| Project/Area Number |
10558002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
体育学
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| Research Institution | MIE UNIVERSITY |
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Principal Investigator |
TOGASHI Kenji MIE UNIVERSITY, FACULTY OF EDUCATION, ASSOCIATE PROFESSOR, 教育学部, 助教授 (10227564)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Hidenari NATIONAL MIE HOSPITAL, PEDIATRICAN, MD, 小児科, 厚生技官
SOYA Hideaki UNIVERSITY OF TSUKUBA, INST. OF HEALTH AND SPORTS SCIENCES, ASSOCIATE PROFESSOR, 体育科学系, 助教授 (50221346)
WAKITA Hirohisa MIE UNIVERSITY, FACULTY OF EDUCATION, PROFESSOR, 教育学部, 教授 (10024473)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | OBESE CHILDREN / EXERCISE TREATMENT / DIET TREATMENT / LEPTIN / ENERGY METABOLISM / BODY FAT DISTRIBUTION |
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| Research Abstract |
The study investigated the influence of a weight reduction program for obese children based on a combination of diet and exercise on energy metabolism, blood leptin level and body fat distribution. The subjects consisted of severe obese children. Physique, body composition and energy metabolism were measured, and computed tomography, blood sampling and graded exercise test were performed before and after a 19-week weight reduction program. The weight reduction program included diet treatment and exercise treatment designed in accordance with the individual pathologic conditions and physical fitness level. At the end of the weight reduction program, body weight was significantly reduced, while LBM tended to increase, and fat was selectively decreased. The risk factors for chronic disease were improved, and the blood leptin level was also reduced. However, the leptin/total fat area ratio was significantly decreased after the weight reduction program, indicating improvement in leptin resistance. Subcutaneous fat and visceral fat measured on computed tomographic scans were significantly diminished, but there was no difference in energy metabolism or blood leptin level due to differences in regions where fat had accumulated. The absolute value of basic metabolism was significantly decreased, but the amount per body weight was significantly increased, demonstrating an increase in energy expenditure. There was no significant change in DIT after the weight reduction program. These results suggest that an appropriate weight reduction program reduces risk factors for chronic disease, improving leptin resistance, thereby increasing energy expenditure such as basic metabolism. Therefore, such a program is suggested to be useful for preventing future chronic disease in obese children.
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