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Development of advanced CAD system for mammography and its practical application

Research Project

Project/Area Number 10555136
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Measurement engineering
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

KOBATAKE Hidefumi  Tokyo University of Agriculture and Technology Graduate School of Bio-Applications and Systems Engineering Professor, 大学院・生物システム応用科学研究科, 教授 (80013720)

Co-Investigator(Kenkyū-buntansha) HAGIHARA Yoshihiro  Tokyo University of Agriculture and Technology Graduate School of Bio-Applications and Systems Engineering Research Associate, 大学院・生物システム応用科学研究科, 助手 (80293009)
SHIMIZU Akinobu  Tokyo University of Agriculture and Technology Graduate School of Bio-Applications and Systems Engineering Associate Professor, 大学院・生物システム応用科学研究科, 助教授 (80262880)
NAWANO Shigeru  National Cancer Center Department of Radiology Director, 放射線部, 医長
TAKEO Hideya  Fuji Photofilm Co.Ltd. Miyanodai Research and Development Center Researcher, 宮台技術開発センター, 研究員
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥8,500,000 (Direct Cost: ¥8,500,000)
KeywordsComputer Aided Diagnosis / CAD / Mammography / breast cancer / microcalcifications / tumor / 腫瘤影検出 / 診断支援システム
Research Abstract

The purpose of this research project is to develop an improved CAD system for mammography and to heighten the system performance. The main results are as follows.
[1]System robust to variations of imaging condition
The conventional CAD system has been installed is five medical institutions in Japan and its performance had been tested . Each medical institution has its own imaging conditions and the performance of the conventional system depends on them. We have developed new processing algorithm, which makes the CAD system insensitive to the variation of imaging conditions.
[2]Revised tumor detection method
Adaptive ring filter has been developed, which makes it possible to detect tumors with rough and irregular density distributions. The performance of the adaptive ring filter has been shown to be superior to that of the iris filter.
[3]Detection of tumors close to or attached to thoracic wall
Tumors close to or attached to thoracic wall tend to be missed by the conventional CAD system. The detection algorithm for them has been revised. That is, the candidates in the area near thoracic wall are recognized by the different algorithm developed by this project. The performance of the new system has become higher than that of the conventional system.
[4]Advanced microcalcification detection method
Coarse-calcification causes false microcalcifications. We have developed a new method for coarse-calcification detection, which can help decreasing false microcalcification clusters. Complicated background can cause false microcalcifications. We have also developed an algorithm to exclude them.
These methods described above have been installed in the new CAD system.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Yukiyasu Yoshinaga and Hidefumi Kobatake: "The Line Detection Method with Robustness against Contract and Width Variation Applied in Gradient Vector Field"Systems and Computers in Japan. 31. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 荻原義裕,小畑秀文 縄野繁,武尾英哉: "モルフォロジカルフィルタの改良による乳がん微小石灰化像検出システムの高度化"Medical Imaging Technology. 18. 795-804 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 委鬼軍,荻原義裕,清水昭伸 小畑秀文: "勾配ベクトルの点集中性フィルタの特性解析"電子情報通信学会論文誌. J84-D. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小畑秀文: "マンモグラフィにおけるCADシステムの開発"DIGITAL MEKICINE. 1. 77-79 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H. Kobatake, Wei Jun Y. Yoshinaga Y. Hogihara, A. Shimizu: "Nonlinear Adaptive Couvergence Index Filters and Their applications"ICPR. 3. 526-529 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y. Hagihara, H. Kobatake S. Nawano, H. Takeo: "Accurate Detection of Microcalcifications on Mammograms by Improvenent of Morphological Processing"IWDM. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H. Sakai, A. Shimizu, Y. Hagihara H. Kobatake, S. Nawano, H. Takeo: "Improved Detection Method of Tumor Candidates on Digital Mammograms"IWDM. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kobatake and M.Murakami: "Characteristics Analysis of the Iris Filter"Transaction of the Society of Instrument and Control Engineers. Vol.34, No.4. 326-332 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hashimoto, H.Kobatake, H.Takeo and S.Nawano: "Automated Tumor Detection System for Full-Digital Mammography Using Bilateral Comparison in Feature Space"CAR'98. 207-212 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kobatake, H.takeo and S.Nawano: "Tumor Detection System for Full-Digital Mammography"Digital Mammography. 87-94 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kobatake, H.Takeo and S.Nawano: "Microcalcification Detection System for Full-Digital Mammography"Digital Mammography. 201-204 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Yoshinaga and H.Kobatake: "The Line Detection Method with Robustness against Contrast and Width Variation Applied in Gradient Vector Field, The Transactions of Institute of Electrics"Information and Communication Engineers. Vol.J81-D・II. 2547-2555 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yukiyasu Yoshinaga and Hidefumi Kobatake: "Robust extraction of curvilinear convex regions with weak contrast using a gradient vector distribution model"Int.Symp.on Noise Reduction for Imaging and Communication Systems. 157-162 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nawano, K.Murakami, N.Moriyama, H.Kobatake, H.Takeo and K.Shimura: "Computer-Aided Diagnosis in Full Digital Mammography"Investigative Radiology. Vol.34, No.4. 310-316 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hidefumi Kobatake and Shigeru Hashimoto: "Convergence Index Filter for Vector Fields"IEEE Trans.on Image Processing. Vol.8, No.8. 1029-1038 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Kobatake, M.Murakami, H.Takeo and S.Nawano: "Computerized detection of malignant tumors on digital mammograms"IEEE Trans.on Medical Imaging. Vol.18, No.5. 369-378 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jun Wei, Yoshihiro Hagihara and Hidefumi Kobatake: "Detection of Rounded Opacities on Chest Radiographs Using Convergence Index Filter"Proc.of ICIAP, pp.757-761, Venice. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yukiyasu Yoshinaga, Hidefumi Kobatake and Shigehiro Fukushima: "The detection and Feature Extraction Method of Curvilinear Convex Regions with Weak Contrast Using a Gradient Distribution Method"Proc.ICIP. Paper No.26PP1.7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jun Wei, Yoshihiro Hagihara and Hidefumi Kobatake: "Detection of Cancerous Tumors on Chest X-ray Images Candidate Detection Filter and Its Application"Proc.of ICIP. Paper No.27AP4.2 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hidefumi KOBATAKE, WEI Jun, Yukiyasu Yoshinaga and Yoshihiro HAGIHARA: "Nonlinear Adaptive Filters Based on Gradient Vector Orientation"Proc.Of International Symposium on nonlinear Theory and Its Applications, Hawaii. 