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Thermosensitive polymers prepared from N-vinylacylamide

Research Project

Project/Area Number 10555326
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 高分子合成
Research InstitutionKagoshima University

Principal Investigator

AKASHI Mitsuru  Kagoshima University, Faculty of Engineering, Professor, 工学部, 教授 (20145460)

Co-Investigator(Kenkyū-buntansha) IZUMIKAWA Hiroshi  Mitsubishi Chemical Corporation, Yokohama Research Center, Research Scientist, 横浜総合研究所・機能科学研究所, 副主任研究員
SERIZAWA Takeshi  Kagoshima University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (30284904)
佐藤 真一  三菱化学株式会社, 研究開発本部・技術開発センター, 主席研究員
岸田 晶夫  国立循環器病センター研究所, 生体工学部, 部長 (60224929)
Project Period (FY) 1998 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywordsthermosensitive polymers / N-vinylacylamides / N -vinylisobutyramide / poly (N-isopropylacrylamide) / polymeric nanosheres / platinum colloids / DDS / LCST behavior / N-ビニルアシルアミド / 下限臨界溶解温度(LCST) / ビニルアミン / 刺激応答性 / 金属保護触媒 / 刺激応答性高分子 / ラジカル重合 / 水溶性高分子 / 金属コロイド / 触媒活性 / 2相分離 / ヒドロゲル / 感熱応答性 / グラフト / 白金コロイド触媒 / 高分子ナノスフェア
Research Abstract

We have developed novel thermosensitive polymers consisting of N-vinylacylamides such as N-vinylisobutyramide (NVIBA) and studied their properties and application comparing with poly (N-isopropylacrylamide) (PNIPAAm). First, we synthesized N-vinylacylamide monomers and polymerized using a free radical polymerization technique. After preparing water soluble polymers and cross-linked hydrogels, their thermosensitive properties were studied in comparison with PNIPAAm. It is A found that LCST of PNVIBA is sharply 39 ℃. Dispersion copolymerization of styrene and PNIPAAm or PNVIBA macromonomers gave water dispersible core-corona type polymeric nanospheres by self-assembling mechanism. Platinum and silver colloids were effectively entrapped on the surfaces (that is corona) of thermosensitive polymeric nanospheres to act as catalyst for hydrogenation in case of platinum colloids. When peptides were physically immobilized in corona of nanospheres, this system seemed to be a well-designed oral peptide drug delivery system from the results of animal examinations. Finally, we clarified that commercially available N-vinylformamide or N-vinylacetoamide were copolymerized with vinylacetate to give thermosensitive polymers as well as PNIPAAm and PNVIBA.

