| Project/Area Number |
10660126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食品科学・栄養科学
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
IKEDA Ikuo Kyushu University, Agriculture, Associate Professor, 農学部, 助教授 (40136544)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | seal oil / fish oil / triacylglycerol / arachidonic acid / thromboxane / docosahexaenoic acid / apolipoprotein E / eicosapentaenoic acid / 構造脂質 / 脂肪酸合成酵素 / プロスタサイクリン |
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| Research Abstract |
Rats were given a diet containing seal oil in which EPA and DHA are mainly distributed at the sn-1 and 3 positions or fish oil in which they are mainly at the sn-2 position. The content of EPA and DHA was adjusted to the same between the diets containing seal and fish oils. Linoleic acid-rich oil was used as a control. Seal oil more effectively reduced the concentration of triacylglycerol in plasma and liver compared with fish oil. The reduction of triacylcglycerol was caused by the decreased fatty acid synthesis in the liver. The production of thromboxane AィイD22ィエD2 in platelet was effectively lowered in rats fed seal oil diet. The content of arachidonic acid in liver phosphatidylcholine and phosphatidylethanolamine was more effectively reduced by the feeding of seal oil than fish oil. The long time feeding of seal or fish oils in ExHC rats and apolipoprotein E deficient mice also showed that seal oil is more effective to reduce arachidonic acid content in tissue phospholipids. These observations suggested that EPA and DHA bound to sn-1,3 positions of triacylglycerol are more effective to prevent thrombosis and atherosclerosis than those bound to sn-2 position.
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