| Project/Area Number |
10670183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
|
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKATA Noriyuki School of Medicine, Professor, 医学部, 教授 (20134273)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MENG Jing School of Medicine, Assistant Professor, 医学部, 助教授 (50299567)
MATSUNAGA Akira School of Medicine, Assistant Professor, 医学部, 助教授 (60221587)
TASHIRO Tadashi School of Medicine, Assistant Professor, 医学部, 助教授 (20268981)
佐々木 淳 福岡大学, 医学部, 助教授 (90122697)
|
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| Project Period (FY) |
1998 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
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| Keywords | Serum abumin / Low-density Lipoprotein / Glycoxidation / Antioxidant activity / Lipid peroxidation / Oxidation / Carboxymethyllysine / Malondialdehyde / 低比重リポ蛋白 / 後期反応生成物 / 糖化 / 粥状硬化 / 免疫化学 / 免疫組織化学 / 酸化フォスファチジールコリン / 糖酸化反応産物 |
|---|
| Research Abstract |
N^ε-(carboxymethyl)lysine was formed in glycoxidative human serum albumin (HSA), butnot in oxidative HSA.
Glycoxidation and oxidation of HSA significantly decreased the contents of free thiol groups.
The antioxidant activity of glycoxidative HSA to LDL-oxidation was the lowest among various modified HSAS.
Oxidative HSA showed a moderate decrease in antioxidant activity.
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