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Effects of maternal chronic uremia on the development of fetal kidney : expression of growth factors and genes

Research Project

Project/Area Number 10660288
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionOsaka Prefecture University

Principal Investigator

OKADA Toshiya  Graduate School of Agriculture and Biological Science, Osaka Prefecture University Assistant Professor, 農学生命科学研究科, 講師 (00169111)

Co-Investigator(Kenkyū-buntansha) MUKAMOTO Masafumi  Graduate School of Agriculture and Biological Science, Osaka Prefecture University Assistant Professor, 農学生命科学研究科, 講師 (80231629)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsmaternal nephrectomy / fetal kidney / cell proliferation / apoptosis / growth factor / oncogene / tumor suppressor gene / apoptosis suppressor gene / p53 / WT1 / EGFR / 胎児腎臓 / insulin like growth factor1 / epidermal growth factor receptor / proliferating cell nuclear antigen / epidermal growth factor / vascular endothelial cell growth factor
Research Abstract

The present study designed to clarify the development of fetal kidney when maternal kidney become dysfunctional. During perinatal period, intense cell proliferation and apoptosis were present in the kidney. The number of proliferating cells was decreased with age at this period. Percentage of apoptotic cells in fetal kidney was significantly increased from fetal day 18 through 20 and decreased thereafter. Maternal uninephrectomy induced lowered proliferative activity of mature glomerulus, increased immunoreactivity of vascular endothelial growth factor (VEGF) of immature glomerulus and increased immunoreactivities of epidermal growth factor (EGF) and EGF receptor in proximal tubules in fetal kidney. Further, maternal uninephrectomy induced increased number of apoptotic cells of collecting ducts and decreased expressions of c-fos, bcl-2, p53 and WT 1 mRNA.These results indicate that the development of fetal kidney is accelerated by maternal uninephrectomy, that the lowered proliferative activity of mature glomerulus is due to the enhanced expression of VEGF in immature glomerulus and decreased expression of oncogene (c-fos), and that the increase of apoptosis in collecting ducts is due not to elevated expression of tumor suppressor gene but to decreased expression of apoptosis suppressor gene.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Okada,T.: "Effects of Maternal Uninephrectomy on the Development of Fetal Rat kidney with Special reference to the Proliferative Activity and Epidermal Growth Factor(EGF)"Congenital Anomalies. 40. 275-281 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okada,T.: "Perinatal Development of the Rat Kidney : Proliferative Activity and Epidermal growth Factor"Biology of the Neonate. 79. 46-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okada, T.et al.: "Effects of Maternal Uninephrectomy on the Development of Fetal Rat kidney with Special reference to the Proliferative Activity and Epidermal Growth Factor (EGF)"Congenital Anomalies. 40(4). 275-281 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okada, T.et al.: "Perinatal Development of the Rat Kidney : Proliferative Activity and Epidermal growth Factor"Biology of the Neonate. 79(1). 46-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okada,T.: "Effects of Maternal Uninephrectomy on the Development of Fetal Rat kidney with Special reference to the Proliferative Activity and Epidermal Growth Factor (EGF)"Congenital Anomalies. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Okada,T.: "Perinatal Development of the Rat Kidney : Proliferative Activity and Epidermal growth Factor"Biology of the Neonate. 79・1. 46-53 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岡田利也: "母体片側腎臓摘出時のラット胎子腎臓の発達:細胞増殖因子と遺伝子の発現"第130回日本獣医学会学術集会講演要旨集. 80 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岡田利也: "母体片側腎臓摘出時のラット胎子腎臓の発達:epidermal growth factor(EGF)およびvascular endothelial growth factor(VEGF)の関与"第39回日本先天異常学会学術集会抄録集. 144-144 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岡田利也: "母体片側腎臓摘出による胎子腎臓の発達に対する影響:細胞増殖因子の関与" 第127回日本獣医学会講演要旨集. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mistuoka,K.: "Effect of Maternal Uninephrectomy on the Development of Kidney in the Rat Proliferative Activity." Congenital Anomalies. 38・3. 314-314 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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