| Project/Area Number |
10555317
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
有機工業化学
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| Research Institution | Kansai University |
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Principal Investigator |
SONODA Noboru Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (20083983)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Yutaka Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (30180665)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 1999: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | Carbon Monoxide / Selenium / Selenium Carbon Monoxide / Indol / Quinazolinone / ニトロ化合物 / ナイトレン |
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| Research Abstract |
We investigated the new generation method of unstable chemical species by the use of the characteristics of carbon monoxide and the utilization of these unstable species in organic synthesis. In the course of this study, we found that nitre or nitrenoid species were generated smoothly by the reduction of aromatic nitro compounds with carbon monoxide in the presence of a catalytic amount of selenium. When 0-nitrostyrenes were treated with carbon monoxide in the presence of a catalytic amount of selenium, deoxyganation of nitro group followed by intramolecular cyclization proceeded efficiently to give the corresponding indols in moderate to good yields. On the reaction of 0-nitrobenzoylamides with carbon monoxide, 4(3H)-quinazolinones were synthesized in moderate to good yields. In addition, we have also developed the rhenium complexes having ligand of carbon monoxide acts as a catalyst on the Friedel-Craft alkylation of arenes with alkyl halides, Aldol type reaction of enol silyl ethers with carbonyl compounds and allylation of carbonyl compounds with allyic stannanes.
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