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Molecular analysis of tumorigenesis human ependymoma.

Research Project

Project/Area Number 10670163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

IWAKI Toru  Graduate School of Medical Sciences, Kyushu University, Professor, 大学院・医学系研究科, 教授 (40221098)

Co-Investigator(Kenkyū-buntansha) SUZUKI Satoshi o  Graduate School of Medical Sciences, Kyushu University, Instructor, 大学院・医学系研究科, 助手 (90294917)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsbrain tumor / ependymoma / oncogene / SV40 / p53 / MDM2
Research Abstract

Ependymomas rarely show p53 gene alteration and the tumorigenic mechanism of ependymomas still remains to be elucidated. We herein investigated the amplification and overexpression of mdm2 gene, whose product (MDM2) is considered to be one of the major cellular regulators of p53-mediated growth control, in 26 specimens of ependymomas obtained from 20 patients. The majority of the ependymomatous samples (96%) showed at least focal immunopositivity for MDM2 ; however, only 8% of the samples were immunopositive for p53. Mdm2 gene amplification was detected in 35% of the samples by differential polymerase chain reaction, all of which overexpressed MDM2. These results suggest that the amplification and/or overexpression of mdm2 may thus be one of the major molecular events occurring in the tumorigenesis of ependymomas.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] S. O.Suzuki: "Amplication and overexpression of mdm2 gene in ependymomas."Modern Pathology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Mizoguchi: "Patient survival and microsatellite instablity in gliomas by high-resolution fluorescent analysis"Oncology Report. 6. 791-795 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] W. Thangnipon: "Distinct pattern of PCR-SSCO analysis of p53 mutations in human astrocytomas"Cancer Letters. 141. 195-201 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Mizoguchi: "Abnormal cytoarchitecture of cortical dysplasia verified by immunohistochemistry"Clinical Neuropathology. 17. 100-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Hamada: "Accumulation of class I mutant p53 and apoptosis induced by carboplatin in a human glioma cell line."Brain Tumor Pathology. 15. 77-82 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Mizoguchi: "Acomparative immunohistochemical study of tissue transglutaminase and factor XIIIa in hemangioblastoma."Neuropathology. 18. 199-205 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S.O., Iwaki T.: "Amplication and overexpression of mdm2 gene in ependymomas."Mod. Pathol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizoguchi M., Inamura T., Ikezaki K., Iwaki T., Oda S., Maehara Y., Oki E., Terasaki M., Fukui M.: "Patient survival and microsatellite instability in gliomas by high-resolution fluorescent analysis."Oncology Report. 6. 791-795 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Thangnipon W., Mizoguchi M., Kukita Y., Inazuka M., Iwaki T., Fukui M., Hayashi K.: "Distinct pattern of PCR-SSCP analysis of p53 mutations in human astrocytomas."Cancer Letters. 141. 195-201 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizoguchi M., Iwaki T., Morioka T., Fukui M., Tateishi J.: "Abnormal cytoarchitecture of cortical dysplasia verified by immunohistochemistry."Clinical Neuropathology. 17. 100-109 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamada Y., Mizoguchi M., Suzuki S.O., Iwaki T.: "Accumulation of class I mutant p53 and apoptosis induced by carboplatin in human glioma cell line."Brain Tumor Pathology. 15. 77-82 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizoguchi M., Iwaki T., Fukui M.: "A comparative immunohistochemical study of tissue transglutaminase and factor XIIIa in hemangioblastoma."Neuropathology. 18. 199-205 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.O.Suzuki: "Amplification and overexpression of mdm2 gene in ependymomas"Modern Pathology. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Mizoguchi: "Patient survival and microsatellite instability in gliomas by high-resolution fluorescent analysis"Oncology Report. 6. 791-795 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] W.Thangnipon: "Distinct pattern of PCR-SSCP analysis of p53 mutations in human astrocytomas"Cancer Letters. 141. 195-201 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Mizoguchi: "Abnormal cytoarchitecture of cortical dysplasia verified by immunohistochemistry"Clinical Neuropathology. 17. 100-109 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Hamada: "Accumulation of class I mutant p53 and apoptosis induced by carboplatin in a human glioma cell line"Brain Tumor Pathology. 15. 77-82 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Mizoguchi: "A comparative immunohistochemical study of tissue transglutaminase and factor XIIIa in hemangioblastoma"Neuropathology. 18. 199-205 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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