Report

(5 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Kazuya Suzuki: "Thermo-Responsive Release From Interpenetrating Porous Silica-Poly (N-isopropylacrylamide) Hybrid Gels"J. Controlled Release. 75. 183-189 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Yamamoto: "Synthesis and Functionalities of Poly(N-Vinylalkylamide) XIII. Synthesis and Properties of Thermal and pH Stimuli-Responsive Poly (vinylamine) Copolymers"Macromolecules. 34. 8014-8020 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Suzuki: "pH-Responsive Model Drug Release from Silica-Poly(methacrylic acid) Interpenetrating Gel Hybrids"J. Bloactive and Compatible Polym.. 16. 409-418 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Serizawa: "Rapid Deswelling of Porous Poly(N-isopropylacrylamide) Hydrogels Prepared by Incorporation of Silica Particles"Macromolecules. 35. 10-12 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Serizawa: "Thermo-Responsive Ultrathin Hydrogels Prepared by Sequential Chemical Reactions"Macromolecules. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chun-Wei Chen: "In Situ Formation of Au/Pt Bimetallic Colloids on Polystyrene Microspheres : Control of Particle Growth and Morphology"Chem. Mater.. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Suzuki et al.: "Thermo-Responsive Release From Interpenetrating Porous Silica-Poly (N-isopropylacrylamide) Hybrid Gels"J. Controlled Release. Vol.75. 183-189 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Yamamoto et al.: "Synthesis and Functionalities of Poly (N-Vinylalkylamide) XIII. Synthesis and Properties of Thermal and pH Stimuli-Responsive Poly(vinylamine) Copolymers"Macromolecules. Vol.34. 8014-8020 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Suzuki et al.: "pH-Responsive Model Drug Release from Silica-Poly (methacrylic acid) Interpenetrating Gel Hybrids"J. Bioactive and Compatible Polym.. Vol.16. 409-418 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Serizawa et al.: "Rapid Deswelling of Porous Poly (N-isopropylacrylamide) Hydrogels Prepared by Incorporation of Silica Particles"Macromolecules. Vol.35. 10-12 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Serizawa et al.: "Thermo-Responsive Ultrathin Hydrogels Prepared by Sequential Chemical Reactions"Macromolecules. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chun-Wei Chen et al.: "In Situ Formation of Au/Pt Bimetallic Colloids on Polystyrene Microspheres : Control of Particle Growth and Morphology"Chem. Mater.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuya Suzuki: "Thermo-Responsive Release From Interpenetrating Porous Silica-Poly(N-isopropylacrylamide) Hybrid Gels"J.Controlled Release. 75. 183-189 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazuya Yamamoto: "Synthesis and Functionalities of Poly (N-Vinylalkylamide) XIII. Synthesis and Properties of Thermal and pH Stimuli-Responsive Poly (vinylamine) Copolymers"Macromolecules. 34. 8014-8020 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazuya Suzuki: "pH-Responsive Model Drug Release from Silica-Poly (methacrylic acid) Interpenetrating Gel Hybrids"J.Bioactive and Compatible Polym.. 16. 409-418 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshi Serizawa: "Rapid Deswelling of Porous Poly (N-isopropylacrylamide) Hydrogels Prepared by Incorporation of Silica Particles"Macromolecules. 35. 10-12 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshi Serizawa: "Thermo-Responsive Ultrathin Hydrogels Prepared by Sequential Chemical Reactions"Macromolecules. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Chun-Wei Chen: "In Situ Formation of Au/Pt Bimetallic Colloids on Polystyrene Microspheres : Control of Particle Growth and Morphology"Chem.Mater.. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Shigeru Kunugi,Tomoko Tada,Yoshiaki Yamazaki,Kazuya Yamamoto,Mitsuru Akashi: "Thermodynamic Studies on Coil-Globule Transitions of Poly (N-vinylisobutyramide-co-vinylamine) in Aqueous Solutions"Langmuir. 16. 2042-2044 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chun-Wei Chen,Daisuke Tano,Mitsuru Akashi: "Colloidal Platinum Nanoparticles Stabilized by Vinyl Polymers with Amide Side Chains : Dispersion Stability and Catalytic Activity in Aqueous Electrolyte Solutions"J.Colloid and Interface Sci.. 225. 349-358 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chun-Wei Chen,Takashi Takezako,Kazuya Yamamoto,Takeshi Serizawa,Mitsuru Akashi: "Poly (N-vinylisobutyramide)-Stabilized Platinum Nanoparticles : Synthesis and Temperature-Responsive Behavior in Aqueous Solution"Colloids Surf.. 169. 107-116 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kazuya Yamamoto,Takeshi Serizawa,Yoichiro Muraoka,Mitsuru Akashi: "Synthesis and Functionalities of Poly (N-Vinylalkylamide).XII Synthesis and Thermosensitive Property of Poly (vinylamine) Copolymer Prepared from Poly (N-vinylformamide-co-N-vinylisobutyramide)"J.Polym.Sci.Part A : Polym.Chem.. 38. 3674-3681 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chun-Wei Chen,Kumiko Arai,Kazuya Yamamoto,Takeshi Serizawa,Mitsuru Akashi: "Temperature and pH Dependence of Catalytic Activity of Colloidal Platinum Stabilized by Poly (vinylamine-co-N-vinylisobutyramide)"Macromol.Chem.and Phys.. 201. 2811-2819 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mitsuru Akashi,Akio Kishida: "Synthesis of Novel Smart Polymers for Bioseparation and Bioprocessing"New Stimuli Responsive Polymers for Bioseparation and Bioprocessing (B.Mattiasson,I.Galaev eds.)