| Project/Area Number |
10557045
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Public health/Health science
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| Research Institution | Tokai University |
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Principal Investigator |
OKAZAKI Isao Tokai University, School of Medicine, Professor, 医学部, 教授 (00051649)
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| Co-Investigator(Kenkyū-buntansha) |
OHSAKA Fumio Tokai University School of Medicine Assistant Professor, 医学部, 講師 (70096204)
HOZAWA Shigenari Tokai University School of MedicineAssistant Professor, 医学部, 講師 (40181482)
WATANABE Tetsu Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (10129744)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | multiple risk factor syndrome / β3adrenergic receptor / ALDH2 / liver function tests / 肝機能検査異常 / 職域健康管理 / β_3-adrenergic receptor / 脂肪肝 / インスリン抵抗性病態 / β_3-advenergic receptor |
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| Research Abstract |
Obesity, hyperlipidemia, hypertension and hyperglycemia have been known as the atherosclerotic cardiovascular risk factors. The present study was designed to clarify the relation of aldehyde dehydrogenase 2 (ALDH2) and β3-Adrenergic Receptor (β3-AR) genes and abnormal elevation of ALT supposed to be in the process of multiple risk factor syndrome, and to clarify whether the examinations of two genes and ALT are useful for the prevention of multiple risk factor syndrome. The numbers of cases with elevated ALT increased gradually according to the accumulation of cardiovascular risk factors. Active ALDH2 was significantly more associated with the elevated ALT in the supposed process of multiple risk factor syndrome than β3-AR mutation. In normal BMI group genotypes of ALDH2 and β3-AR are associated with elevated ALT.
To evaluate the genotype of ALDH2 and β3-AR may be additional and helpful way for the prediction and prevention of the multiple risk factor syndrome.
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