• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathogenicity and molecular structer of a newly isolated lethal and broad host range herpesvirus

Research Project

Project/Area Number 10660299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionGifu University Faculty of Agriculture

Principal Investigator

FUKUSHI Hideto  Gifu University Dept. Vet. Microbiol., Associate Professor, 農学部, 助教授 (10156763)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Tomio  JRA, Lab. Mol. Biol. Senior Researcher, 競走馬総合研究所・栃木支所・分子生物学研究室, 研究役
YAMAGUCHI Tsuyoshi  Gifu University Dept. Vet. Microbiol., Assistant Professor, 農学部, 助手 (70210367)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsherpesvirus / neuropathogenicity / hamster
Research Abstract

We investigated the pathogenicity of EHV-9 in horses. The horse inoculated with EHV-9 showed pyrexia, verifier and viral excretion in nasal discharge without any neurological symptoms. However, nonsuppurative encephalitis was confirmed. These results indicated that EHV-9 using hamsters. We serially passaged EHV-9 in the rabbit kidney cell line, RK-13. After 23 passages, we observed smaller plaques of EHV-9 in MDBK cells. This small plaque forming EHV-9 culture has less pathogencity in hamsters. We cloned the small plaque forming EHV-9. The cloned viruses also showed less pathogencity in hamsters. These results indicated that the plaque sizes in MDBK cells are related to the pathogenicity in hamsters.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] A.Taniguchi: "Pathogenicity of a new neurotropic equine herpesvirus 9 (Gazelle herpesvirus I) in horses"Journal of Veterinary Medical Science. 62. 215-218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Fukushi: "A hamster model of equine herpesvirus 9 induced encephalitis"Journal of NeuroVirology. 6(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A. Taniguchi et al.: "Pathogenicity of a new neurotropic equine herpesvirus 9."J. Vet. Med. Sci.. 62. 215-218 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Fukushi et al.: "A hamster model of equine herpesvirus 9 induced encephalitis."J. NeuroVirol.. 6(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.Taniguchi: "Pathogenicity of a new neurotropic equine herpesvirus 9 (Gazelle herpesvirus I) in horses"Journal of Veterinary Medical Science. 62. 215-218 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Fukushi: "A hamster model of equine herpesvirus 9 induced encephalitis"Journal of Neurovirology. 6(印刷中). (2000)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi