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Research on Cross-Sectional Imaging of Elasticity around Atherosclerotic Plaque with Transcutaneous Ultrasound

Research Project

Project/Area Number 10650400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KANAI Hiroshi  Graduate School of Engineering, Tohoku University, Associate Professor, 大学院・工学研究科, 助教授 (10185895)

Co-Investigator(Kenkyū-buntansha) KOIWA Yoshiro  Graduate School of Engineering, Tohoku University, Associate Professor, 大学院・医学系研究科, 助教授 (80091685)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsatherosclerosis / medical ultrasonics / elasticity / phased tracking / noninvasive measurement / tissue characterization / atheroma / bio-rheology / 心筋症 / リアルタイム計測 / 心筋viability / 循環器系定量診断
Research Abstract

The phased tracking method is unique in its extremely higher spatial and temporal resolution. This report shows the cross sectional image of the elasticity around the atherosclerotic plaque with this phase tracking method using transcutaneous ultrasound.
The minimum value of the measurable velocity is 0.5 mm/s and the time interval, ΔT, of integration is 222 μs. In this condition, the lowest value of the change in thickness is found to be about 0.1μm in the measurements using a water tank. Such a minute change in thickness cannot be measured by CT, MRI, or standard ultrasonic diagnostic equipment.
By presetting multiple points with equal intervals of 375 μm in the arterial wall at the R-wave of the ECG, and applying the above method to each point, the change in thickness in each layer between the succeeding points is determined. The change in thickness of each layer from that at the R-wave is then converted into color maps and displayed. By the proposed procedure described above, the elastic modulus E of the human carotid artery is noninvasively evaluated for the five layers along the ultrasonic beam.
By modifying the method and system described above so that the elastic modulus of each local point in the arterial wall and the atherosclerotic plaque is determined by controlling the position of the ultrasonic beam. The results are then converted into another color map representing local elasticity in the cross sectional image. The regional elasticity is measured at each point along the ultrasonic beams at 30 positions along the axial direction of the artery. The resolution in the depth direction and axial direction is 375 μm and 0.98 mm, respectively. The atherosclerotic plaque has been characterized as the compliant material interior surrounded by much elastic material. With extrapolation of the results in an in vitro study, we interpreted the surrounding thin layer as the fibrous cap of the plaque.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] 中屋,金井,中鉢,本田,小岩: "超音波で計測した心臓壁微小振動の解析による左室拡張末期圧と心筋弾性値の非侵襲計測"医用電子と生体工学. 37. 1-8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi Kanai,Yoshiro Koiwa: "PARCORR-Based Time-Dependent AR Spectrum Estimation of Heart Wall Vibrations"IEICE Trans, on Fundamentals of Electronics, Communications and Computer Sciences. E82-A. 572-579 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Kanai,他3名: "Noninvasive Estimation of Left-Ventricular End-Diastole Elasticity by Analyzing Heart Wall Vibrations"Electronics Letters. 35. 765-766 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Kanai,Y.Koiwa,他3名: "Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls"Japanese Journal of Applied Physics. 38. 3403-3408 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Kanai,Y.Koiwa,J.Zhang: "Real-Time Measurements of Local Myocardium Motion and Arterial Wall Thickening"IEEE Trans. on Ultrasonics, Ferroelectrics, and Frequency Control. 46. 1229-1241 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Kanai,他3名: "Accuracy Evaluation in Ultrasonic-based Measurement of Microscopic Change in Thick-ness"Electronics Letters. 35. 949-950 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 金井浩: "音・振動のスペクトル解析"コロナ社. 328 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigemitsu NAKAYA, Hiroshi KANAI, Noriyoshi CHUBACHI, Hideyuki HONDA, Yoshiro KOIWA: "Non-invasive measurement of Left Ventricular End-Diastolic Pressure and Myocardial Elasticity by Analysis of Small Vibration on Heart Wall"Japanese Journal of Medical Electronics and Biological Engineering. Vol. 37, No. 1. 