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Network of Endocrine Disruptor Research in Japan

Research Project

Project/Area Number 10600001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionYokohama City University

Principal Investigator

IGUCHI Taisen  Yokohama City Univ., Professor, 理学部, 教授 (90128588)

Co-Investigator(Kenkyū-buntansha) NAGAYAMA Junya  Kyushu University, Associate Prof., 医療短期大学部, 助教授 (90136466)
NAGANUMA Akira  Tohoku University, Professor, 薬学部, 教授 (80155952)
HARA Akihiko  Hokkaido Unviersity, Professor, 水産学部, 教授 (40091483)
TANABE Shinsuke  Ehime University, Professor, 農学部, 教授 (60116952)
UMESONO Kazuhiko  Kyoto University, Professor, ウイルス研究所, 教授 (50183752)
Project Period (FY) 1998
Project Status Completed (Fiscal Year 1998)
KeywordsEndocrine distuptors / Environmental hormones / Reproductive abnormalities / Developmental abnormalities / Wildlife / Sewage treatment / 内分泌攪乱化学物質
Research Abstract

Numerous chemicals, pesticides, materials for plastics and detergents having estrogenic activity, have been released into the environment. These chemicals have potential to disrupt the development and function of the endocrine system in wildlife and humans, being called as endocrine disruptors (EDs). There is a hypothesis that EDs may related to decrease in population of wildlife, increase in breast cancer, endometriosis, testicular cancer and decrease in sperm count in humans, since these chemicals may bind to estrogen receptors and thus evoke estrogenic effects in animals and humans. We need to know the levels of EDs in the environment and potential effects on wildlife and humans. The present research was aimed at making a research group studying EDs in various aspects and recruit researchers from various research fields to share common interests. We organized public symposium on EDs in Yokohama. In zoology, Iguchi, Mori and Wada made a research groups to study effects of EDs on development and reproduction on animals. In fisheries, Hara made a research group to study usefulness of vitellogenin in monitoring of fish in river and sea. In pharmacology, Naganuma made a group to study the ecological effect of persistent pollutants. In agriculture and environmental science, Tanabe and Manabe made a group to study EDs effects on marine mammals and malformations. In medicine, Mori and Nagayama made a group to study EDs effects on fetus and human reproduction. Umesono and Sato studied made a group to study action mechanism of EDs. In technology, Matsui made group to study sewage treatment. Each research group is unique and these research groups work hard to solve endocrine disruptor issue and suggest how to control chemical release in the environment and reduce adverse effects on wildlife and humans by EDs.

Report

(2 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • Research Products

    (76 results)

All Other

All Publications (76 results)

