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The specific and rapid assay of inhibin and its clinical applications

Research Project

Project/Area Number 10557146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Obstetrics and gynecology
Research InstitutionGunma University

Principal Investigator

IBUKI Yoshito  Gunma Univ. Sch. Med. Dept. OB/GYN., Prof., 医学部, 教授 (40008256)

Co-Investigator(Kenkyū-buntansha) ANDOH Kazumichi  Gunma Univ. Sch. Med. Dept. OB/GYN., Assistant Professor, 医学部, 講師 (20232093)
MIZUNUMA Hideki  Gunma Univ. Sch. Med. Dept. OB/GYN., Associate Professor, 医学部, 助教授 (10125875)
ABE Yumiko  Gunma Univ. Sch. Med. Dept. OB/GYN., Research Associate, 医学部, 助手 (70261857)
MASHIMO Ikuo  Teijin SRL Labotatory, INC. Director of the board, General Manager Clinical Chemistry Lab, 研究検査部, 担当次長
HASEGAWA Yoshihisa  Kitasato Univ. Sch. Vet. Med. Anim. Sci., Prof., 獣医畜産学部, 教授 (40092001)
眞下 郁男  (株)エスアールエル, 研究検査部, 担当次長
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsInhibin / Assay / Clinical Applications
Research Abstract

The anti-inhibin polyclonal antibody used in our RIA reacts with inhibin A, inhibin B, and inhibin α-monomer. Our inhibin RIA system estimates the amount of inhibin B more accurately than Monash RIA and the pattern of IR-inhibin during normal cycle reflects both inhibin A and inhibin B. We improved the sensitivity of this assay system by changing the buffer and iodination methods and obtained the minimum detection level with 0.1 IU/ml. Using this assay system, IR-inhibin levels in various clinical samples were measured. Serum IR-inhibin levels of patients with granulosa cells reflect the clinical conditions. IR-inhibin levels dropped below the detectable limit after total removal of the tumor in these patients and increased earlier in the case of relapse than other tumor markers. IR-inhibin increased earlier than inhibin A or inhibin B in the patient who manifested OHSS among women undergoing ovulation induction by ganadotropins. Therefore there is the possibility that IR-inhibin is a good marker of hyperstimulation of the ovaries. IR-inhibin was below the sensitivity level among women over 60 years old. The study of a large number of samples from women over 60 years old is ongoing, in order to determine whether IR-inhibin is suitable as a tumor marker or not.
We also developed inhibin A immunofluorometric assay and the study of inhibin A during pregnancy measured by this assay is continuing. The anti inhibin B antibody which was developed was not suitable for immunofluorometric assay.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (86 results)

All Other

All Publications (86 results)

  • [Publications] Mizunuma H.: "Activin from secondary follicles causes small preantral follicles to remain dormant at the resting stage"Endocrinology. 140(1). 37-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma H.: "Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome"Hum-Reprod. 13(10). 2816-2818 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Igarashi M.: "Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis"Hum-Reprod. 13(7). 1952-1956 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Andoh K.: "A comparative study of fixed-dose, step-down, and low-dose step-up regimens of human menopausal gonadotropin for patients with polycystic ovary syndrome"Fertil-Steril. 70(5). 840-846 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iizuka M.: "Chemical assay of iron in ovarian cysts : a new diagnostic method to evaluate endometriotic cysts"Gynecol-Obstet-Invest. 46(1). 58-60 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurihara T.: "Determination of a normal level of serum CA125 in postmenopausal women as a tool for preoperative evaluation and postoperative surveillance of endometrial carcinoma"Gynecol-Oncol. 69(3). 192-196 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroi H.: "An Earlier Menopause as Clinical Manifestation of Granulosa-Cell Tumor : A Case Report"J. Obstet. Gynecol. Res.. 26(1). 9-12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimizu H.: "Orchiectomy and response to testosterone in the development of obesity in young Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats"Int-J-Obes-Relat-Metab-Disord. 22(4). 318-324 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurai H.: "Placental metastasis from maternal primitive neuroectodermal tumor"Am-J-Clin-Oncol. 21(1). 39-41 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 宮路幸隆: "内分泌疾患臨床の新しい展開"内科. 85. 126-139 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "閉経女性の高脂血症とhormone replacement therapy (HRT)"Medical Paractice. 16(3). 479-481 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "多嚢胞性卵巣症候群(PCOS)"臨床婦人科産科. 53(2). 178-179 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Liu X.: "The relationship between the number of growing follicles and the occurrence of Multiple pregnancies in women treated with gonadotropin"Jpn. J. Fertil. Steril. 44(3). 213-219 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "女性における加齢現象,特に更年期における変化"Modern Physician. 18(9). 1007-1010 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "多嚢胞性卵巣症候群(PCOS)に対する排卵誘発と卵巣過剰刺激症候群(OHSS)予防"日本産科婦人科学会雑誌・研修コーナー. 50(9). N242-N245 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安部由美子: "妊娠とアクチビン、インヒビン"Hormone Frontier in Gynecology. 5(1). 63-71 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "更年期のデータベース -HRTを含む欧米のデータをどのように本邦婦人に適用するのか?-"Progress in Medicine. 18(1). 39-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "目で見る多嚢性卵巣症候群の診断と治療"HORMONE FRONTIER IN GYNECOLOGY. 5(1). 2-5 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 関守利: "ARTにおける難治症例のスクリーニングと治療法"産婦人科の実際. 48巻2号. 333-342 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安部由美子: "インヒビン、アクチビン、フォリスタチン"生殖内分泌分科会NEWSLETTER. No.3. 12-13 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高取修: "直接法による血中エストロン測定法の検討"核医学技術. 18(1). 3-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 伊吹令人: "最適排卵法の確立"厚生省相心身障害研究 不妊治療の在り方に関する研究. 144-160 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshimura S.: "Stage-specific distributions of inhibin a-subunit in bovine ovarian follicles and and various hormone levels in follicular fluid"J. Reprod. Develop. 45. 213-222 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yada H.: "Role of ovarian theca and granulosa cell interaction in hormone production and cell growth during the bovine follicular maturation process"Biol. Reprod. 61. 1480-1486 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang D.: "Mutation analysis of the Smad3 gene in human ovarian cancers"International Journal of Oncology. 15. 945-953 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "閉経期 「最新骨粗鬆症」 (折茂 肇編)"ライフサイエンス出版,東京. 4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma H.: "Frontiers in Endocrinology vol.21 Ovarian Function Research"Serono Symposia Publications. 7 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安藤一道: "流・早産、子宮外妊娠 新女性医学大系15不妊・不育 (武谷雄二総編集)"中山書店、東京. 12 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 水沼英樹: "エストロゲン プラクティカル内科シリーズ4骨粗鬆症 (松本俊夫編)"南江堂、東京. 4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安部由美子: "新女性医学大系12 排卵と月経 武谷雄二総編集、青野敏博、麻生武志、中野仁雄、野澤志朗編集、岡村均担当編集 インヒビン、アクチビン、フォリスタチン"中山書店 (東京). 18 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安藤一道: "排卵障害の症状とその治療 新女性医学大系13排卵障害 (武谷雄二総編集)"中山書店、東京. 12 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasegawa Y.: "Proceeding of International Workshop on Embryogenetsis and Implantation"Inhibins,activins and follistatins ; Novel regulators for the follicle development and oocyte growth(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 安部由美子: "産婦人科の世界 第50巻 冬季増刊号 卵巣-機能と病態生理-インヒビン、アクチビン、フォリスタチン"医学の世界社. 68-76 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma, H: "Activin from secondary follicles causes primary follicles to remain dormant at the preantral stage."Ovarian Function Research. 241-247 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Liu, X: "The relationship between the number of growing follicles and the occurrence of Multiple pregnancies in women treated with gonadotropin."Jpn. J. Fertil. Steril. 44(3). 213-219 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iizuka-M: "Chemical assay of iron in ovarian cysts : a new diagnostic method to evaluate endometriotic cysts."Gynecol-Obstet-Invest.. 46(1). 58-60 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma-H: "Activin from secondary follicles causes small preantral follicles to remain dormant at the resting stage."Endocrinology. jan. 140(1). 37-42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma, H: "Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome."Hum-Reprod. Oct.. 13(10). 2816-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Igarashi-M: "Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis."Hum-Reprod. Jul. 13(7). 