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Development of new composition of peritoneal savage fluids

Research Project

Project/Area Number 10557117
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Digestive surgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SHINEHA Ryuzaburo  Tohoku University Hospital, Lecturer, 医学部・附属病院, 講師 (20192106)

Co-Investigator(Kenkyū-buntansha) TERASAWA Takayuki  Tohoku University Hospital, Research Associate, 医学部・附属病院, 助手 (10292319)
SAYAMA Junzo  Tohoku University Hospital, Research Associate, 医学部・附属病院, 助手 (60292322)
MIYAZAKI Syukichi  Graduate Sch. of Medicine, Tohoku Univ., Research Associate, 大学院・医学系研究科, 助手 (50282075)
ITOH Tsunetoshi  Graduate Sch. of Medicine, Tohoku Univ., Professor, 大学院・医学系研究科, 教授 (90004746)
TAMURA Shinri  Graduate Sch. of Medicine, Tohoku Univ., Professor, 大学院・医学系研究科, 教授 (20124604)
知久 一雄  テルモ研究開発センター, 主任
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordssalt solution / peritoneal lavage / CAPD / cytokine / IL-6 / 生理的食塩水 / 侵襲
Research Abstract

The purpose of this study is to determine the composition of the ideal peritoneal lavage fluid which makes no damage of peritoneum and organs, and also reduces the excessive reaction of mediators by irrigation of peritoneal cavity.
Experimental model of rats for peritoneal lavage was established by modified CAPD procedure and composition was determined as follows : Na 140mM, K, 103mM, Cl 103mM, Mg 0.5mM, Ca 1mM, Lactate 44mM, Glucose 5g/L,PH 7.4, Osm 305mOsm/kg.
This solution made less production of cytokines(Il-6 etc.) and electrolytes movement from peritoneal cavity to plasma, and peritoneal damage (examined by PEG 4000) comparing with saline. Such conventional lavage by saline made tissue damage and production of mediators.
This new solution may also make the stable circulatory condition of patients and prevention of adhesion of tissues.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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