| Project/Area Number |
10670061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASE Satoshi Nagoya University, Research Institute of Environmental Medicine, Associate Professor, 環境医学研究所, 助教授 (90184879)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIYA Atsunori Nagoya University, Research Institute of Environmental Medicine, Assistant Professor, 環境医学研究所, 助手 (30324370)
NIIMI Yuki Nagoya University, Research Institute of Environmental Medicine, Assistant Professor, 環境医学研究所, 助手 (70314028)
間野 忠明 名古屋大学, 環境医学研究所, 教授 (30023659)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Skin sympathetic nerve activity / Thermoregulation / Skin blood flow / Sweating / Tympanic temperature / Vasoconstrictor / Microneurography / Heat loss |
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| Research Abstract |
Effect of thermally-dependent changes in skin sympathetic nerve activity on the tympanic temperature as the core temperature in the system of human thermoregulatory function was examined. Subjects were 42 men and women with written informed consent. Vasoconstrictive skin sympathetic nerve activity was recorded microneurographically from the tibial, peroneal, or median nerves using tungsten microelectrode with identification by skin blood flow reduction with laser Doppler flowmeter. Simultaneously tympanic temperature was recorded with thermister as the core temperature. Subjects were exposed to localized acute cold, systemic gradual cold, localized acute warmth, or systemic gradual warmth, and the correlation between the vasoconstrictive skin sympathetic nerve activity and the tympanic temperature was analyzed. In cold exposure, tympanic temperature was increased due to heat loss reduction caused by vasoconstrictive sympathetic activation. There established a linear correlation between vasoconstrictive activation and tympanic temperature rise with time lag of 10 min. Systemic gradual cold exposure enhanced vasoconstrictive skin sympathetic nerve activity by lowered tympanic temperature. The more enhancement, the less tympanic temperature lowered. On the other hand, localized heating lowered tympanic temperature by increasing heat loss caused by suppressed vasoconstrictive skin sympathetic nerve activity. The more suppressed the vasoconstricitve skin sympathetic nerve activity, the more lowered the tympanic temperature. The time lag between the sympathetic suppression and tympanic temperature reduction was 14 minutes. In conclusion, human thermoregulatory function largely depends on the activation and suppression of vasoconstrictive skin sympathetic nerve activity, and it was suggested that human body temperature is regulated feed-forwardly.
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