| Project/Area Number |
10640524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokushima University |
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Principal Investigator |
WADA Makoto Tokushima University, Faculty of Integrated Arts and Sciences, Professor, 総合科学部, 教授 (10016173)
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| Co-Investigator(Kenkyū-buntansha) |
徳島大学, 総合科学部, 教授
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Allylbismuth Reagent / Allyltin Reagent / Aqueous Media / water / Allylation Reaction / Asymmetric Allylation / c-c Bond Forming Reaction / Green Chemistry / 保護・脱保護 / カルボニル化合物 / 三塩化ビスマス / 金属ビスマス / 無保護糖 / 炭素-炭素結合生成 / ホモアリリックアルコール / アリルGrignard試薬 / ビスマス / スズ |
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| Research Abstract |
This summary presents the research results of a development of carbon-carbon bond forming reaction without protection of hydroxyl group and carboxyl group
(1) A Grignard-type additon of allyl unit to carbonyl compounds containing a carboxyl group by using bismuth trichloride-metallic zinc-allyl bromide.
(2) Allylation of aldehydes by using allylic alcohols in the presence of metallic bismuth
(3) A novel aqueous Barbier-Grignard-type allylation of aldehydes in a metallic magnesium/bismuth trichloride bimetal system.
(4) Allylation of carbonyl compounds by using allyl Grignard reagent and various metallic salts in aqueous media.
(5) Allylation of aldehydes by using allyltin compounds in aqueous media.
(6) Asymmetric allylation of carbonyl compounds by using tetraallyltin.
(7) Bismuth mediated allylation of unprotected carbohydrates.
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