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Regulation of endothelin receptor expression through cancer cell differentiation

Research Project

Project/Area Number 10670084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionTottori University

Principal Investigator

NINOMIYA Haruaki  Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (80212124)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Yasuo  Kyoto University, Faculty of Medicine, Assistant Professor, 大学院・医学研究科, 助手 (80293877)
Project Period (FY) 1998 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsendothelin / receptor / cancer / melanoma / apoptosis / Niemann-Pick / cholesterol / カベオラ / コレステロール / がん
Research Abstract

In the current study, we focused on the ET-1-activated signal transduction pathways in cancer cells and found that ET-1, via activation of ETB receptors, induced expression of p53 and apoptotic cell death of A375 melanoma cells. There was a threshold value of ETB receptor densities expressed by individual cells to induce these responses and the receptor densities were controlled by a cell-cycle-dependent manner. We also found that ET-1/ETA complexes can be internalized both via clathrin-coated pits and caveolae and that the pathway selection was controlled by cholesterol contents of the plasma membrane. In relation to the latter finding, we analyzed the function of Niemann-Pick C1 protein that plays a critical role in the maintenance of cellular cholesterol homeostasis. We found that in addition to its critical role in cholesterol outflow from the late endosome, NPC1 protein is involved in the transport of GM1 ganglioside from the early endosome to the plasma membrane. This finding suggested that the internalization of ET-1/ETA complexes could be controlled by NPC1 in an indirect manner. Thus, the current study gave new insights both to the ET-1-induced signal transduction and the internalization mechanism of ET-1/receptor complexes.

Report

(5 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (72 results)

All Other

All Publications (72 results)

