• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chronic umbilical cord compression and intrauterine growth retardation

Research Project

Project/Area Number 10557098
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Embryonic/Neonatal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

KOZUMA Shiro (2000-2001)  The University of Tokyo, Obstetrics & Gynecology, A. Professor, 医学部・附属病院, 助教授 (10272569)

海野 信也 (1998-1999)  東京大学, 医学部・附属病院, 講師 (90193979)

Co-Investigator(Kenkyū-buntansha) MARUMO Genzo  The University of Tokyo, Obstetrics & Gynecology, Research Associate, 医学部・附属病院, 助手 (60282646)
BABA Kazunori  The University of Tokyo, Medical Engineering, A. Professor, 大学院・医学系研究科, 助教授 (30181035)
上妻 志郎  東京大学, 医学部・附属病院, 助教授 (10272569)
Project Period (FY) 1998 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1999: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1998: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordsumbilical cord / fetal sheep / hemodynamics / 子宮内胎児発育障害 / 胎仔 / 臍帯 / 血流 / 内分泌 / 循環
Research Abstract

In order to clarify the effect of chronic umbilical cord compression on fetal growth, we characterized the detailed hemodynamics of fetal blood pressure, heart rate, umbilical blood flow and carotid blood flow responses to partial umbilical cord compression. In chronically instrumented fetal sheep at 120-130 days of gestation, partial compression of the umbilical cord was induced 15 times, each for 2 min at 2 min intervals. Each cord copression reduced umbilical blood flow by 50%.
The data obtained in this study has been under investigation.

Report

(5 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Uemura H: "A movable gestational sac in association with a myometrial defect"Ultrasound Obstet Gynecol. 18(6). 675-677 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroi H: "Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder"Arch Gynecol Obstet. 265(4). 228-230 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida SH: "Sonographic determination of fetal size from 20 weeks of gestation onward correlates with birth weight"J Obstet Gynaecol Res. 27(4). 205-211 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanai T: "Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood"Am J Reprod Immunol. 45(2). 94-99 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujii T: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to, in the treatment of autoimmunity-related recurrent abortion"Am J Reprod Immunol. 44(6). 342-346 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kuroda K: "Prenatal evaluation of cephalopagus conjoined twins by means of three-dimensional ultrasound at 13 weeks of pregnancy"Ultrasound Obstet Gynecol. 16(3). 264-266 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida SH: "Sonographic detemination of fetal size from 20 weeks of gestation onward correlates with birth weight"J Obstet Gynaecol Res.. 27(4). 205-211 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uemura H.: "Amcable gestational Sac in association with a myometrial defect"Ultrasound Obstet Gynecol. 18(6). 675-677 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroi H.: "Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder"Arch Gynecol Obstet. 265(4). 228-230 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanai T.: "Human leukocyte artigen-G-expressing Cells differently modulate the releass of cytokines from monoiruclear cells present in the decidua versus ponipheml blood"Am J Reprod Immunol. 45(2). 94-99 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujii T.: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to in the treatment of antoimmuhity-related"Am J Reprod Immuol. 44(6). 342-346 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kuroda K.: "Prenatal evalutation of cephalopagus Conjolned twins means of three-dimensional ultlasound at 13 weeks of pregnancy"16(3). 264-266 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uemura H: "A morable gestational sac in association with a myometrial defect"Ultrasound Obstet Gynecol. 18(6). 675-677 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiroi H: "Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder"Arch Gynecol Obstet. 265(4). 228-230 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshida SH: "Sonographic determination of fetal size from 20 weeks of gestation onward correlates with birth weight"J Obstet Gynaecol Res. 27(4). 205-211 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kanai T: "Human leukocyte antigen-G-expressing cells differently modulate the rekase of cytokines from mononuclear cells present in The decidua versus peripheral blood"Am J Reprod Immunol. 45(2). 94-99 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujii T: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Soirei-to, in the treatment of autoimmunity-related recurrent abortion"Am J Reprod Immunol. 44(6). 342-346 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuroda K: "Prenatal evaluation cephalopagus conjolned twins by means of three-dimensional ultrasound at 13 weeks of pregnancy"Ultrasound Obstet Gynecol. 16(3). 264-266 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] G.Manuno,S.Kozuma, et al: "Generation of Periventricular feukomalacia by Repeated Umbilical Cord Occlusion in New-Term Fetal Sheep and its Possible Pathogenetical Mechanisms"Biology of the Neonate. 79(1). 39-45 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Unno N,et al.: "Blood Pressure and Heart Rate in the Ovine Fetus : Ontogenic Changes and Effects of Fetal Adrenalectomy"Am J Physiol. 276. H248-H256 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kozuma S,Unno N.et al.: "Goat fetuses disconnected from the placenta, but reconnected to an artificial placenta,display intermittent breathing movements"Biol Neonate. 75. 388-397 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wu WX, Unno N,et al.: "Suppression Subtractive Hybridization Identifield a Marked Increase in Thrombospondin-1 Associated with Partutrition in Pregnant Sheep Myometrium"Endocrinology. 140. 2364-2371 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ryo E,Unno N,et al.: "Inferior vena cava diameter and the risk of pregnancy-induced hypertension and fetal compromise"Int J Gynerol Obstet. 65. 143-148 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wu WX,Unno N,et al.: "Characterization of decorin mRNA in pregnant intrauterine tissues of the ewe and regulation by steroids"Am J.Physiol. 278. C199-C206 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshida S,Unno.N,et al.: "Prenatal detection of a high risk group for intrauterine growth restriction based on sonographic fetal biometry"Int J Gynecol Obstet. 66(in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] UNNO N,et al: "Prostaglandin regulation of fetal plasma adrenocorticotropin and cortisol concentrations in late gestation sheep." Biology of Reproduction. 58. 514-519 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] UNNO N,et al: "The effects of fetal adrenalectomy at 110 days gestational age on AVP and CRH mRNA expression in the hypothalamic paraventricular nucleus of the ovine fetus." Brain Research : Developmetal Brain Research. 106. 119-128 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] UNNO N et al: "Metabolic and endocrine responses to cold exposure in chronically-incubated extrauterine goat fetuses." Pediatric Research. 43. 452-460 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] WU WX,UNNO N,et al: "Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in the pregnant sheep." Endocrinology. 139. 3096-3103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] UNNO N,et al: "Blood Pressure and Heart Rate in the Ovine Fetus: Ontogenic Changes and Effects of Fetal Adrenalectomy." American Journal of Physiology. 276. H248-H256 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ryo E,Unno N.et al: "Inferior vena cava diameter and the risk of pregnancy-induced hypertension and fetal compromise." International Journal of Gynecology and Obstetrics. (in press). (1999)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi