Study on ability of Maxillo-facial growth in the patients with congenital anomalies by HLA-typing

• Project/Area Number: 10557195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 展開研究
• Research Field: 矯正・小児・社会系歯学
• Research Institution: University of Tokyo
• Principal Investigator: SUSAMI Takafumi University of Tokyo, Faculty of Medicine, Department of Oral and Maxillo-facial surgery, Dentistry and Orthodontics, Associate Professor, 医学部・附属病院, 助教授 (80179184)
• Co-Investigator(Kenkyū-buntansha): TUKUNAGA Katushi University of Tokyo, Faculty of Medicine, Professor, 大学院・医学系研究科, 教授 (40163977) ; TAKATO Tuyoshi University of Tokyo, Faculty of Medicine, Professor, 医学部・附属病院, 教授 (90171454)
• Project Period (FY): 1998 – 1999
• Project Status: Completed (Fiscal Year 1999)
• Budget Amount: ¥9,800,000 (Direct Cost: ¥9,800,000); Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 1998: ¥6,800,000 (Direct Cost: ¥6,800,000)
• Keywords: CL (Cleft Lip) / CLP (Cleft Lip and Palate) / HLA-B / HLA-DRB1 / Japanese / HLA-DRBI / 口唇・口蓋裂 / HLA / 遺伝子多型解析

Research Abstract

Nucleotide sequence level typing of HLA-B, -DRB1, and -DPB1 alleles was performed on Japanese patients with cleft lip with or without cleft palate (CL/P). Two HLA-B alleles, B*1501 and B*5101, showed a significant positive association with CL/P. The increase of B*1501 was evident in female patients (OR = 3.6, pc = 0.005), whereas the increase of B*5101 was evident in male patients (OR = 3.7, pc < 0.002). One HLA-DRB1 allele, HLA-DRB1*0802 also showed an increase in CL/P patients. Conversely, HLA-B*4403 End DRBl*1302 were not observed in the patient group (pc = 0.004 and pc = 0.007, respectively). No HLA-DPB1 alleles showed significant association with CL/P. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of CL/P.

Research Products

• [Publications] Y. Sakata, et al.: "Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Y. Sakata, K. Tokunaga et al.: "Significant association of HLA-B and HIA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Y.Sakata,et al.: "Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate"Tissue Antigens. 53. 147-152 (1999)
• [Publications] 坂田康彰、高戸 毅: "口唇口蓋裂の疫学的研究(13章 HLAによる解析)"東山書房. 204 (1998)
• [Publications] Y.SAKATA: "Significant association of HLA-B and HLA-DRB1 alleles with CL/P" Tissue Antigens. 53(2). 147-152 (1999)
• [Publications] 坂田康彰: "口唇口蓋裂の疫学的研究(第13章 HLAによる解析)" 東山書房, 7 (1998)