  • [Publications] 井口泰泉: "1. 環境ホルモンの野生動物にたいする影響." 環境毒性学会誌. 1. 2-13 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 井口泰泉: "2. 環境ホルモン問題にどう挑むか." 科学. 68. 529-538 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 井口泰泉: "3. 環境ホルモン問題を整理する〜ゴードン会議にみる世界の動向〜." 現代化学. 10月号. 24-31 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤友美: "4. 内分泌撹乱化学物質のエストロゲン活性." ホルモンと臨床. 46. 571-578 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤友美: "5. 環境汚染と生殖." 日本産科婦人科学会誌. 50. 701-712 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤友美: "6. Mode of cell death in the rat metrial gland during peripartum regression." Anatomical Record. 252. 369-377 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 佐藤友美: "7. Apoptotic cell death in artificially induced deciduoma of pseudopregnant mice." Anatomical Record. 254. 205-213 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 守隆夫: "8. Effects of prenatal exposure to diethylstilbestrol on the sympathetic nervous system in the rat ovary." Neuroscience Letters. 255. 123-126 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 梅園和彦: "9. 核内受容体の構造分類と内分泌情報の統合." 日本臨床. 56. 1693-1698 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 梅園和彦: "10. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites." Genes and Development. 12. 1269-1277 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 原彰彦: "11. 魚の血液で環境ホルモン汚染をみる." 科学. 68. 591-596 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 和田勝: "12. Changes in circulating LH, sex steroid hormones, thyroid hormones and corticosterone in relation to breeding and molting in captive Humboldt Penguins (Spheniscus humoboldti) kept in an out door open display." Zoological Science. 15. 103-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田辺信介: "13. 海棲哺乳類を脅かす化学物質汚染." 科学. 68. 539-545 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田辺信介: "14. ブチルスズ化合物による海棲哺乳動物の汚染." 環境毒性学会誌. 1. 14-25 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田辺信介: "15. Butyltin contamination in marine mammals from North Pacific and Asian coastal waters." Environmental Science and Technology. 32. 193-198 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田辺信介: "16. Persistent organochlorine contaminants in ringed seals (Phoca hispida) from the Kara Sea, Russian Arctic." Environmental Toxicology and Chemistry. 17. 1745-1755 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 森千里: "17. 内分泌撹乱物質(環境ホルモン)の妊孕性に及ぼす影響." 産科と婦人科. 65. 860-868 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taisen Iguchi: "Effect of endocrine disruptors on wildlife. (in Japanese)" Ecotoxicology. 1. 2-13 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taisen Iguchi: "Approach to endocrine disruptor issue. (in Japanese)" Kagaku. 68. 529-538 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taisen Iguchi: "Reprot of Gordon Research Conference. (in Japanese)" Gendaikagaku, October. 24-31 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomomi Sato: "Estrogenic activity of endocrine disruptors. (in Japanese)" Horumon to Rinsyo. 46. 571-578 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomomi Sato: "Pollution of environment and reproduction. (in Japanese)" Nihonsanfujinkagakkaisi. 50. 701-712 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomomi Sato: "Mode of cell death in the rat metrial gland during peripartum regression." Anatomical Record. 252. 369-377 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomomi Sato: "Apoptotic cell death in artificially induced deciduoma of pseudopregnant mice." Anatomical Record. 254. 205-213 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takao Mori: "Effects of prenatal exposure to diethylstilbestrol on the sympathetic nervous system in the rat ovary." Neuroscience Letters. 255. 123-126 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kazuhiko Umesono: "Integration of nuclear receoptor structure and endocrine information. (in Japanese)" Nohonrinsho. 56. 1693-1698 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kazuhiko Umesono: "BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites." Genes and Development. 12. 1269-1277 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akihiko Hara: "Monitoring of endocrine disrutprs using fish serum. (in Japanese)" Kagaku. 68. 591-596 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaru Wada: "Changes in circulating LH, sex steroid hormones, thyroid hormones and corticosterone in relation to breeding and molting in captive Humboldt Penguins (Spheniscus humboldti) kept in an out door open display." Zoological Science. 15. 103-109 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shisuke Tanabe: "Chemical pollutants effect on marine mammals." Kagaku. 68. 539-545 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shisuke Tanabe: "Marine mammals polluted by oranotin compoounds. (in Japanese)" Ecoeoxicology. 1. 14-25 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shisuke Tanabe: "Butyltin contamination in marine mammals from North Pacific and Asian coastal waters." Environmental Science and Technology. 32. 193-198 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shisuke Tanabe: "Persistent organochlorine contaminants in ringed seals (Phoca hispida) from the Kara Sea, Russian Arctic." Environmental Toxicology and Chemistry. 17. 1745-1755 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chisato Mori: "Effect of endocrine distuptors on fertility. (in Japanese)" Sannka to Fujinka. 65. 860-868 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taisen Iguchi: "Morphogenic activity of tibroblast growth factor-2 on Primary neural Drocursor in three-dimensional culture" Pevelop.Growth Differ. 40. 59-65 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taisen Iguchi: "Development and application of an effective detection method for fish plasma vitellogenin induced by envivonmental" Biosci.Biotechnol.Biochem.62. 1196-1200 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taisen Iguchi: "Monoclonal antibody 14F7,wnich recognizes a Stage-specific immature oligodendrocvte surface molecule," J.Neurosci.Res.54. 79-96 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taisen Iguchi: "Mode of cell death in the rat metrialgland during perioartum regression" Anat,Rec.252. 369-377 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taisen Iguchi: "Apoptotic cell death in artificially induced decideoma of Dseudopregnant mice" Anat,Rec.254. 205-213 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taisen Iguchi: "Effects of steroid hormanes and growth factors on the development of the male mouse reprodutive trac in vitro" Zool.Sci.16. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン(外因性内分泌攪乱化学物質)の環境性物に対する影響" 安全工学. 37. 80-86 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモンの野生動物に対する影響" 環境毒性学会誌. 1. 2-13 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境汚染物質の内分泌毒性-内分泌攪乱化学物質の生殖攪乱作用-" 組織培養工学. 24. 264-267 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱物質のエストロゲン活性" ホルモンと臨床. 46. 571-578 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン" メディカル・テクノロジー. 26. 964-965 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "多摩川にみる魚類の異変" 科学. 68. 515-517 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン問題にどう挑むか-アメリカにみる研究と対策の最先端" 科学. 68. 529-238 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモンの魚類への影響-海外の報告" 科学. 68. 597 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "PCプラスチックから溶出するビスフェノールA" 化学. 53(7). 35-37 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境汚染と生殖" 日本産科婦人科学会誌. 50. 701-712 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "悪性度の異なる可移植性マウス乳腺腫瘍におけるメタロチオネイン発現に" 乳癌基礎研究. 7. 69-73 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン(内分泌攪乱物質)の野生動物への影響" Nippon Suisan Gakkaishi. 64. 899-900 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱化学物質とその問題点" 日本内分泌学会生殖内分泌分科会. 3. 6-7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱化学物質の何が問題か?" 遺伝. 52(11). 11-12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "外因性内分泌攪乱化学物質(環境ホルモン)" 日本臨床. 56. 2953-2962 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "外因性内分泌攪乱化学物質(環境ホルモン)について" 日本歯科医師会. 51. 15-24 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモンの生態系への影響と世界の対応" エコインダストリー. 4. 5-26 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "外因性内分泌攪乱化学物質environmental endocrine disruptors." Annual Review内分泌、代謝. 51-56 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン問題と分析化学" ぶんせき. 2. 156-160 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱化学物質(環境ホルモン)" 綜合臨床. 48. 37-39 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱化学物質(環境ホルモン)" 化学と教育. 47. 132-136 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "内分泌攪乱化学物質" 医学のあゆみ. 188. 789-792 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "エストロゲンと内分泌攪乱物質" 産科と婦人科. 66(2). 201-209 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "外因性内分泌攪乱化学物質問題に関する研究班中間報告書" 財団法人日本公衆衛生協会, 128 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン" 環境新聞社, 167 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン汚染の実態" 工業調査会, 9 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモンの何が問題か" 中央公論, 15 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "そんなに危険か環境ホルモン" 文芸春秋, 9 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "生殖異変" かもがわ出版, 111 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "よくわかる環境ホルモン学" 環境新聞社, 31 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン問題を整理する-ゴードン会議にみる世界の動向-" 現代化学, 8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモン人類の未来は守られるのか" 丸善ライブラリー, 191 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "環境ホルモンを考える" 岩波科学ライブラリー, 108 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "日本の論点'99" 文藝春秋, 4 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "くらしの豆知識'99" 国民生活センター, 2 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井口泰泉: "子どもを取り巻く環境ホルモン" 芽ばえ社, 6 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1999-12-08   Modified: 2016-04-21  

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