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Attachments of a Tip-Angling Device and a Working Channel : Development of the Multipurpose Ultrafine Spinal Fiberscope

Research Project

Project/Area Number 10557137
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

SHIMOJI Koki  SCHOOL OF MEDICINE, NIIGATA UNIVERSITY PROFESSOR, 医学部, 教授 (30040158)

Co-Investigator(Kenkyū-buntansha) KUROKAWA Satoshi  UNIVERSITY MEDICAL HOSPITAL, NIIGATA UNIVERSITY, ASSISTANT, 医学部・附属病院, 助手 (20303117)
TOMITA Misao  UNIVERSITY MEDICAL HOSPITAL, NIIGATA UNIVERSITY, LECTURER, 医学部・附属病院, 講師 (60221438)
飛田 俊幸  新潟大学, 医学部・附属病院, 助手 (80262442)
福田 悟  新潟大学, 医学部, 助教授 (30116751)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1998: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordsfiberscope / ultrafine / angling / working channel / drug administration / surgical manipulation / recording physiological events / visual quality
Research Abstract

The methods for the attachments to the ultrafine fiberscope of a tip-angling device and a working channel of multipurpose uses, such as recording of physiological events, drug administrations and surgical interventions, were studied during this fiscal year.
Fine flexible fiberscopes make it possible to visualize the entire length of the spinal subarachnoid space. However, further access and interventions to the intended structures in the spinal canal have been impossible because of the difficulty of equipping such a fine fiberscope with a tip-angling device and a working channel. Here, we developed fine flexible fiberscopes(1.47 and 1.50 mm in diameter)equipped with a tip-angling device and a working channel. Epidural and subarachnoid spaces were accessed with these fiberscopes in nine pain patients and one patient who underwent subarachnoid cystectomy. The epidural and subarachnoid spaces were easily approached and clearly visualized in all 10 patients without major complications. The fiberscope also reached the epiarachnoid space in all 6 cases tested. The surface of the cord was more clearly observed by angling the tip. Accurate positioning of the tip to a thoracic spinal root was successful in 4 of 5 cases tested. During manipulation of the epidural space, 4 patients noticed root pain ; this pain disappeared following regional injection of 3 ml of 0.5 % lidocaine through a working channel. In two patients, the spinal cord potential from the epidural space was successfully recorded using an electrode inserted through the working channel during step-by-step withdrawal of the fiberscope. Thus, percutaneous interventions to the spinal structures in the epidural and subarachnoid spaces of the pain patients can be achieved using a fine flexible fiberscope with a tip-angling device and a working channel.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (49 results)

All Other

All Publications (49 results)