(in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ming-Qing Chen,Takeshi Serizawa,Mitsuru Akashi: "Graft Copolymers Having Hydrophobic Backbone and Hydrophilic Branches.XVII..Effects of Various Parameters on Size and Morphology of Microspheres Using Poly(N-isopropylacrylamide) as a Steric Stabilizer"Polym.Adv.Tech.. 10. 120-126 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chun-Wei Chen,Mitsuru Akashi: "Temperature-Responsive Catalytic Activity of Poly(N-isopropylacylamide)-Protected Au/Pt Bimetallic Nanoparticles in Aqueous Solution"Adv.Tech.. 10. 17-133 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chun-Wei Chen,Takeshi Serizawa,Mitsuru Akashi: "Preparation of Platinum Colloids on Polystyrene Nanospheres and Their Catalytic Properties in Hydrogenation"Chem.Master. 11. 1381-1389 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chun-Wei Chen,Daisuke Tano,Mitsuru Akashi: "Synthesis of Platinum Colloids Sterically Stabilized by Poly(N-vinylformamide) or Poly(N-vinylalkylamide) and Their Stability towards Salt"Colloid Polym.Sci.. 277. 488-493 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeru Kunugi,Kazuya Takano,Naoki Tanaka,Mitsuru Akashi: "Effects of Ionic Additives and Ionic Comonomer on the Temperature and Pressure Responsive Behavior of Thermoresponsive Polymers in Aqueous Solutions"Langmuir. 15. 4056-4061 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akiko Kishida,Yoshihiri Kikunaga,Mitsuru Akashi: "Synthesis and Functionalities of Poly(N-Vinylalkylamide).X.A Novel Aqueous Two-Phase Systems Based on Thermosensitive Polymers and Dextran"J.Appl.Polym.Sci. 73. 2545-2548 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chun-Wei Chen,Takashi Serizawa,Mitsuru Akashi,: "Synthesis and Characterization of Poly(N-isopropylacrylamide)-Coatd Polystyrene Microspheres with Silver Nanoparticles on Their Surfaces"Langmuir. 15. 7998-8006 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chun-Wei Chen,Takashi Takezako,Kazuya Yamamoto,Takeshi Serizawa,Mitsuru Akashi: "Poly(N-vinylisobutyramide)-Stabilized Platinum Nanoparticles: Synthesis and Temperature-Responsive Behavior in Aqueous Solution"Colloids Surf.. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazuya Suzuki,Takashi Yumura,Masaaki Mizuguchi,Yuko Tanaka,Chun-Wei Chen,Mitsuru Akashi: "Poly(N-isopropylacrylamide)-Grafted Silica as a Support of Platinum Colloids: Preparation Method,Characterization,and Catalytic Properties in Hydrogenation"J.Appl.Polym.Sci. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeru Kunugi,Tomoko Tada,Yoshiaki Yamazaki,Kazuya Yamamoto,Mitsuru Akashi: "Thermodynamic Studies on Coil-Globule Transitions of Poly(N-vinylisobutyramide-co-vinylamine)in Aqueous Solutions,"Langmuir. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] 明石 満,山元和哉: ""ポリマーゲル",ラジカル重合ハンドブック(蒲池幹治,遠藤 剛監修)"エヌ・ティー・エス. 8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mitsuru Akashi,Akio Kishida: ""New Stimuli Responsive Polymers for Bioseparation and Bioprocessing",Synthesis of Novel Smart Polymers for Bioseparation and Bioprocessing(B.Mattiasson,I.Galaeveds.,)"Harwood Publisher(印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] F.Seto,K.Fukuyama,Y.Muraoka,A.Kishida,M.Akashi: "Thermosensitive Surface Properties of Polyethylene Film with Poly(N-isopropyl-acrylamide)Chains Prepared by Corona Discharge Induced Grafting" J.Appl.Polym.Sci.68. 1773-1779 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] C.W.Chen,M.Q.Chen,T.Serizawa,M.Akashi: "In Situ Synthesis ans Their Catalytic Properties of Platinum Colloids on Polystyrene Microsphers with Surface-Grafted Poly(N-isopropylacrylamide)." J.Chem.Soc.Chem.Commun.831-832 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Suwa,K.Yamamoto,M.Akashi,K.Takano,N.Tanaka,S.Kunugi: "Effects of Salt on the Temperature and Pressure Responsive Properties of Poly(N-vinylisobutyramide)Aqueous Solution" Colloid Polym.Sci.276. 529-533 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] C.W.Chen,M.Q.Chen,T.Serizawa,M.Akashi: "In Situ Formation of Silver Nanoparticles on Poly(N-isopropylacrylamide)-Coated Polystyrene Microspheres" Adv.Mater.10. 1122-1126 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Q.Chen,T.Serizawa,M.Akashi: "Graft Copolymers Having Hydrophobic Backbone and Hydrophilic Branches.XVII.Effects of Various Parameters on Size and Morphology of Microspheres Using Poly(N-isopropylacrylamide)as a Steric Stabilizer." Polym.Adv.Tech,. 10. 120-126 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] C-W.Chen,M.Akashi: "Temperature-Responsive Catalytic Activity of Poly(N-isopropylacrylamide)-Protected Au/Pt Bimetallic Nanoparticles in Aqueous Solution" Polym.Adv.Tech,. 10. 127-133 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] F.Seto,Y.Muraoka,T.Akagi,A.Kishida,M.Akashi: "Appl.Polym.Sci.," Surface Grafting of Poly(vinylamine)onto Poly(ethylene)Film by Corona Discharge Induced Grafting, (印刷中

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Kunugi,K.Takano,N.Tnanka,M.Akashi: "Langmuir" Effects of Ionic Additives and Ionic Comonomer on the Temperature and Pressure Responsive Behavior of Thermoresponsive Polymers in Aqueous Solutions., (印刷中

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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