  • [Publications] Hosokawa et al.: "Vascular endothelial cells that express dystroglycan are involved in angiogenesis"J.Cell Sci.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto et al.: "Novel TSC1 and TSC2 mutations in Japanese patients with tuberous sclerosis complex"Brain Dev.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugimoto et al.: "Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells"Proc.Natl.Acad.Sci.USA. 98. 12391-12396 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Taniguchi et al.: "Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain"Brain Dev.. 23. 414-421 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada et al.: "Progressive cell loss in the ventral posterior lateral and medial nuclei of thalamus in Niemann-Pick disease type C mice brain"Brain Dev.. 23. 288-297 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higaki et al.: "Protective effect of neutropin against LPS-induced hypotension and lethality linked to suppression of iNOS induction"Japan J.Pharmacol. 86. 329-335 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higaki et al.: "Isolation of NPCL-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis"J.Biochem.. 129. 875-880 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto et al.: "Antley-Bixler syndrome and maternal virilization : a proposal of genetic heterogenity"Clin.Genet. 59. 451-453 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sawamura et al.: "Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice"J.Biol.Chem.. 276. 10314-10319 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsukamato et al.: "SSCP analysis by RT-PCR for the prenatal diagnosis of Niemann-Pick disease type C"Prenat.Dig.. 21. 52-54 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto et al.: "DEFECT 11 syndrome associated with agenesis of corpus callosum"J.Med.Genet.. 38. E5 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ripo et al.: "Two novel serine repeat length polymorphisms (1043insS and 1043inssS) at exon 23 of the TSC1 gene"Hum.Mutat.. 16. 375 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto et al.: "Genotype-phenotype relationship of NPC : a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts"J.Med.Genet.. 37. 707-712 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata et al.: "A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome"J.Hum.Genet.. 45. 237-240 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikumi et al.: "Fibrillin gene (FBN1) mutations in Japanese patients with Marfan syndrome"J.Hum. Genet.. 45. 115-118 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto et al.: "Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in CHO cells"J.Biol.Chem.. 275. 6439-6446 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang et al.: "Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex"J.Hum.Genet.. 44. 391-396 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hosokawa et al.: "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain"Brain Res.. 838. 158-165 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto et al.: "NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C"Hum.Genet.. 105. 10-16 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu et al.: "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan"J.Biol.Chem.. 274. 11995-12000 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inui et al.: "Selective activation of excitation-contraction coupling pathways by ETA and ETB receptors in guinea pig tracheal smooth muscle"Br.J.Pharmacol.. 126. 893-902 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang et al.: "Role of nonselective cation channels as Ca^<2+> entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide"Eur.J.Pharmacol.. 352. 237-245 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ninomiya et al.: "Paracrine endothelin signaling in the control of basal cell proliferation in guinea pig tracheal epithelium"J.Pharmacol.Exp.Ther.. 286. 469-480 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okazawa et al.: "Endothelin-induced apoptosis of A375 melanoma cells"J.Biol.Chem.. 273. 12584-12592 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hosokawa H., Ninomiya H., Kitamura Y., Fujiwara K. and Masaki T.: "Vascular endothelial cells that express dystroglycan are involved in angiogenesis"J. Cell Sci.. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T., Pipo J.R., Heng J-.H., Takeda H., Nanba E., Maegaki Y., Ninomiya H., Ohno K.: "Novel TSC1 and TSC2 mutations in Japanese patients with tuberous sclerosis complex"Brain Dev.. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugimoto Y., Ninomiya H., Ohsaki Y., Higaki K., Davies J.P., Ioannou Y.A. and Ohno K.: "Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells"Proc. Natl. Acad. Sci. USA, 98. 12391-12396 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Taniguchi M., Shinoda Y., Ninomiya H., Vanier M.T. and Ohno K.: "Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain"Brain Dev.. 23. 414-421 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada A., Saji M., Ukita Y., Shinoda Y., Taniguchi M., Higaki K., Ninomiya H. and Ohno K.: "Progressive cell loss in the ventral posterior lateral and medical nuclei of thalamus in Niemann-Pick disease type C mice brain"Brain Dev.. 23. 288-297 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higaki K., Ninomiya H., Saji M., Maki H., Koike T. and Ohno K.: "Protective effect of neutropin against LPS-induced hypotension and lethality linked to suppression of iNOS induction"Japan. J. Pharmacol.. 86. 329-335 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Higaki K., Ninomiya H., Sugimoto Y., Suzuki T., Niwa H., Pentchev P.G., Vanier M.T. and Ohno K.: "Isolation of NPC1-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis"J. Biochem.. 129. 875-880 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T., Pipo J.R., Ninomiya H., Ieshima A. and Koeda T.: "Antley-Bixler syndrome and maternal virilization : a proposal of genetic heterogenity"Clin. Genet.. 59. 451-453 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sawamura N., Gong J-.S., Garver W.S., Ninomiya H., Ohno K., Yanagisawa K. and Michikawa M.: "Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice"J. Biol. Chem.. 276. 10314-10319 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsukamoto H., Yamamoto T., Nishigaki T., Sakai N., Nanba E., Ninomiya H., Ohno K., Inui K. and Okada S.: "SSCP analysis by RT-PCR for the prenatal diagnosis of Niemann-Pick disease type C"Prerat. Diag.. 21. 52-54 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T., Akaboshi S., Ninomiya H. and Nanba E.: "DEFECT 11 syndrome associated with agenesis of corpus callosum"J. Med. Genet.. 38. ES (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Pipo J.R., Yamamoto T., Takeda H., Maegawa S., Nanba E., Ninomiya H., Ohno K. and Takeshita K.: "Two novel serine repeat length polymorphisms (1043insS and 1043inssS) at exon 23 of the TSC1 gene"Hum. Mutat.. 16. 375 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T., Ninomiya H., Matsumoto M., Ohta Y., Nanba E., Tsutsumi Y., Yamakawa K., Millat G., Vanier M.T., Pentchev P.G. and Ohno K.: "Genotype-phenotype relationship of Niemann-Pick disease type C : a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts"J. Med. Genet.. 31. 707-712 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata K., Yamamoto T., Chikumi H., Ikeda T., Yamamoto H., Hashimoto K., Yoneda K., Nanba E., Ninomiya H. and Ishitobi K.: "A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome"J. Hum. Genet.. 45. 237-240 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikumi H., Yamamoto T., Ohta Y., Nanba E., Nagata K., Ninomiya H., Narasaki K., Katoh T., Hisatome I., Ono K., Tanaka Y., Kuroda H. and Ohgi S.: "Fibrillin gene (FBN1) mutations in Japanese patients with Marfan syndrome"J. Hum. Genet.. 45. 115-118 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto Y., Ninomiya H., Miwa S. and Masaki T.: "Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in Chinese hamster ovary cells"J. Biol. Chem.. 275. 6439-6446 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang H., Yamamoto T., Nanba E., Ninomiya H., Ohno K., Mizuguchi M. and Takeshita K.: "Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex"J. Hum. Genet.. 44. 391-396 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hosokawa H., Ninomiya H., Sawamura T., Sugimoto Y., Ichikawa A., Fujiwara K. and Masaki T.: "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain"Brain Res.. 838. 158-165 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T., Nanba E., Ninomiya H., Higaki K., Taniguchi M., Zhang H., Akaboshi S., Watanabe Y., Takeshima T., Inui K., Okada S., Tanaka A., Sakuragawa N., Millat G., Vanier M.T., Morris J.A., Pentchev P.G. and Ohno K.: "NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C"Hum. Genet.. 105. 10-16 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu H., Hosokawa H., Ninomiya H., Miner J.H. and Masaki T.: "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan"J. Biol. Chem.. 274. 11995-12000 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inui T., Ninomiya H., Sasaki Y., Makatani M., Urade Y., Masaki T. and Yamamura T.: "Selective activation of excitation-contraction coupling pathways by ETA and ETB receptors in guinea pig tracheal smooth muscle"Br. J. Pharmacol.. 126. 893-902 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang X.F., Komuro T., Miwa S., Minowa T., Iwamuro Y., Okamoto Y., Ninomiya H., Sawamura T. and Masaki T.: "Role of nonselective cation channels as Ca^<2+> entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide"Eur. J. Pharmacol.. 352. 237-245 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ninomiya H., Inui T. and Masaki T.: "Paracrine endothelin signaling in the control of basal cell proliferation in guinea pig tracheal epithelium"J. Pharmacol. Exp. Ther.. 286. 469-480 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okazawa M., Shiraki T., Ninomiya H., Kobayashi S. and Masaki T.: "Endothclin-induced apoptosis of A375 melanoma cells"J. Biol. Chem.. 273. 12584-12592 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hosokawa et al.: "Vascular endothelial cells that express dystroglycan are involved in angiogenesis."J. Cell Sci.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugimoto et al.: "Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells"Proc. Natl. Acad. Sci. USA. 98. 12391-12396 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Taniguchi et al.: "Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain"Brain Dev.. 23. 414-421 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada et al.: "Progressive cell loss in the ventral posterior lateral and medial nuclei of thalamus in Niemann-Pick disease type C mice brain"Brain Dev.. 23. 288-297 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Higaki et al.: "Isolation of NPC1-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis"J. Biochem. 129. 875-880 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sawamura et al.: "Site-specific phosphorylation of tau accompanied by activation of mirogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice"J. Biol. Chem.. 276. 10314-10319 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sawamura N. et al.: "Site-specific phosphorylation of tau accompanied by activation of mitogenactivated protein kinase (MAPK) in brains of Niemann-Pick type C mice."J.Biol.Chem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsukamoto H. et al.: "SSCP analysis by RT-PCR for the prenatal diagnosis of Niemann-Pick disease type C."Prenat.Diag.. 21. 52-54 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagata K. et al.: "A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome."J.Hum.Genet.. 45. 237-240 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chikumi H. et al.: "Fibrillin gene(FBN1)mutations in Japanese patients with Marfan syndrome."J.Hum.Genet.. 45. 115-118 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamoto T. et al.: "Genotype-phenotype relationship of Niemann-Pick disease type C : a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts."J.Med.Genet.. 37. 707-712 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okamoto Y. et al.: "Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in Chinese hamster ovary cells."J.Biol.Chem.. 275. 6439-6446 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okamoto Y.et al.: "Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in Chinese hamster ovary cells"J.Biol.Chem.. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Zhang H,et al.: "Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex"J,Hum,Genet.. 44. 391-396 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hosokawa H.et al.: "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain"Brain Res.. 838. 158-165 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto T.et al.: "NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C."Hum.Genet.. 105. 10-16 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu H,et al.: "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan"J.Biol.Chem.. 274. 11995-12000 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inui T.et al.: "Selective activation of excitation-contraction coupling pathways by ET_A and ET_B receptors in guinea pig tracheal smooth muscle"Br.J.Pharmacol.. 126. 893-902 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okamoto Y.et al.: "Cysteine residues in the carboxy1-terminus of human endothelin_B are critical for its coupling with G proteins." Journal of Cardiovascular Pharmacology. 31. S230-232 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okazawa M.et al.: "Endothelin-induced apoptosis of A375 melanoma cells." Journal of Biological Chemistry. 273. 12584-12592 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ninomiya H.et al.: "Paracrine endothelin signaling in the control of basal cell proliferation in guinea pig tracheal epithelium." Journal of Pharmacology and Experimental Therapeutics. 286. 469-480 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zhang X.F.et al.: "Role of nonselective cation channels as Ca^<2+> entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide." European Journal of Pharmacology. 352. 237-245 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inui T.et al.: "Selective activation of excitation-contraction coupling pathways by ET_<Aa> and ET_B receptors in guinea pig tracheal smooth muscle." British Journal of Pharmacology. 126. 893-902 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimizu H.et al.: "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan." Journal of Biological Chemistry. (in press).

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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