553-556 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Murakami, H.Kobatake, H.Takeo and S.Nawano: "Feature Extraction of Malignant Tumors on Mammograms"Medical Imaging Technology. Vol.17, No.6. 681-689 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Hashimoto, H.Kobatake, H.Takeo and S.Nawano: "Reduction of False Positives Using Qualitative Feature Comparison of Bilateral Mammograms"The Transactions of Institute of Electrics, Information and Communication Engineers, D-II. Vol.J83-D-II, No.1. 415-418 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Hagihara and H.Kobatake: "A Histogram-Based Morphological Filter to Suppress Artifacts"The Transactions of Institute of Electrics, Information and Communication Engineers. Vol.J82-D・II, No.1. 101-108 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Hagihara and H.Kobatake: "A Morphological Filter with Region Expansion to Extract Minute Convex Regions and Its Application to Medical Image Processing"The Transactions of Institute of Electrics, Information and Communication Engineers. Vol.J83-D-II, No.1. 109-117 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] J.Wei, Y.Hagihara and H.Kobatake: "Convergence Index Filter for Detection of Lung Nodule Candidates"The Transactions of Institute of Electrics, Information and Communication Engineers, Vol.J83-D・II, No.1. 118-125 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yukiyasu Yoshinaga and Hidefumi Koba Taka: "The Line Detection Method with Robustness against Coutroct and Width Voriation Applied in Gradient Vector Field"Systems and Computors in Japan. 31・3. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 萩原義裕,小畑秀文,縄野繁,武尾英哉: "モルフォロジカルフィルタの改良による乳がん微小石灰像検出システムの高度化"Modical Imaging Technology. 18・6. 795-804 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 魏軍,萩原義裕,清水昭伸,小畑秀文: "勾配ベクトルの点集中性フィルタの特性解析"電子情報通信学会論文誌. J84-D-II. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小畑秀文: "マンモグラフィにおけるCADシステムの開発"DIGITAL MEDICINE. 1・3,4. 77-79 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Kobatake,WeiJun,Y.Yoshinaga,Y.Hagihara,A.Shimigu: "Nonlinear Adaptive Convergence Index Filters and Jheir applications"ICPR. 3. 526-529 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Hagihara,H.KoBatake,S.Nawano,H.Takeo: "Accurate Detection of Microcalcifications on Mammograms by Improvement of Morphological Processing"IWPM. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Sakai,A.Shimigu,Y.Hogihara,H.KobaTake,S.Nawano,H.Takeo: "Improved.Detection.Method of Tumor Candidatesa Digital Mammogrms"IWDM. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Nawano: "Computer-Aided Diagnosis in Full Digital Mammography"Investigative Radiology. 34・4. 310-316 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hidefumi Kobatake: "Convergence Index Filter for Vector Fields"IEEE Trans. on Image Processing. 8・8. 1029-1038 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Kobatake: "Computerized detection of malignant tumors on digital mammograms"IEEE Trans. on Medical Imaging. 18・5. 369-378 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 井関: "再帰的領域探索法による胸部CT画像からの欠巻の3次元構造の抽出"電子情報通信学会論文誌. J82-2・9. 1533-1535 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 村上政行: "乳房X線上の悪性腫瘍瘤影の特徴抽出"Medical Imaging Technology. 17・6. 681-689 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 橋本磁: "左右マンモグラム定性的特徴量の比較に基づく偽陽性陰影の削減"電子情報通信学会論文誌. J-83-D-II・1. 415-418 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 萩原義裕: "ヒストグラムを利用したアーチファクトを生じないモルフォロジフィルタ"電子情報通信学会論文誌. J83-D-II・1. 101-108 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 萩原義裕: "不安定微小:凸領域抽出のための領域拡張を伴うモルフォロジカルフィルタとその医用画像処理への応用"電子情報通信学会論文誌. J83-D-II・1. 109-117 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 魏軍: "肺がん陰影候補抽出のための勾配ベクトル集中性フィルタ"電子情報通信学会論文誌. J83-D-II・1. 118-125 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小畑秀文、村上正行: "アイリスフィルタとその特性解析" 計測自動制御学会論文誌. 34・4. 326-332 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Hashimoto,H.Kobatake,H.Takeo and S.Nawano: "Automated Tumor Detection System for Full-Digital Mammography Using Bilateral Comparison in Feature Space" Proc.of CAR'98. 207-212 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] F.Iseki,H.Kobatake,H.Omatsu and R.Kakinuma: "Extraction of 3D Tree Structure of Blood Vessels in Lung Area from Chest CT Images" Proc.of CAR'98. 45-50 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kitaoka,R.Takaki,K.Itoh,F.Iseki,H.Kobatake,H.Ohmatsu,N.Moriyama and K.Eguchi: "Shape Analysis of Pulmonary Nodules in 3D-CT Images with a New Method of Curvature Estimation" Proc.of CAR'98. 51-56 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kobatake,H.Takeo and S.Nawano: "Tumor Detection Syatem for Full-Digital Mammography,N.Karssemeijer et al.Ed." Digital Mammography. 87-94 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kobatake,H.Takeo and S.Nawano: "Microcalcification Detection System for Full-Digital Mammography,N.Karssemeijer et al.Ed." Digital Mammography. 201-204 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 吉永幸靖、小畑秀文: "濃度勾配ベクトルを用いたコントラストや幅に影響されない線領域の検出法" 電子情報通信学会論文誌. J81-D・II. 2547-2555 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 萩原義裕、小畑秀文、志田寿夫: "CT画像を用いたじん肺粒状影の抽出とじん肺症自動分類の試み" Medical Imaging Technology. 16・5. 578-584 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yukiyasu Yoshinaga and Hidefumi Kobatake: "Robust extraction of curvilinear convex regions with weak contrast using a gradient vector distribution model" Proc.of Int.Symp.on Noise Reduction for Imaging and Communication Systems. 157-162 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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