1-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI, Yoshiro KOIWA: "PARCORR-Based Time-Dependent AR Spectrum Estimation of Heart Wall Vibrations"IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. Vol. E82-A, No. 4. 572-579 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI, Shigemitsu NAKAYA, Hideyuki HONDA, and Yoshiro KOIWA: "Noninvasive Estimation of Left-Ventricular End-Diastole Elasticity by Analyzing Heart Wall Vibrations"Electronics Letters. Vol. 35, No. 10. 765-766 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI, Yoshiro KOIWA, Yoshiko SAITO, Ikuko SUSUKIDA, and Motonao TANAKA: "In vivo Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls"Japanese Journal of Applied Physics. vol. 38, part 1, No. 5B. 3403-3408 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI, Yoshiro KOIWA, Jianping ZHANG: "Real-Time Measurements of Local Myocardium Motion and Arterial Wall Thickening"IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. vol. 46, No. 5. 1229-1241 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI, Kohshiro SUGIMURA, Yoshiro KOIWA, Yasuo TSUKAHARA: "Accuracy Evaluation in Ultrasonic-based Measurement of Microscopic Change in Thickness"Electronics Letters. 949-950 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi KANAI: "Spectrum Analysis of Sound and Vibration"Corona publishing Co., Ltd.. 1-328 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中屋,金井,中鉢,本田,小岩: "超音波で計測した心臓壁微小振動の解析による左室拡張末期圧と心筋弾性値の非侵襲的計測"医用電子と生体工学. 37. 1-8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Kanai,Yoshiro Koiwa: "PARCORR-Based Time-Dependent AR Spectrum Estimation of Heart Wall Vibrations"IEICE Trans. on Fundamentals of Electronics, Communications and Computer Sciences. E82-A. 572-579 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kanai 他3名: "Noninvasive Estimation of Left-Ventricular End-Diastole Elasticity by Analyzing Heart Wall Vibrations"Electronics Letters. 35. 765-766 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kanai,Y.Koiwa 他3名: "Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls"Japanese Journal of Applied Physics. 38. 3403-3408 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kanai,Y.Koiwa,J.Zhang: "Real-Time Measurements of Local Myocardium Motion and Arterial Wall Thickening"IEEE Trans. on Ultrasonics, Ferroelectrics, and Frequency Control. 46. 1229-1241 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kanai 他3名: "Accuracy Evaluation in Ultrasonic-based Measurement of Microscopic Change in Thickness"Electronics Letters. 35. 949-950 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 金井 浩: "音・振動のスペクトル解析"コロナ社. 328 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Takano, H.Kanai, N.Hoshimiya, N.Chubachi: "Dependent of Elastic Modulus on Inner Pressure of Tube Wall Estimated from Measured Pulse Wave Velocity" IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. E81-A・5. 889-894 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Hasegawa, H.Kanai, N.Hoshimiya, N.Chubachi, and Y.Koiwa: "Accuracy Evaluation in Measurement of a Small Change in the Thickness of Arterial Walls and the Measurement of Elasticity of the Human Carotid Artery" Japanese Journal of Applied Physics. 37・5B. 3101-3105 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 杉村公史郎,金井 浩,中鉢憲賢,塚原保夫,小岩喜郎,鎌田英一,手塚文明: "心筋の局所厚み変化の非侵襲的計測による心筋障害の評価" 超音波医学. 25・5. 625-631 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 長谷川英之,金井 浩,星宮 望,中鉢憲賢,小岩喜郎: "動脈壁の厚み変化波形の周波数解析" 日本音響学会誌. 54・7. 473-481 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Kanai, and Yoshiro Koiwa: "PARCORR-based Time-Dependent AR Spectrum Estimation of Heart Wall Vibrations" IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. E82-A・4(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Kanai, Y.Koiwa, Y.Saito, I.Susukida, and M.Tanaka: "In vivo Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls" Japanese Journal of Applied Physics. 38・5B(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 金井 浩: "『音・振動のスペクトル解析』" コロナ社, 328 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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