  • [Publications] Aida S, 他: "Involvement of presurgical pain in preemptive analgesia for orthopedic surgery : a randomized double blind study"Pain. 84・2-3. 169-173 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 飛田俊幸, 他: "手術操作による医原性の神経学的症状悪化をいかに防ぐか"LiSA. 6. 1206-1211 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 飛田俊幸, 他: "術中脊髄機能モニタリングの現況と問題点"臨床脳波. 42・6. 347-352 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 下地恒毅、他: "脊髄腔内ファイバースコープの現況と将来"神経麻酔・集中治療研究会(第3回日本神経麻酔研究会プロシーディング). 3. 1-4 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ataka T, 他: "Baclofen inhibits more effectively C-afferent than A-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat cord slices"Pain. 86・3. 273-282 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida S, 他: "Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy A randomized double-blind study"Anesthesiology. 92・6. 1624-1630 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hayatus K, Tomita M, Denda S, Endoh H, Shimoji K: "Epidural spinal cord stimulation(ESCS)in patient with disturbance of consciousness."Jpn J Reanimatol. 17(1). 50-53 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimoji K, Tobita T, Denda S, Tomita M, Kano T: "Effects of anesthetics on somatosensory and motor-evoked spinal cord potentials."7^<th> International Symposium on Spinal Cord Monitoring(Wednes day Friday, march 18-20, 1998, Osaka, Japan). 7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Baba H, Kohno T, Okamoto M Gldstein PA, Shimoji K, Yoshimura M: "Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn."J Physiol. 508(1). 83-93 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimoji K, Denda S, Tobita T, Endoh H: "Perioperative neurological monitoring."The 10th Asian Australasian Congress of Anaesthesiologists(May 10-14, 1998, Taipei, Taiwan), SF1, 1998(Abstracts).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimoji K: "Development of a fine fiberscope system for observation of subarachnoid and epidural tissue blood flow and metabolism."Innervision. 13(9). 27 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchiyama S, Hasegawa K, Homma T, Takahashi HE, Shimoji K: "Ultrafine flexible spinal endoscope(myeloscope)and discovery of an unreported subarachnoid lesion."Spine. 23(21). 2358-2362 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tomita M, Shimoji K: "Somatosensory evoked potentials."In : For doctors Involved in Anesthesiology and Physiology Related to Anesthesia, hanaoka K(ed), Shinko-koueki Isho-shuppan, Tokyo. 251-260 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kohno T, Ataka T, Okamoto M, Yoshimura M, Shimoji K: "Pain inhibitory mechanism of midozolam in spinal cord substantia gelatinosa."Neuroanesthesia and Critical Care 1998(Procceing : the 2nd annual meeting of Jpn Soc Neuroanesthesia and Critical Care). 31-33 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Denda S, kurokawa S, kinoshita H, Tobita T, Tomita M, Fukuda S, Shimoji K: "Spinal cord monitoring with EEP, ACP and MEP during surgical operations on thoracic and thoracoabdominal anenrysm."Neuroanesthesia and Critical Care 1998(Procceing : the 2nd annual meetin of Jpn Soc Neuroanesthesia and Critical Care). 64-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Belova OA, Uchiyama S, Yajiri Y, Takahashi HE, Shimoji K: "Spinal cord monitoring in spinal surgery : two demonstrative cases."Acta Med Biol. 47(2). 81-84 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ataka T, Okamoto M, Kohno T, Baba H, Shimoji K: "Midazolam enhances GABAA-induced inhibitory effects in substantia gelationosa in rat spinal cord."J Electrodiagnosis Spnal Cord. 20(1). 9-12 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida S, Shimoji K: "Homogenous mixing of propofol emulsion into an infusion solution."Anaesthesia. 54(7). 716-717 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kohno T, Kumamoto E, Higashi H, Shimoji K, yoshimura M: "Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord."J Physiol. 518(3). 803-813 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tobita T, Shimoji K: "How to minimize iatrogenic neurological sequelae caused by the surgical manipulations."LiSA. 6(12). 1206-1211 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida S, Fujihara H, Taga K, Fukuda S, Shimoji K.: "Involvement of presurgical pain in preemptive analgesia for orthopedic surgery : a randomized double blind study."Pain. 84(2-3). 169-173 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Baba H, Shimoji K, Yoshimura M: "Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord(part 1)-Effects on axon terminals of GABAergic and glycinergic neurons-."Anesthesiology. 92(2). 473-484 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Baba H, Goldstein PA, Okamoto M, Kohno T, Ataka T, Yoshimura M, Shimoji K: "Norepinephrine facilitates inhibitory transmission in substantia gelationosa of adult rat spinal cord(part 2)-Effects on somatodendritic sites of GABAergic neurons-."Anesthesiology. 92(2). 485-492 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tobita T, Tomita M, Shimoji K: "Intraoperative spinal cord monitoring ; the present situation with its problems."Clin Electroencephal. 42(6). 347-352 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Kumamoto E, Shimoji K, Yoshimura M.: "Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices."Pain. 86(3). 273-282 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida, Yamakura T, Baba H, Taga K, Fukuda S, Shimoji K: "Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy. A randomized double-blind study."Anesthesiology. 92(6). 1624-1630 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida S, Shimoji K: "Preemtive analgesia with epidural and intravenous ketamine in combination with epidural blockade in abdominal surgery."In New Balanced Anesthesia, Mori K, Ohmura A, Toyooka H, Shingu K, Fukuda K(eds), Elsevier Science BV, Amsterdam. 345-346 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Denda s, Tomita M, Tobita T, Taga K, Fukuda S, Shimoji K: "Effects of isoflurane on the spinal cord potentials by transcranial electric stimulation."In Recent Advances in Human Neurophysiology, Hashimoto I, Kakigi R(eds), Elsevier Science BV, Amsterdam. 1022-1026 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tobita T, Denda S, Takada T, Endoh H, Baba H, Yamakura T, Fukuda S, Shimoji K: "Effects of fentanyl on spinal cord potentials and electromyogram evoked by transcranial magnetic stimulation in man."In Recent advances in Human Neurophysiology, Hashimoto I, Kakigi R(eds), Elsevier Science BV, Amsterdam. 1034-1037 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimoji K, Yamakura T, Baba H, Aida S: "Role of NMDA receptors in pain and anesthesia."In Regional anaesthesia and pain management current perspecitives, GP Dureja, R Modan, HL Laul(eds), Churchill Livingstone, New Delhi. 63-70 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida S 他: "Involvement of presurgical pain in preemptive analgesia for orthopedic surgery : a randomized double blind study"Pain. 84・2-3. 169-173 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 飛田俊幸 他: "手術操作による医原性の神経学的症状悪化をいかに防ぐか"LiSA. 6. 1206-1211 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 飛田俊幸 他: "術中脊髄機能モニタリングの現況と問題点"臨床脳波. 42・6. 347-352 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 下地恒毅 他: "脊髄腔内ファイバースコープの現況と将来"神経麻酔・集中治療研究会(第3回日本神経麻酔研究会プロシーディング). 3. 1-4 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ataka T 他: "Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelationsa neurons of adult rat spinal cord slices"Pain. 86・3. 273-282 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Aida S 他: "Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy A randomized double-blind study"Anesthesiology. 92・6. 1624-1630 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Baba H, 他: "Norepinephrine facilitaties inhibitory transmission in substantia gelatinosa of adult rat spinal cord (Part 1)"Anesthesiology. 92.2. 473-484 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Baba H, 他: "Norepinephrine facilitaties inhibitory transmission in substantia gelatinosa of adult rat spinal cord (Part 2)"Anesthesiology. 92.2. 485-492 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohno T, 他: "Actions Midazolam on GABAergic transmission in substantia gelatinosa Neurons of adult rat spinal cord"Anesthesiology. 92.2. 507-515 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Uchiyama S, 他: "Ultrafine flexible spinalendoscope (myeloscope) and discovery of an unreported subarachnoid lesion"Spine. 23.21. 2358-2362 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimoji K, 他: "Measurement of subarachnoid blood flow changes with a laser doppler fibereoptic probe in anaesthetized dogs"Proceeding of 9th World Congress on Pain, 1999, IASP press. p384 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohno T, 他: "Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord"J Physiology. 518.3. 803-813 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 下地恒毅 他: "微小光ファイバーを用いたクモ膜下・硬膜外組織血流代謝モニターシステムの開発" インナービジョン. 13.9. 27 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamakura T他: "Sensitivity of the N-methl-D-asparte receptor channel tobutyrophenones is dependent on the ε_2 subunit" Neurophamacology. 37.6. 709-717 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 早津恵子 他: "意識障害患者に対する硬膜外脊髄通電療法" 蘇生. 17.1. 50-53 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 吉村 恵 他: "アロディニアの機序" 日本ペインクリニック学会誌. 5.2. 104-111 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Baba H 他: "Muscarinic facilitation of GABA release in substantia gelationsa of the rat spinal dorsal horn" Journal of Physiology. 508.1. 83-93 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Denda S 他: "Recent Advances in Human Neurophysiology" Hashimoto I,Kakigi R(eds), 5 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tobita T 他: "Recent Advances in Human Neurophysiology" Hashimoto I,Kakigi R(eds), 4 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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