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Effects of menstrual cycles on the human circadian clock

Research Project

Project/Area Number 10670068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionYokohama City University

Principal Investigator

SHINOHARA Kazuyuki  Yokohama City University Assistant Professor, 医学部, 講師 (30226154)

Co-Investigator(Kenkyū-buntansha) FUNABASHI Toshiya  Yokohama City University Assistant Professor, 医学部, 講師 (70229102)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordscircadian rhythm / suprachiasmatic nucleus / estrogen / progesterone / gap junction / coupling / ギャップ結合 / 直腸温
Research Abstract

On the day of the estrous cycle during which blood levels of estradiol are high, female hamsters start their nocturnal activity phase earlier, This change in the locomotor activity rhythm throughout the estrous cycle may be caused by a direct effect of estrogen and progesterone on the circadian clock. However, it has not been reported that human females show a menstrual variation in circadian rhythms. We examined the effects of the menstrual cycle on circadian rhythms in 6 healthy women and 6 women with premenstrual syndrome (PMS). We measured circadian rhythms of wrist activity and temperature as well as plasma concentration of melatonin in the follicular phase (FP) and luteal phase (LP). In healthy women and PMS women, there was no menstrual change in circadian rhythms in sleep and temperature. However, the onset of the nocturnal melatonin rise was delayed by about 1 hr in the LP in PMS women although no phase shift was observed in healthy women. Therefore, estrous changes in circadian rhythm as observed in rats may be inhibited in human females. We observed a PMS woman who showed alternative phase shifts in the sleep, temperature and melatonin rhythms in the menstrual cycle : progressive phase advances in the follicular phase and phase delays in the luteal phase in a way similar to hamsters. We speculated that disturbance of the inhibition mechanism might be involved in this subject. To clarify the etiology of this disease, we examined the effects of 17β-estradiol (E2) on the expression of an interneuronal gap junction gene connexin-32 mRNA in the suprachiasmatic nucleus (SCN), the site of the circadian clock. E2 increased connexin-32 mRNA in the SCN. Dysfunction of interneuronal communication in the SCN bay be involved in the mechanism of this disease since we have shown that gap junction couple neurons in the rat SCN.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Shinohara K.: "Menstruol chonges in sleep, rectal temperature and melatonin rhythm in a sbject with premenstrual syndrome"Neuroscience Letters. 281. 159-162 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara K.: "Circadian release of excitatory amino acids in the suprachiasmatic nucleus is Ca^<2+>-independent"Neuroscience Research. 36. 245-250 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara K.: "GABAergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus"Neuroscience. 96. 591-596 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara k.: "Phase-dependent response of vasoactive intestinal polypeptide to light and darkness in the rat suprachiasmatic nucleus"Neuroscience Research. 33. 105-110 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara K.: "Temporal profiles of vasoactive intestinal polypeptide precursor mRNA and its receptor mRNA in the rat suprachiasmatic nucleus"Molecular Brain Research. 63. 262-267 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara K.: "Luminance-dependent decreasein vasoactive intestinal polypeptide in the suprachiasmatic nucleus of the rat"Neuroscience Letters. 251. 21-24 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K., uchiyama, M., Okawa, M., Saito, K., Kawaguchi, M., Funabashi, T. & Kimura, F.: "Menstrual changes in sleep, rectal temperature and melatonin rhythm in a subject with premenstrual syndrome."Neurosci. Lett.. 281. 159-162 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K., Honma, S., Katsuno, Y. & Honma, K.: "Circadian release of excitatory amino acids in the suprachiasmatic nucleus culture is CaィイD12+ィエD1-independent."Neurosci. Res.. 36. 245-250 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K., Hiruma, H., Funabashi, T., & Kimura, F.: "GABAergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus"neuroscience. 96. 591-596 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K., tominaga, K. & Inouye, S. I. T.: "Phase-dependent response of vasoactive intestinal polypeptide to light and darkness in that rat suprachiasmatic nucleus."Neurosci. Res.. 33. 105-110 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K. Funabashi, T, & Kimura, F.: "Temporal profiles of vasoactive intestinal polypeptide precursor mRNA and its receptor mRNA in the rat suprachiasmatic nucleus."Mol. Brain Res.. 63. 262-267 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara, K., Tominaga, K. & Inouye, S. I. T.: "Luminance-dependent decrease in vasoactive intestinal polypeptide in the suprachiasmatic nucleus of the rat"Neurosci. Lett.. 251. 21-24 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shinohara K: "Menstrual changes in sleep,rectal temperature and melatonin rhythin in a subject with premenstrual syndrome"Neuroscience Letters. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Shinohara K: "Circadian release of excitatory aminoacids in the suprachiasmatic nucleus is Ca^<2+>-indepenclent"Neuroscience Research. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Shinohara K: "GABA ergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus"Neuroscience Research. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Shinohara K: "Phase-dependent response of vasoactive inlestinal polypeptide to light and darkness in the rat suprachi asmatic uucleus"Neuroscience Research. 33. 105-110 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shinohara,K.: "Luminance-dependent decrease in vasoactive intestinal polypeptide in the rat suprachiasmatic nucleus" Neurosuence Letters. 251. 21-24 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shinohara,K.: "Circadian velease of amino acids in the suprachiasmatic nucleus in vitro" Neuro Report. 9. 137-140 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shinohara,K.: "Temporal profiles of vasoactive intestinal pdypeptide precursor mRNA and its receptor mRNA in the rat" Molecular Brain Research. 63. 262-267 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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