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Synthesis of apatite-organic polymer hybrid materials by chemical modification

Research Project

Project/Area Number 10555217
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Inorganic materials/Physical properties
Research InstitutionKyoto Institute of Technology (2000)
Kyoto University (1998-1999)

Principal Investigator

MINODA Masahiko  Kyoto Inst.of Technology Faculty of Eng.and Design Assoc.Prof., 工芸学部, 助教授 (30229786)

Co-Investigator(Kenkyū-buntansha) KOKUBO Tadashi  Graduate School of Eng., Kyoto University Dept.of Mater.Chem. Prof., 大学院・工学研究科, 教授 (30027049)
宮路 史明  島根大学, 総合理工学部, 助教授 (80219782)
宮本 武明  京都大学, 化学研究所, 教授 (60027050)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥6,700,000 (Direct Cost: ¥6,700,000)
Keywordsbonelike apatite / biomimetic process / silanol group / carboxyl group / calcium ion / ethylene-vinyl alcohol copolymer / polysaccharide / organic fibrous materials / 擬似体液 / エチレン―ビニルアルコール共重合体 / カルボン酸カルシウム塩 / カルボン酸含有多糖類 / アルギン酸繊維 / カルボキシメチル化セルロース / カルボキシメチル化キチン
Research Abstract

In this research was investigated the synthesis of bonelike apatite-organic polymer hybrid materials via a biomimetic process in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma or a solution (1.5SBF) with ion concentrations 1.5 times those of SBF.Main results include :
1. The surface of ethylene-vinyl alcohol copolymer substrates and knitted fibers were modified with silanol (Si-OH) groups by the reaction with a triethoxysilyl group-containing silane coupling agent and the subsequent hydrolysis and polycondensation of tetraethoxysilane. The silanol-modified specimens were found to form apatite layer on them within a few weeks in 1.5SBF.Moreover, the specimens treated with calcium silicate solution can form apatite within a few days even in SBF, indicating introduction of calcium ions into the surface silicate layer brings about the enhanced apatite-forming ability.
2. It was found that the gels prepared from carboxymethyl (CM) cellulose, CM-chitin and gellan gum, all of which possess carboxylate functions, formed apatite on their surfaces within 3 days in SBF, when they were previously treated with a saturated Ca(OH)_2 solution. Calcium alginate gels and fibers originally having carboxyl groups and calcium ions also formed apatite on them within a week in SBF.These results indicate that the carboxylate groups on the gels are effective for the apatite nucleation and the apatite forming ability of the polymer can be improved by incorporation of the calcium ions.
In conclusion, various types of polymers were found to be promising candidates for obtaining apatite-polymer hybrids with bonelike structure through a combination of simple chemical modifications and biomimetic process.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Q.Zhou: "Synthesis and properties of O-2-[2-(2-methoxyethoxy) ethoxy] acetyl cellulose"J.Polym.Sci.,Part A : Polym.Chem.. 39. 376-382 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Kawashita: "Apatite-forming ability of polymers with carboxy groups in simulated body fluid"Bioceramics. 13. 697-700 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Aaptite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate"Bioceramics. 13. 713-716 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with calcium silicate"Transactions of the 6^<th> World Biomaterials Congress Vol.III, pp.1304, Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.2000. 2000. 1304-1304 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.-M.Kim: "Spontaneous formation of bonelike apatite on carboxymethyl-chitin gel in simulated body fluid"Transactions of the 6^<th> World Biomaterials Congress Vol.III, pp.1313, Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.2000. 2000. 1313-1313 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with silanol groups"J.Biomed.Mater.Res.. 47. 367-373 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Takaragi: "Reaction characteristics of cellulose in the LiCl/1,3-dimethyl-2-imidazolidinone solvent system"Cellulose. 6. 93-102 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kokubo: "Preparation of apatite-polymer composites by a biomimetic process"Proceedings of The 5th Asian Textile Conference. 1999. 943-946 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 箕田雅彦: "セルロース機能材料の新展開"高分子加工. 48. 355-360 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kokubo: "Apatite formation on polyethylene modified with silanols by grafting of vinyltrimethoxysilane and subsequent hydrolysis"Korean Journal of Ceramics. 5. 265-269 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Surface modification of ethylene-vinylalcohol copolymer for inducing its apatite-forming ability"Bioceramics. 11. 687-690 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Q.Zhou: "Synthesis and properties of O-2-[2-(2-methoxyethoxy)-ethoxy]acetyl cellulose"J.Polym.Sci., Part A : Polym.Chem.. 39. 376-382 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Kawashita: "Apatite-forming ability of polymers with carboxy groups in simulated body fluid"Bioceramics. 13. 697-700 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Aaptite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate"Bioceramics. 13. 713-716 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with calcium silicate"Transactions of the 6^<th> World Biomaterials Congress Vol.III,pp.1304, Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.-M.Kim: "Spontaneous formation of bonelike apatite on carboxymethyl-chitin gel in simulated body fluid"Transactions of the 6^<th> World Biomaterials Congress Vol.III,pp.1313, Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with silanol groups"J.Biomed.Mater.Res.. 47. 367-373 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Takaragi: "Reaction characteristics of cellulose in the LiCl/1,3-dimethyl-2-imidazolidinone solvent system"Cellulose. 6. 93-102 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kokubo: "Preparation of apatite-polymer composites by a biomimetic process"Proceedings of The 5th Asian Textile Conference. 943-946 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Minoda: ""Development in functional cellulosics" (in Japanese)"Kobunshi-kako. 48. 355-360 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Kokubo: "Apatite formation on polyethylene modified with silanols by grafting of vinyltrimethoxysilane and subsequent hydrolysis"Korean Journal of Ceramics. 5. 265-269 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] A.Oyane: "Surface modification of ethylene-vinylalcohol copolymer for inducing its apatite-forming ability"Bioceramics. 11. 687-690 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Q.Zhou: "Synthesis and properties of O-2-[2-(2-methoxyethoxy)ethoxy]acetyl cellulose"J.Polym.Sci., Part A : Polym.Chem.. 39. 376-382 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Kawashita: "Apatite-forming ability of polymers with carboxy groups in simulated body fluid"Bioceramics . 13. 697-700 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Oyane : "Aaptite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate"Bioceramics . 13. 713-716 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with calcium silicate "Transactions of the 6^<th> World Biomaterials Congress Vol.III, pp.1304,Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.2000. 2000. 1304-1304 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.-M.Kim: "Spontaneous formation of bonelike apatite on carboxymethyl-chitin gel in simulated body fluid"Transactions of the 6^<th> World Biomaterials Congress Vol.III,pp.1313,Ed.by A.F.von Recum and L.C.Lucas, Society for biomaterials, U.S.A.2000. 2000. 1313-1313 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] A.Oyane: "Apatite formation on ethylene-vinyl alcohol copolymer modified with silanol groups"J. Biomed. Mater. Res.. 47. 367-373 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] A.Takaragi: "Reaction characteristics of cellulose in the LiCl/1,3-dimethyl-2-imidazolidinone solvent system"Cellulose. 6. 93-102 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Kokubo: "Preparation of apatite-polymer composites by a biomimetic process"Proceedings of The 5th/Asian Textile Conference. 1999. 943-946 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 箕田雅彦: "セルロース機能材料の新展開"高分子加工. 48. 355-360 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Kokubo: "Apatite formation on polyethylene modified with silanols by grafting of vinyltrimethoxysilane and subsequent hydrolysis" Korean Journal of Ceramics. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Oyane: "Surface modification of ethylene-vinylalcohol copolymer for inducing its apatite-forming ability" Bioceramics. 11. 687-690 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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