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Clinical application of angiogenic therapy for ischemic heart disease

Research Project

Project/Area Number 10557067
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

FUJITA Masatoshi  College of Medical Technology, KYOTO UNIVERSITY Professor, 医療技術短期大学部, 教授 (50190046)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Koji  Graduate School of Medicine, KYOTO UNIVERSITY Assistant, 大学院・医学研究科, 助手 (50283594)
TABATA Yasuhiko  Graduate School of Medicine, KYOTO UNIVERSITY Assistant Professor, 再生医科学研究所, 助教授 (50211371)
NOHARA Ryuji  Graduate School of Medicine, KYOTO UNIVERSITY Assistant Professor, 大学院・医学研究科, 講師 (80180769)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsAngiogenic therapy / bFGF / Coronary collateral vessel / Effort angina / Heparin / Counterpulsation / Gelatin gel / Myocardial ischemia / ヘパリン運動療法 / LDLアフェレーシス
Research Abstract

Angiogenic therapy is noticed as a new treatment for ischemic heart disease, which increases blood flow to the ischemic myocardium as a result of collateral development secondary to the administration of angiogenic growth factors. While the effectiveness of this treatment is reported in several canine experiments, clinical applications have been launched out in Germany and U.S.A..
We found that significant coronary collateral development is induced by the implantation of bFGF-impregnated acidic gelatin hydrogel microspheres into the infarct myocardium of dogs with acute coronary occlusion. We also found that regional wall motion abnormality is attenuated by the treatment and this treatment is useful for the preservation of ischemic myocardium. As a future clinical application, we have a plan of angiogenic therapy with use of bFGF-impregnated acidic gelatin hydrogel microspheres for patients who are refractory to medical therapy and are not a candidate for percutaneous or surgical revascularization.
EECP (enhanced external counterpulsation) as well as IABP (intra-aortic balloon pumping) increases the aortic diastolic pressure, and decreases the aortic systolic pressure resulting in the augmentation of coronary blood flow and cardiac output. We reported that 35 hours of EECP with the 5,000 U of heparin pretreatment alleviated anginal attack in a patient with effort angina. It is conceivable that EECP combined with heparin pretreatment has great potential as noninvasive treatment of angina patients.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Keisuke Shioji, et al.: "Heparin exercise treatment for a patient wirh arteriosclerosis obliterans"Japanese Chirculation Journal. 61. 715-718 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terumitsu Tanaka, et al.: "Improvement of execise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina"Journal of the American College of Cardiology. 32. 1982-1986 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Daisuke Masuda, et al.: "Improvement of regional mycardial and coronary blood flow reserve in a patient treated with enhanced external counterpulsation"Japanese Chirculation Journal. 63. 407-411 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masaki Ikemoto, et al.: "Development of an enzyme-linked immunosorbent assay for acidic fibroblast grownth factor and its clinical application"Clinica Chimica Acta. 283. 171-182 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatoshi Fujita, et al.: "Heparin potentiates cllateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion"Intemational Journal of Cardiology. 70. 165-170 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatoshi Fujita, et al.: "Heparin and angiogenic therapy"European Heart Journal. 21. 270-274 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Keisuke Shioji, et al: "Heparin exercise treatment for a patient with arteriosclerosis obliterans"Japanese Circulation Journal. 61. 715-718 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terumitsu Tanaka, et al.: "Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina."Journal of the American College of Cardiology. 32. 1982-1986 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Daisuke Masuda, et al.: "Improvement of regional myocardial and coronary blood flow reserve in a patient treated with enhanced external counterpulsation."Japanese Circulation Journal. 63. 407-411 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masaki Ikemoto, et al.: "Development of an enzyme-linked immunosorbent assay for acidic fibroblast growth factor and its clinical application."Clinica Chimica Acta. 283. 171-182 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatoshi Fujita, et al.: "Heparin potentiates collateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion."International Journal of Cardiology. 70. 165-170 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatoshi Fujita, et al.: "Heparin and angiogenic therapy."European Heart Journal. 21. 270-274 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Daisuke Masuda et al.: "Improvement of regional myocardial and coronary blood flow reserve in a patient treated with enhanced external counterpulsation"Japanese Circulation Journal. 63(5). 407-411 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masatoshi Fujita et al.: "Determinants of collateral development in patients with acute myocardial infarction"Clinical Cardiology. 22(9). 595-599 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masaki Ikemoto et al.: "Development of an enzyme-linded immunosorbent assay for acidic fibroblast growth factor and its clinical application"Clinica Chimica Acta. 283. 171-182 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masatoshi Fujita et al.: "Heparin potentiates collateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion"International Journal of Cardiology. 70. 165-170 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Atsushi Iwakura et al.: "Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis"Journal of the American College of Cardiology. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masatoshi Fujita et al.: "Heparin and angiogenic therapy"European Heart Journal. 21. 270-274 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Keisuke Shioji: "Heparin exercise treatment for a patient with arteriosclerosis obliterans." Japanese Circulation Journal. 61(8). 715-718 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masatoshi Fujita: "Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris." Angiogenesis. 2(1). 105-108 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Terumitsu Tanaka: "Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina." Journal of the American College of Cardiology. 32(7). 1982-1986 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoko Yamamoto: "Antomatic processing of myocardial contrast echocardiograms of intravenous injection of contrast." Annual Reports of the College of Medical Technology, Kyoto University. in press. (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lee Linxue: "Effect of long-term exercise training on regional myocardial perfusion changes in patients with coronary artery disease." Japanese Circulation Journal. 63(2). 73-78 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masatoshi Fujita: "Determinants of collateral development in patients with acute myocardial infarction." Clinical Cardiology. (in press). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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