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Development of novel photoreaction-driven percutaneous devices in cardiovascular field

Research Project

Project/Area Number 10558143
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

NAKAYAMA Yasuhide  Dept. of Bioengineering, National Cardiovascular Center Research Institute, Group Head, 生体工学部, 室長 (50250262)

Co-Investigator(Kenkyū-buntansha) UEDA Hatsue  Dept. of Pathology, National Cardiovascular Center Research Institute, Group Head, 病理部, 医長
NAKAYAMA Atsuyoshi  Osaka National institute, Dept. of Organic Materials, Researcher, 有機機能材料部, 研究員
OYA Shoji  Dept. of Bioengineering, National Cardiovascular Center Research Institute, Researcher, 生体工学部, 室員 (80311447)
NISHI Shogo  Kitano Hospital, Dept of Neurosurgery, Vice Department Head, 脳外科, 副部長 (30312226)
松田 武久  九州大学, 大学院・医学系研究科, 教授 (60142189)
小橋 帝生  国立循環器病センター研究所, 生体工学部, レジデント 研究員
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥4,300,000 (Direct Cost: ¥4,300,000)
Keywordsphotoreaction / percutaneous treatment / stent / adhesive glue / Embolic material / Surface Design / Cardiovascular Disease / Drug Delivery / 経皮デバイス / 医用接着剤 / 塞栓材料 / 細胞 / 組織工学 / 組織
Research Abstract

The development of the devices and techniques for percutaneous treatment as a low invasion therapy in cardiovascular field are important especially in societies with many elderly people. Among them we have developed are as follows ; 1) visible light-induced tissue adhesive glue where styrenated gelatin and/or albumin-containing aqueous solutions with camphorquinone were gelated upon a few minutes of visible light irradiation, 2) embolic material for cerebral arteriovenous malformations and for local delivery of cytokines, 3) a novel high functional covered stent with micropore and drug delivery performance and hydrogel-coated stents both for prevention of restenosis and additionally a gene delivery device, and 4) the high performance balloon catheters with three functions of dilation of blood vessels, blood circulation and local delivery of drugs, all of which were driven by photochemistry. In addition, our efforts are also directed to application of gene therapy devices. We are pioneers in the development of these technologies and these techniques that will become the central in treatment of cardiovascular diseases.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (67 results)

All Other

All Publications (67 results)