1952-6 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Andoh-K: "A comparative study of fixed-dose, step-down, and low-dose step-up regimens of human menopausal gonadotropin for for patients with polycystic ovary syndrome."Fertil-Steril. Nov. 70(5). 840-6 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurihara-T: "Determination of a normal level of serum CA125 in postmenopausal women as a tool for preoperative evaluation and postoperative surveillance of endometrial carcinoma."Gynecol-Oncol. Jun. 69(3). 192-6 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Okano-H: "The long-term effect of menopause on postmenopausal bone loss in Japanese women : results from a prospective study."J-Bone-Res. Feb. 13(2). 303-9 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimizu-H: "Orchiectomy and response to testosterone in the development of obesity in young Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats."Int-J-Obes-Relat-Metab-Disord. Apr. 22(4). 318-24 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurai-H: "Placental metastasis from maternal primitive neuroectodermal tumor."Am-J-Clin-Oncol. Feb. 21(1). 39-41 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshimura S: "Stage-specific distributions of inhibin a-subunit in bovine varian follicles and various hormone levels in follicular fluid."J. Reprod. Develop.. 45. 213-222 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yada H: "Role of ovarian theca and granulosa cell interaction in hormone production and cell growth during the bovine follicular maturation process."Biol. Reprod.. 61. 1480-1486 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasegaw Y: "Inhibins, activins and follistatins ; Novel regulators for the follicle development and oocyte growth."Proceeding of International Workshop. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizunuma-H: "Active from secondary follicles causes small preantral follicles to remain dormant at the resting stage"Endocrinology. 140(1). 37-42 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizunuma-H: "Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity sindorome"Hum-Reprod. 13(10). 2816-2818 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Igarashi-M: "Novel vaginal danazol ring therapy for pelvic endometriosis,in particular deeply infiltrating endometriosis"Hum-Reprod. 13(7). 1952-1956 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Andoh-K: "A comparative study of fixed-dose, step-down,and low-dose step-up regiments of human menopausal gonadotropin for patients with polycystic ovary syndrome"Fertil-Steril. 70(5). 840-846 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iizuka-M: "Chemical assay of iron in ovarian cysts: a new diagnostic method to evaluate endometriotic cysts"Gynecol-Obstet-Invest. 46(1). 58-60 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kurihara-T: "Determination of a normal level of serum CA125 in postmenopausal women as a tool for preoperative evaluation and postoperative surveillance of endometrial carcinoma"Gynecol-Oncol. 69(3). 192-196 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroi H: "An Earlier Menopause as Clinical Manifestation of Granulosa-Cell Tumor: A Case Report"J. Obstet. Gynecol. Res. 26(1). 9-12 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu-H: "Orchiectomy and response to testosterone in the development of obesity in young Otsuka-Long-Evans-Tokushima Fatty ( OLEFT)rats"Int-J-Obes-Relat-Metab-Disord. 22(4). 318-324 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakurai-H: "Placental metastasis from maternal primitive neuroectodermal tumor"Am-J-Clin-Oncol. 21(1). 39-41 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 宮地幸隆: "内分泌疾患臨床の新しい展開"内科. 85. 126-139 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "閉経女性の高脂血症とhormone replacement therapy(HRT)"Medical Practice. 16(3). 479-481 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "多襄胞性卵巣症候群(PCOS)"臨床婦人科産科. 53(2). 178-179 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu,X: "The relationship between the number of growing follicles and the occurrence of Multiple pregnancies in women treated with gonadotropin"Jpn. J. Fertil. Steril. 44(3). 213-219 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "女性における加齢現象,特に更年期における変化"Modern Physician. 18(9). 1007-1010 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "多襄胞性卵巣症候群(PCOS)に対する排卵誘発と卵巣過剰刺激症候群(OHSS)予防"日本産科婦人科学会雑誌・研修コーナー. 50(9). N242-N245 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 安部由美子: "妊娠とアクチビン、インヒビン"Hormone Frontier in Gynecology. 5(1). 63-71 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "更年期のデータベース -HRTを含む欧米のデータをどのように邦人女性に適用するのか?-"Progress in Medicine. 18(1). 39-42 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "目で見る多嚢性卵巣症候群の診断と治療"HORMONE FRONTIER IN GYNECOLOGY. 5(1). 2-5 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 関守利: "ARTにおける難治症例のスクリーニングと治療法"産婦人科の実際. 48巻 2号. 333-342 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 安部由美子: "インヒビリン、アクチビン、フォリスタチン"生殖内分泌文科会NEWSLETTER. N0.3. 12-13 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高取修: "直説法による血中エストロン測定法の検討"核医学技術. Vol,18. No,1:3-8 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 伊吹令人: "最適排卵法の確立"厚生省心身障害者研究 不妊治療の在り方に関する研究. 144-160 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshimura. S: "Stage-specific distributions of inhibin a-subunit in bovine ovarian ffollicles and and various hormone levels in follicular fluid"J. Reprod. Develop. 45. 213-222 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yada. H: "Role of ovarian theca and granulosa cell interaction in hormone production and cell growth during the bovine follicular maturation process"Biol. Reprod. 61. 1480-1486 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "閉経期 「最新骨粗鬆症」 (折茂 肇編)"ライフサイエンス出版,東京. 4 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mizunuma,H: "Frontiers in Endocrinology Vol.21 Ovarian Function Research"Serono Symposia Publications. 7 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 安藤一道: "流・早産、子宮外妊娠 新女性医学大系15不妊・不育(武谷勇二編)"中山書店,東京. 12 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水沼英樹: "エストロゲン プラクティカル内科シリーズ4骨粗鬆症(松本俊夫編)"南江堂,東京. 4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 安部由美子: "新女性医学大系12排卵と月経 武谷勇二総編集、青野敏博、麻生武志、中野仁雄、野澤志朗編集、岡村均担当編集 インヒビン、アクチビン、フォリスタチン"中山書店(東京). 18 (1998)

