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Development of hybrid implant biomaterials by excimer laser irradiation and study on laser-tissue interaction mechanism

Research Project

Project/Area Number 10650722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Material processing/treatments
Research InstitutionKinki University

Principal Investigator

NAKAYAMA Takeyoshi  Kinki University, Dep. of Electrical Eng., Professor, 理工学部, 教授 (60023313)

Co-Investigator(Kenkyū-buntansha) NAKANO Hitoshi  Kinki University, Dep. of Electrical Eng., Lecturer, 理工学部, 講師 (20257968)
HASHISHIN Yuichi  Kinki University, Dep. of Electrical Eng., Lecturer, 理工学部, 講師 (90156266)
NAKATA Junichi  Kinki University, Dep. of Electrical Eng., Associate Professor, 理工学部, 助教授 (80122076)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsLaser ablation / Laser irradiation effect / Ceramics / Surface modification / Biocompatible materials / Alumina / Hydroxyapatite / Titanium / 疑似生体液
Research Abstract

The aims of this project are (1) Development of a biocompatible material which is implant in living human body by using excimer laser irradiation method and (2) Elucidation of laser light-tissue interaction mechanism.
The results obtained in this project are as follows ;
A. Development of biocompatible material
(1) Formation of hydroxyapatite (HAp) layer on AlィイD22ィエD2OィイD23ィエD2 substrate by excimer laser irradiation method was achieved.
(2) Formation of a new bone on the surface of the above-mentioned sample was observed when the sample was immersed in stimulated body fluid (SBF) for 2 weeks.
(3) A new laser irradiation method was developed for HAp coating on Ti.
B. Laser light-tissue interaction mechanism.
(1) The difference between KrF and ArF excimer laser irradiation effect for soft tissue was explained through the spectroscopic study.
(2) Mechanism of laser ablation for hard tissue was elucidated by time-resolved photography.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] T. MATSUTANI, K. KUMAZAKI, T. NAKAYAMA: "Development of a hard tissue substitution material by UV laser irradiation method"Proceeding of The First Asian Pacific Laser Symposium. Wc-4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. NAKANO, T. NAKAYAMA: "Mechanism associated with ArF and KrF Excimer laser ablation of human tooth enamel"Rev. Laser Eng.. 26Supple.. 37-41 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. NAKANO, D. AKITA, T. NAKAYAMA: "Changes in the chemical structure of lipids as a result of ultraviolet laser irradiation"日本レーザー医学会誌. 19. 191-195 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 桑田、熊崎、松谷、中山: "レーザー照射法により作成したHAp/Al_2O_3の疑似生体環境でのアパタイト形成メカニズム"近畿大学理工学部研究報告. 34号. 59-63 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松谷、熊崎 中山: "エキシマレーザー照射による生体親和性材料の開発"光・量子デバイス研究会資料. OQD-98-47. 13-17 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. KUMAZAKI, M. KUWATA, T. MATSUTANI, TNAKAYAMA: "Surface modification of biomaterials by laser irradiation method"Tech. Digest of CLEO/Pcific Rim'99. 4. 1301-1302 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 桑田、松谷、中山: "レーザー光を用いたセラミックス材料へのハイドロキシアパタイトコーティング法"レーザー学会第268回研究会報告. RTM-99-27. 7-12 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nakano, Y. Hosokawa, T. Nakayama and U. Kubo: "Mechanism associated with excimer laser ablation of tooth enamel (in Japanese)"Proc. 18ィイD1thィエD1 Conf of Jap. Soc. Laser Medicine. 18. 279 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nakano, T. Nakayama and U. Kubo: "Experimental study on ultraviolet laser ablation of lipid (in Japanese)"Rev. Laser Eng.. 26. 168 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nakano and T. Nakayama: "Mechanism associated with ArF and KrF excimer laser ablation of human tooth enamel"Proc. 1st Asian Pacific Laser Symposium Mb-2. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Matsutani, K. Kumazaki and T. Nakayama: "Development of a hard tissue substitution materials by UV laser irradiation method"Proc. 1st Asian Pacific Laser Symposium Wc-4. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nakano and T.Nakayama: "Mechanism associated with ArF and KrF excimer laser ablation of human tooth enamel"Rev. Laser Eng.. 26. 37 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nakano, D. Akita and T. Nakayama: "Change in the chemical structure of lipids as a result of ultraviolet laser irradiation"J. Jap. Soc. Laser Sur. Med.. 19. 191 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Kuwata, K. Kumazaki, T. Matsuani and T. Nakayama: "Growing mechanism of apatite in the simulated body environment of HAp/Al203 biomaterial formed by the laser irradiation method (in Japanese)"J. Faculty of Sci. and Tech. Kinki Univ.. 34. 59 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Matsutani, K. Kumazaki and T. Nakayama: "Development of biocompatible implant material by excimer laser irradiation method (in Japanese)"Proc.Photo-Quntum Device Symp.. OQD-98-47. 13 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Kumazaki, M. Kuwata, T. Matsutani and T. Nakayama: "Surface modification of biomaterials by laser irradiation method"Tech. Digest of CLEO/Pacific Rim '99. 4. 1301 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Kuwata, T. Matsutani and T. Nakayama: "Hydroxyapatite coating methods for ceramics by using laser light (in Japanese)"Report on the 268ィイD1thィエD1 Topical Meeting of the Laser Society of Japan. RTM-99-27. 7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.MATSUTANI,K.KUMAZAKI,T.NAKAYAMA: "Development of a hard tissue substitution material by UV laser irradiation method"Proceedings of The First Asian Pacific Laser Symposium,. Wc-4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.NAKANO,T.NAKAYAMA: "Mechanism Associated with ArF and KrF Excimer Laser Ablation of Human Tooth Enamel"Rev.Laser Eng.. 26巻Supple.. 37-41 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.NAKANO,D.AKITA T,NAKAYAMA: "Changes in the Chemical Structure of Lipids as a Resuit of Ultraviolet Laser Irradiation"日本レーザー医学会誌. 19巻4号. 191-195 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 桑田、熊崎、松谷、中山: "レーザー照射法により作成したHAp/Al_2O_3の疑似生体環境でのアパタイト形成メカニズム"近畿大学理工学部研究報告. 34号. 59-63 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松谷、熊崎、中山: "エキシマレーザー照射による生体親和性材料の開発"光・量子デバイス研究会資料. OQD-98-47. 13-17 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.KUMAZAKI,M.KUWATA,T.MATSUTANI,TNAKAYAMA: "Surface modification of biomaterials by laser irradiation method"Tech Digest of CLEO/Pacific Rim'99. 4巻. 1301-1302 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 桑田、松谷、中山: "レーザー光を用いたセラミックス材料へのハイドロキシアパタイトコーティング法"レーザー学会第268回研究会報告. RTM-99-27. 7-12 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.MATSUTANI,H.MATSUE,K.KUMAZAKI,U.KUBO,T.NAKAYAMA: "TiN film for Transparent Conductors Formed by Pulsed Laser Deposition in Reavtive Gas" Rev.Laser.Eng.26巻7号. 563-564 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.MATSUTANI,H.MATSUE,K.KUMAZAKI,T.NAKAYAMA: "Transparent Conductor Film Based on Titanium Nitride Formed by Reactive Pulsed Laser Deposition" Proceeding of The First Asian Pacific Laser Symposium. WI-1 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.MATSUTANI,K.KUMAZAKI,T.NAKAYAMA: "Development of a Hard Tissue Substitution Material by UV Laser Irradiation Method" Proceeding of The First Asian Pacific Laser Symposium. Wc-1 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.MATSUTANI,H.MATSUE,K.KUMAZAKI,T.NAKAYAMA: "Transparent Conductor Film Based on Titanium Nitride Formed by Reactive Pulsed Laser Deposition" Rev.Laser.Eng.26巻 Supple.14-18 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.NAKANO,D.AKITA,T.NAKAYAMA: "Changes in the Chemical Structure of Lipids as a Result of Ultraviolet Laser Irradiation" 日本レーザー医学会誌. 19巻4号. 191-195 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松谷,熊崎,中山: "エキシマレーザー照射による生体親和性材料の開発" 光・量子デバイス研究会資料. OQD-98-47. 13-17 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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