| Project/Area Number |
10660167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
林産学
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KAWACHI Shinsaku miyazaki Univ., Dep.of Agriculture, Professor., 農学部, 教授 (00040858)
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| Co-Investigator(Kenkyū-buntansha) |
MEGURO Sadatoshi miyazaki Univ., Dep.of Agriculture, Professor., 農学部, 教授 (50112321)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Anti-tumor / Basidiomycetes / Phellinus linteus / Host selection / Morus bombycis / Wood rotting fungi / Oxyresveratrol / Antifungal activity / オキシレスベラロール |
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| Research Abstract |
Yamaguwa is well known as one of the most durable wood for decay in Japan. Anti-tumor mushroom, meshimakobu is found typically in this yamaguwa wood. We attempted to clear the reason why mesimakobu selects yamaguwa as a host wood.
The mycerial growth of mesimakobu in yamaguwa wood was promoted more than kunugi and konara wood. In the case of mannentake, kawaratake and shiitake, their growth were depressed in yamaguwa wood. It was found that a hot water extracts of yamaguwa contained a promoter for meshimakobu and methanol extracts contained inhibitors for other wood rotting fungi.
The phenol fraction of methanol extracts of yamaguwa showed greater antifungal activities for wood rotting fungi, other than meshimakobu. Oxyresveratrol was presumed as a main antifungal factor in a phenol fraction of methanol extracts of yamaguwa. Meshimakobu was however very weak and easily defeated by other wood rotting fungi even when oxyresveratrol was added in a culture medium.
From these results, it seems that meshimakobu could be barely survived only in yamaguwa because antifungal factor, oxyresveratrol prevented significantly the growth of other strong wood rotting fungi.
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