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  • [Publications] Hasegawa.Y: "Proceeding of International Workshop on Embryogenetsis and Implantation"Inhibins,activins and follistatins; Novel regulators for the follicle development and oocyte growth (in press). (2000)

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  • [Publications] 安部由美子: "産婦人科の世界 第50巻 冬季増刊号 卵巣-機能と病態生理- インヒビン、アクチビン、フォリスタチン"医学の世界社. 68-76 (1998)

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  • [Publications] 安部 由美子 他: "インヒビン,アクチビン,フォリスタチン" 生殖内分泌分科会 NEWSLETTER. No.3. 12-13 (1998)

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  • [Publications] 安部 由美子 他: "妊娠とアクチビン,インヒビン" Hormone Frontier in Gynecology. 5・1. 63-71 (1998)

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  • [Publications] 高取 修 他: "直接法による血中エストロン測定法の検討" 核医学技術. 18・1. 3-8 (1998)

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  • [Publications] Andoh-K et al: "A comparative study of fixed-dose,step-down,and low-dose step-up regimens of human menopausal gonadotropin for patients with polycystic ovary syndrome." Fertil-Steril. Nov;70(5). 840-846 (1998)

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  • [Publications] Iizuka-M et al: "Chemical assay of iron in ovarian cysts:a new diagnostic method to evaluate endometriotic cysts." Gynecol-Obstet-Invest.46(1). 58-60 (1998)

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  • [Publications] Liu-X et al: "Effects of growth hormone,activin,and fallistatin on the development of preantral follicle from immature female mice." Endocrinology. May;139(5). 2342-2347 (1998)

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  • [Publications] 安部 由美子 他: "インヒビン、アクチビン、フォリスタチン(新女性医学大系 12 排卵と月経)" 武谷雄二総編集 岡村均担当編集 中山書店(東京), 401(p.107-124) (1998)

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  • [Publications] 安部 由美子 他: "インヒビン,アクチビン,フォリスタチン(産婦人科の世界 第50巻冬季増刊号 卵巣-機能と病態生理)" 吉村泰典編集企画 飯塚理八他編集 医学の世界社, 68-76 (1998)

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Published: 1998-04-01   Modified: 2016-04-21  

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