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Development of the evaluative method for harmful effects of environmental pollutant on the neurotransmission and genetic transcription.

Research Project

Project/Area Number 10557039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Hygiene
Research InstitutionHokkaido University

Principal Investigator

SAITO Takeshi  Hokkaido Univ., School of Med., Asso. Pro., 医学部, 助教授 (40153811)

Co-Investigator(Kenkyū-buntansha) HATA Akira  Asahikawa Med. College, Pro., 医学部, 教授 (00244541)
HOSOKAWA Toshiyuki  Hokkaido Univ., Center of Res. Develop. Higher Edu., Asso. Pro., 高等教育機能開発総合センター, 助教授 (00157025)
TAKAHASHI Kyoko  Hokkaido Univ., School of Med., Inst., 医学部, 助手 (50292008)
MORIMOTO Kanehisa  Osaka Univ., School of Med., Pro., 医学部, 教授 (20143414)
KURASAKI Masaaki  Hokkaido Univ., Grad. School of Env. Earth Sci., Inst., 大学院・地球環境科学研究科, 助手 (80161727)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 1999: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1998: ¥8,300,000 (Direct Cost: ¥8,300,000)
Keywordsenvironmental pollutant / neurotransmission / genetic transcription / evaluation of dysfunction / central nervous system / gene
Research Abstract

In the present study, we intended to develop the evaluative method for harmful effects of environmental pollutant on the neurotransmission and genetic transcription. Main results obtained in the present investigations are as follows;
1.To elucidate the effects of the endocrine disrupters on bioorganisms, the influence of Tributyltin (TBT) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) on apoptosis and differentiation at low concentrations using PC12 cell were investigated. TBT or 2,4,5-T suppressed the apoptosis and differentiation of the cultured cells. Naturally occurring neuronal death is a well-established phenomenon that occurs during development of the vertebrate nervous system. The results of the study indicated the possibility that the chemical substances such as TBT or 2,4,5-T could prevent cell differentiation and/or development in the mammalian body. Since apoptosis and cell differentiation are essential for normal development and elimination of harmful cells, suppression of apoptosis and differentiation by TBT and 2,4,5-T would be damaging for individuals.
2. The effect of trichloroethylene (TCE) on LTP was studied using both electrical and optical recording. The post per pre ratio of population spikes (PS) was smaller in TCE groups than in the control. The post per pre ratio of the optical signals was smaller in TCE than in the control. It was suggested that the impairment of LTP may be one of the mechanisms of the impairment of the immediate memory after the acute exposure to TCE in human.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Wang YP.et al.: "Alteration in hippocampal and cerebral expression of glial fibrillary acidic protein following styrene exposure in rat"Neuropathology. 18. 289-294 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa T.et al.: "Optical monitoring of living brain tissue"Alcoholism : Clinical And Experimental Research. 22(1). 60-66 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa T.et al.: "Effect of steroid on the confocal imaging of dendritic spines in the living hippocampal slice"Society for Neuroscience Abstracts. 25(1). 1269 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito T.et al.: "Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissues of the rat"Neurosci Lett. 266. 13-16 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurasaki M.et al.: "Histochemical Characterizaion of Silver-Induced Metallothionein in Kidney of Rat"J.Inorg.Biochem. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura N.et al.: "Analysis of activation in anterior cingulate cortex during cognitive process of selection following somatosensory stimuli : fMRI study with elaborate task paradigms"Magnetic Resonance Imaging. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito T.et al.: "Trace Elements in Man and Animal 10"Plenum Publishing Co., New York(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa T.et al.: "Trace Elements in Man and Animal 10"Plenum Publishing Co., New York(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang, Y. et. Al: "Alteration in hippocampal and cerebral expression of glial fibrillary acidic protein following styrene exposure in rat."Neuropathology. 18. 289-294 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa, T. et, al: "Optical monitoring of living brain tissue."Alcoholism : Clinical And Experimental Research. 22. 60-66 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa, T. et. Al: "Effect of steroid on the confocal imaging of dendritic spines in the living hippocampal slice."Society for Neuroscience Abstracts. 25(1). 1269-1269 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, T. et. Al: "Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissues of the rat."Neurosci Lett.. 266. 13-16 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurasaki, M. et. Al: "Histochemical Characterization of Silver-Induced Metallothionein in Kidney of Rat."J. Inorg. Biochem.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura, N. et. Al: "Analysis of activation in anterior cingulate cortex during cognitive process of selection following somatosensory stimuli : fMRI study with elaborate task paradigms."Magnetic Resonance Imaging. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, T. et. Al: "Zinc-induced excessive glutamate rekeases mat cause accelerated senescence with defect in learning and memory in senescence accelerated mouse. Trace Elements in Man and Animal 10"Plenum Publishing Co., New York (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosokawa, T. et. Al: "Distribution of copper transported ATP7B in embryo and new born rat. Trace Elements in Man and Animal 10"Plenum Publishing Co., New York (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 齋藤 健: "環境と生体内微量元素"北海道医報生涯教育シリーズXI「環境と健康」. 917. 6-8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 齋藤 健 他: "化学物質過敏症「環境応答・適応の分子機構」"蛋白質 核酸 酵素. 44. 2529-2533 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hosokawa T., et al.: "Effect of steroid on the confocal imaging of dendritic spines in the living hippocampal slice"Society for Neuroscience Abstracts. 25(1). 1269 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakamura, N., et al.: "Analysis of activation in anterior cingulate cortex during cognitive process of selection following somatosensory stimuli : fMRI study with elaborate task paradigms"Magnetic Resonance Imaging. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 齋藤 健: "生命(いのち)-テクノロジーと論理-"北海道大学図書刊行会、札幌. (in press)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wang Yu-ping: "Alteration in hippocampal and cerebral expression of glial fibrillary acidic protein following styrene exposure in rat." Neuropathology. 18. 289-294 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡部 雅史: "Histochemical localization of superoxide dismutase in rat brain." Free Radical Biology and Medicine. 24. 1470-1476 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 齋藤 滋: "Role of metallothionein on Zn,Cu and Cd accumulation in rat liver after heavy metal injection" Trace Elements and Electrolytes. 15. 58-64 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 李 丹: "Changes in GABA metabolism in rat brain by iron deficiency." Trace Elements and Electrolytes. 15. 28-33 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 齋藤 健: "Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissues of the rat." Neuroscience Letters. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 花田 太郎: "Intra-cellular accumulation of Thallium as a maker of cisplatin cytotoxity-an application of inductively coupled plasma mass spectrometry-." Cancer. 83. 930-935 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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