  • [Publications] Y.Nakayama: "Surface Hydrogelation of Thiolated Water-Soluble Copolymers on Gold"Langmuir. 14. 3909-3915 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nishi: "Basic Fibroblast Growth Factor Impregnated Hydrogel Microspheres for Embolization of Cerebral Arteriovenous Malformations"ASAIO Journal. 44. M405-M410 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface Hydrogelation Using Photolysis of Dithiocarbamate or Xanthate : Hydrogelation,Surface Fixation,and Bioactive Substance immobilization"Langmuir. 15. 1667-1672 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "High-Spatioresolved Microarchifectural Surface Prepared by Photograft Copolymerization Using Dithiocarbamate : Surface Preparation and Cellular Responses"Langmuir. 15. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y,Nakayama: "Surface Macromolecular Microarchifecture Design : Biocompatible Surfacesvia Photo-Block-Graft-Copolymerization Using N,N-Diethyldithio carbamate"Langmuir. 15. 5560-5566 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Insitu Observation of Dithiocarbamate-Based Surface Photo graft Copolymerization Using Quartz Crystal Microbalance"Macromelecules. 32. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Heung Jae Lee: "Spatio-Resolved,Macromolecular Architectural Surface : Highly Branched Graft Polymer via Photo chemically Driven Quasiliving Polymerization Technique"Macromolecules. 32. 6989-6995 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Preparation of poly(ethylene glycol)-polystyrene block copolymers using photochemistry of dithiocarbamate as a reduced cell-adhesive coating materials"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kristin M.DeFife: "Spatial regulation and surface chemistry control of monocyte/macrophage adhesion and foreign body giant cell tormation by photochemically micropattemed surfaces"J.Biomed.Mater.Res. 45. 148-154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Photocurable Surgical Tissue Adhesive Glues Composed of Photoreactive Gelatin and Poly(ethylene glycol) Diacrylate"J.Biomed Mater.Res. 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "レーザー光微細加工技術と医療デバイス"日本レーザー医学会誌. 20. 333-344 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "人工臓器・組織工学における人工骨格設計(Scaffold Design):血管壁再構築モデルを用いた組織侵入過程のin vivo解析"人工臓器. 28. 528-532 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "光硬化型親水性高分子を用いたハイドロゲルマイクロビーズの作製:薬物包埋と細胞封入"人工臓器. 28. 250-255 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "人工臓器・組織工学の力学的人工骨格設計:弾性フィルムのエキシマレーザー加工による多孔構造化と力学的物性"人工臓器. 28. 237-241 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "組織工学・創傷治癒材料の生分解性設計:両末端エステル化ポリエチレングリコールアクロマーの合成,光ゲル化とゲルの生分解性"人工臓器. 28. 205-210 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "先端医療を支える高分子材料"高分子. 49. 113-116 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 西正吾: "高機能カバーステントの開発:微細加工化と薬物徐放機能"人工臓器. 29. 257-263 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中山泰秀: "可視光を用いたデバイスの新しい表面修飾技術の開発"人工臓器. 29. 197-202 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 大屋章二: "組織工学における人工細胞外マトリックス設計:感温性ヒアルロン酸の合成と構造化"人工臓器. 29. 446-451 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface microarchifectural design in biomedical applications : In vivo analysis of tissue in growth in excimer laser-divected micropored scaffold for cardiovascular tissue engineering"J.Biomed.Mater.Res. 51. 520-528 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Laboratory-Scale Mass Production of a Multi-Micropatterned Grafted Surface with Different Polymer Regions"J.Biomed.Mater.Res. 53. 584-591 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Kidoaki: "Measuring the Interaction Forces Between Proteins and Initerter-Based-Graft-Polymerized surfaces with An Atomic Force Microscope In Aqueous Media"Langmuir. 17. 1080-1087 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Kidoaki: "Thermoresponsive structural change of a poly(N-isopropylacrylamide)graft layer measured with an atomic force microscope"Langmuir. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sonoda: "Small-diameter compliant arterial graft prosthesis : Design concept of coaxial double-tubular graft and its fabrication"J.Biomed.Mater.Res.. 55. 266-276 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface hydrogelation of thiolated water-soluble copolymers on gold"Langmuir. 14. 3909-3915 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nishi: "Basic fibroblast growth factor impregnated hydrogel microspheres for embolization of cerebral arteriovenous malformations"ASAIO J.. 44. M405-M410 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface hydrogelation using photolysis of dithiocarbamate or xanthate : hydrogelation, surface fixation, and bioactive substance immobilization"Langmuir. 15. 1667-1672 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "High-spatioresolved microarchitectural surface prepared by photograft copolymerization using dithiocarbamate : surface preparation and cellular responses"Langmuir. 15. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface macromolecular microarchitectural design : biocompatible surfaces via photo-block-graft-copolymerization using N,N-diethyldithiocarbamate"Langmuir. 15. 5560-5566 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "In situ observation of dithiocarbamate-based surface photograft copolymerization using quartz crystal microbalance"Macromolecukes. 32. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Lee HJ: "Spatio-resolved, macromolecular architectural surface : highly branched graft polymer via photochemically driven quasiliving polymerization technique"Macromolecules. 32. 6989-6995 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Preparation of poly8ethylene glycol9-polystyrene block copolymers using photochemistry of dithiocarbamate as a reduced cell-adhesive coating materials"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] DeFife KM: " Spatio regulation and surface chemistry control of monocyte/macrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces"J Biomed Mater Res. 45. 148-154 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Photocurable surgical tissue adhesive glues composed of photoreactive gelatin and poly(ethyele glycol) diacrylate"J Biomed Mater Res. 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Laser microprocessing technology and its application for development of medical devices"JJSLSM. 20. 333-344 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Scaffold design in tissue engineering : in vivo analysis of the tissue ingrowth process using a vascular reconstruction model"Jpn J Artif Organs. 28. 528-532 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Preparation of hydrogel microbeads using photocurable hydrophilic polymers : drug immobilization and cell entrapment"Jpn J Artif Organs. 28. 250-255 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Structural design for arterial organs and tissue engineering : microporing of elastic films by excimer laser ablation and evaluation of the mechanical properties"Jpn J Artif Organs. 28. 237-241 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Bodegradable design for tissue engineering and wound healing materials : preparation of PEG ester macromers"Jpn J Artif Organs. 28. 205-210 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Polymeric materials for advanced medical technology"Kobunshi. 49. 113-116 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nishi: "Development of a novel highfunctional cavered stent with micropore and drug delivery performance"Jpn J Artif Organs. 29. 257-263 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Nishi: "Development of a novel high functional cavered stent with micropore and drug delivery performanceJpn J Artif Organs"Jpn J Artif Organs. 29. 257-263 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Development of a novel visible light-induced surface modification method for fabricated devices"Jpn J Anif Organs. 29. 197-202 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Ohya: "Artificial extracellular matrix design in tissue engineering : synthesis of thermoresponsive hyaluronic acid and its supramolecular organization"Jpn J Artif Organs. 29. 446-451 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Surface microoarchitectural design in biomedical applications : in vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering"J Biomed Mater Res.. 51. 520-528 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Nakayama: "Laboratory-scale mass production of a multi-micropatterned grafted surface with different polymer regions"J Biomed Mater Res. 53. 584-591 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Kidoaki: "Measuring the interaction forces between proteins and iniferter-based-graft-polymerized surfaces with an atomic force microscope in aqueous media"Langmuir. 17. 1680-1687 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] S.Kidoaki: "Thermoresponsive structural change of a poly(N-isopropylacrylamide) graft layer measured with an atomic force microscope"Langmuir. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Sonoda: "Small-diameter compliant arterial graft prosthesis : design concept of coaxial double-tubular graft and its fabrication"J Biomed Mater Res. 55. 266-276 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 西正吾: "高機能カバードステントの開発:微細加工化と薬物徐放機能"人工臓器. 29・1. 257-263 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中山泰秀: "可視光を用いたデバイスの新しい表面修飾技術の開発"人工臓器. 29・1. 197-202 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大屋章二: "組織工学における人工細胞外マトリックス設計:感温性ヒアルロン酸の合成と構造化"人工臓器. 29・2. 446-451 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Nakayama: "Surface microarchitectural design in biomedical applications : In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering"J.Biomed.Mater.Res.. 51. 520-528 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Nakayama: "Laboratory-scale mass production of a muti-micropatterned grafted surface with different polymer regions"J.Biomed.Mater.Res. 53. 584-591 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Nakayama: "Visible light-induced novel surface modification technique for fabricated devices"Trans of MRS Japan. 25・4. 923-926 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y. Nakayama: "Surface Hydrogelation Using Photolysis of Dithiocarbamate or Xanthate : Hydrogelation, Surface Fixation, and Bioactive Substance Immobilization"Laugmuir. 15・5. 1667-1672 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama: "Surface Macromolecular Microarchitecture Design : Biocompatible Surfaces vla Photo-Black-Graft-Copolymerization Using N.N-Diethyldithiocarbamate"Langmuir. 15・17. 5560-5566 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama: "lu situ Observation of Dithiocarbamate-Based Surface Photograft Copolymerization Using Quartz Crystal Microbalance"Macromolecules. 32・16. 5405-5410 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama: "Photocurable Surgical Tissue Adhesive Glue Composed of Photoreactive Gelatin and Poly(ethylene glycol) Diacrylate"J. Biomed. Mater. Res. (Appl. Biomater). 48. 511-521 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama: "Preparation of Pdy (ethylene glycol) polystyrene block copolymers cosing photochemistry of dithiocarbamate as a reduced cell-adhesive coating material"Biomaterials. 20. 963-970 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中山泰秀: "レーザー光微細加工技術と医療デバイス"日本レーザー医学会誌. 20・4. 333-344 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Nakayama: "Photocuvable Surgical Tissue Adhesive Glues Composed of Photoreactive Gelatin and Poly (ethylene glycol) Diacrylate" J.Biomed.Mater.Res.(1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中山 泰秀: "組織工学・創傷治癒材料の生分解設計:両末端エステル化ポリエチレングリコールエステルマクロマーの合成、光ゲル化とゲルの生分解性" 人工臓器. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中山 泰秀: "人工臓器・組織工学における人工骨格設計(Scaffold Design):血管壁再構築モデルを用いた組織侵入過程のin vivo解析" 人工臓器. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中山 泰秀: "人工臓器・組織工学の力学的人工骨格設計:弾性フィルムのエキシマレーザー加工による多孔構造化と力学的物性" 人工臓器. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 西 正吾: "bFGF-impregrated Hydrogel Microspheves for Embolization of (evebral Arfeviovenous Malfovmation (AUM)" ASAIO J.44. M405-M410 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中山 泰秀: "光硬化型親水性高分子を用したハイドロゲルマイクロビーズの作製:薬物包埋と細胞もれ" 人工臓器. (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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