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The causative genes for allergy and clinical use.

Research Project

Project/Area Number 10557075
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Pediatrics
Research InstitutionGifu University

Principal Investigator

KONDO Naomi  Gifu University School of Medicine, Professor, 医学部, 教授 (50124714)

Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1999: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1998: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywordsatopy / allergy / IL-12 receptor / IL-18 receptor / I ε region / インターロイキン18レセプタ / インターロイキン12レセプター / インターロイキン18レセプター / インターロイキン12
Research Abstract

The causative genes of allergy have been newly found and have been structurally analyzed.
(1) In B cells
I ε region, S ε region and C ε region of Ig gene have been analyzed in the patients with allergy. As a result, it becomes clear that chromatin of I ε region is more open in the patients with allergy.
(2) In T cells
The mutations of IL-12 receptor β2 chain gene have been identified as one of the causative genes for allergy. Some patients with high levels of IgE production had the mutations of IL-12 receptor β2 chain gene. IL-12 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations induced high levels of IgE production and allergic reactions.
Next, the mutations of IL-18 receptor α2 chain gene have been identified as the causative gene for allergy. Some patients with high levels of IgE production had the mutations of IL- 18 receptor α2 chain gene. IL-18 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations also induced high levels of IgE production and allergic reactions.
Moreover, we have published the information of structure of IL-18 protein by NMR.
Furthermore, we have published the genetical classification of atopy for clinical or prevention of allergy.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Kaneko H,Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Exp Immunol. 118. 285-289 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tashita H,Kondo N, et al.: "Molecular basis of selective IgG2 deficiency : The mutated membrane-bound from of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders.-6-year follow-up study."Clin Exp Allergy. 28. 1340-1344 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Atopy and mutations of IL-12 receptor β2 chain gene."Clin Exp Allergy. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukao T,Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsui E,Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun. 266. 551-555 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Role of IL-12 receptor β2 mutations in development of atopy."Allergy & Clinical Immunology International. 92-94 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 近藤直実: "分子アレルギー学:アトピーとIgE遺伝子"メディカルレビュー社. 599 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaneko H, Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Exp Immunol. 118. 285-289 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tashita H, Kondo N, et al.: "Molecular basis of selective IgG2 deficiency : The mutated membrane-bound form of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders.-6-year follow-up study."Clin Exp Allergy. 28. 1340-1344 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Atopy and mutations of IL-12 receptor β2 chain gene."Clin Exp Allergy. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukao T, Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matsui E, Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun.. 266. 551-555 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kondo N, et al.: "Role of IL-12 receptor β2 mutations in development of atopy."Allergy & Clinical Immunology International. Supple 1. 92-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaneko H,Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Exp Immunol. 118. 285-289 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tashita H,Kondo N, et al.: "Molecular basis of selective IgG2 deficiency : The mutated membrane-bound form of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders-6-year follow-up study."Clin Exp Allergy. 28. 1340-1344 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kondo N, et al.: "Role of IL-12 receptor β2 mutations in development of atopy."Allergy & Clinical Immunology International. Suppl 1. 92-94 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukao T,Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsui E,Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun. 266. 551-555 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kondo N, et al.: "Atopy and mutations of IL-12 receptor β2 chain gene."Clin Exp Allergy(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 近藤直実: "分子アレルギー学:アトピーとIgE遺伝子"メディカルレビュー社. 599 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kaneko H, Kondo N, et al.: "Expression of the BLM gene in human haematopoietic cells."Clin Esp Immunol. 118. 285-289 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tashita H, Kondo N, et al.: "Molecular basis of selective IgG2 deficiency: The mutated membrane-bound from of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings."J Clin Invest. 101. 677-681 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kondo N, et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders. -6-year follow-up study."Clin Exp Allirgy. 28. 1340-1344 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Orii Ke, Kondo N, et al.: "Genes for the human mitochondrial trifunctional protein α-and β-subunits are divergently transcribed from a common promoter region."J Biol Chem. 274. 8077-8084 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukao T, Kondo N, et al.: "ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells."Blood. 94. 1998-2006 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsui E, Kondo N, et al.: "Mutations of the IL-12 receptor β2 chain gene in some atopic subjects."Biochem Biophy Res Commun. 266. 551-555 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 近藤直実: "現代内科学:原発性免疫不全症候群(1)抗体不全を主とする疾患"金芳堂. 2384 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 近藤直実: "分子アレルギー学:アトピーとIgE遺伝子"メディカルレビュー社. 599 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kondo N et al: "Cord blood lymphocyte responses to antigens for the prediction of allergy" Pediatric Asthma Allergy & Immunology. 12. 61-66 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kondo N et al: "DNase I hypersensitive sites in himan Iε reyion of immunolobulin heary chain genes abnomally induced by interleukn4 in Blymphocytes of atopic patients with high levels of serum IgE" J Invest Allergol & Clin Immunol. 8. 234-238 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kaneko H, Kondo N et al.: "BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear lacalisation Signal" Biochem Biophysical Res Commun. 240. 348-353 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tashita H, Kondo N et al: "Molecular basis of selective IgG2 deficiency : The mutatid membrane-bound form of γ2 heavy chain caused complete IgG2 deficiency in two Japanese siblings" J Clin Invest. 101. 677-681 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukao T, Kondo N et al: "Atayia telangiectasia in the Japanese population : identification of R1917X,W2491R,R2909G,IVS33+2T+A,and 788del5,the latter two being relatively common mutations." Hum Mutat. 12. 338-343 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kondo N et al.: "Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders-6-year follow-up study." Clin Exp Allergy. 28. 1340-1344 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 近藤直実: "現代内科学:原発性免疫不全症候群(1)抗体不全を主とする疾患" 金芳堂, 2384 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 近藤直実: "分子アレルギー学:アトピーとIgE遺伝子" メディカルレビュー社, 599 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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