| Project/Area Number |
10480247
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Sophia University |
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Principal Investigator |
NAKAYAMA Kiyoshi SOPHIA UNIVERSITY, DEPARTMENT OF ELECTRICAL AND ELECTRONICS ENGINEERING, PROFESSOR, 理工学部, 教授 (00053653)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Mitsuhiro TOKAI UNIVERSITY, DEPARTMENT OF SURGERY, LECTURER, 医学部, 講師 (40119673)
SUZUKI Akifumi SOPHIA UNIVERSITY, DEPARTMENT OF ELECTRICAL AND ELECTRONICS ENGINEERING, RESEARCH ASSOCIATE, 理工学部, 助手 (00221317)
SUMI Chikayoshi SOPHIA UNIVERSITY, DEPARTMENT OF ELECTRICAL AND ELECTRONICS ENGINEERING, LECTURER, 理工学部, 講師 (40306981)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥9,300,000 (Direct Cost: ¥9,300,000)
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| Keywords | ULTRASOUND / SHEAR MODULUS / STRAIN / MEASUREMENT / RECONSTRUCTION / INVERSE PROBLEM / HUMAN IN VIVO BREAST TISSUE / IMAGING / ずり (せん断) 弾性率 / ブタばら肉 |
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| Research Abstract |
An effective shear modulus reconstruction technique was developed which uses ultrasonic strain measurements for diagnosis of superficial tissues, I.e,, our previously developed ultrasonic strain measurement and shear modulus reconstruction methods are combined and enhanced. The technique realizes very low computational load, yet yields fairly high quantitativeness, high stability and spatial resolution, and large dynamic range. The feasibility is demonstrated on in vitro pork ribs and in vivo human breast tissues (fibroadenoma and scirrhous carcinoma). Although the stable shear modulus reconstruction images presented here were obtained in only 5 min using a typical workstation (Compaq XP 1000, 500 MHz), they nevertheless possess high stability and spatial resolution over a large dynamic range. It is therefore expected that this newly developed imaging technique has great potential to be practically used as an effective diagnostic tool for superficial tissues. Presently, a variety of in vivo shear modulus images are being obtained to clarify any limitations for further application as a differentiation technique.
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