| Project/Area Number |
10557195
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | University of Tokyo |
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Principal Investigator |
SUSAMI Takafumi University of Tokyo, Faculty of Medicine, Department of Oral and Maxillo-facial surgery, Dentistry and Orthodontics, Associate Professor, 医学部・附属病院, 助教授 (80179184)
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| Co-Investigator(Kenkyū-buntansha) |
TUKUNAGA Katushi University of Tokyo, Faculty of Medicine, Professor, 大学院・医学系研究科, 教授 (40163977)
TAKATO Tuyoshi University of Tokyo, Faculty of Medicine, Professor, 医学部・附属病院, 教授 (90171454)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥6,800,000 (Direct Cost: ¥6,800,000)
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| Keywords | CL (Cleft Lip) / CLP (Cleft Lip and Palate) / HLA-B / HLA-DRB1 / Japanese / HLA-DRBI / 口唇・口蓋裂 / HLA / 遺伝子多型解析 |
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| Research Abstract |
Nucleotide sequence level typing of HLA-B, -DRB1, and -DPB1 alleles was performed on Japanese patients with cleft lip with or without cleft palate (CL/P). Two HLA-B alleles, B*1501 and B*5101, showed a significant positive association with CL/P. The increase of B*1501 was evident in female patients (OR = 3.6, pc = 0.005), whereas the increase of B*5101 was evident in male patients (OR = 3.7, pc < 0.002). One HLA-DRB1 allele, HLA-DRB1*0802 also showed an increase in CL/P patients. Conversely, HLA-B*4403 End DRBl*1302 were not observed in the patient group (pc = 0.004 and pc = 0.007, respectively). No HLA-DPB1 alleles showed significant association with CL/P. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of CL/P.
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