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中村和明: "超音波変調光による生体の光イメージングに関する基礎的検討"2000年度第1回生体情報の可視化技術研究会資料. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中村和明: "超音波変調光による生体の光イメージングに関する基礎的検討(III)-後方散乱光の応用と変調光検出感度の向上-"日本超音波医学会基礎技術研究会資料. 100(4). 26-29 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中村和明: "音響光学効果を用いた生体の光イメージングに関する基礎的検討"北海道工業大学研究紀要. 29(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 工藤信樹(分担執筆): "新超音波医学 第1巻「超音波の基礎」"医学書院. 246 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 工藤信樹(分担執筆): "造影超音波ガイドブック「気泡の物理学」"金原出版(印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 池田 剛史: "穿刺型超音波マイクロプローブに関する基礎的研究 -相関法を用いた微小血管血流の計測-"電気学会研究会資料 医用・生体工学研究会. MBE99-25. 31-36 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 工藤 信樹: "超音波照射下における水中微小気泡の高速度・高倍率撮影系に関する検討"日本超音波医学会 基礎技術研究部会資料. BT-99-11. 3-3 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Kudo: "A basic study on a miniaturized probe mounted on a puncturing needle"Proceedings of the first joint BMES/EMBS conference. 1057-1067 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Nakajima: "A study on frequency dependence of ultrasound attenuation of biological tissue in the frequency range of 2-40 MHz"1999 IEEE Ultrasonics Symposium Proceedings. (in print). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Kuribayashi: "A High-magnification and High-speed System for the Observation of Microbubbles under Ultrasound Exposure"1999 IEEE Ultrasonics Symposium Proceedings. in print (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Kuribayashi: "Observation of the behavior of microbubble exposed to ultrasound using a high-speed camera"The 5th Heart Center European Symposium on Ultrasound Contrast Imaging. 29-32 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 吉田 誠: "生体組織の超音波減衰に関する基礎的検討 -組織構造の減衰特性への影響-" 電子情報通信学会 技術研究報告. 98(135). 75-80 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Kudo: "In vitro Study on arterial lumen detection using a correlation technique in IVUS" Proceedings of IEEE Engineering in Medicine and Biology Society. 20. 830-831 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Kudo: "Basic study on the ultrasound attenuation of fibrous biological tissue in teh frequency range of 10-40 MHz" IEEE UFFC Ultrasound Symposium Proceedings. (in print). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 工藤信樹: "5-40MHz帯における生体組織の超音波減衰に関する基礎的検討" 日本超音波医学会 基礎研究部会. B98-22(印刷中). (1998)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi