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Molecular pathology of stomach and esophagus carcinogenesis induced br duodenal reflux containing bile - a concern of UACL (ulcer-associated cell lineage) to carcinogenesis

Research Project

Project/Area Number 10670201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionShiga University of Medical Science

Principal Investigator

HATTORI Takanori  Shiga University of Medical Science, Pathology, Professor, 医学部, 教授 (70079721)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsstomach / carcinogenesis / bile reflux / duodenal juice reflux / gastritis cystica profunds / UACL / trefoil peptide / pS2 / 胃癌 / 残胃癌 / 胆汁 / 十二指腸液 / パレット食道
Research Abstract

The current study was undertaken how duodenal contents cause a mucosal damage leading to carcinogenesis. In recent years, attentions have been focused on expression of trefoil peptides in the normal and damaged gastrointestinal mucosa, whereas little was known about their function. In this study, a special attention has been focused on the function of the peptides, and an implication of trefoil peptides expression in the reflux carcinogenesis was studied. Research results, were, (1) by the experiments using human colonic and gastric cancer cell lines, one of trefoil peptides TFF3 has a function of controlling the expression of the APC-catenin and the E-cadherin-catenin complexes, thereby indicating the regulatory functions of cell proliferation related to movements and anchoring of epithelial cells, and (2) by the reflux operation, gastric and esophageal cancers could be induced after 75 weeks. Before 75 weeks, precancerous lesions were studies. In all rats, cystic proliferation of mucous glands, identical with those reported by Wright as UACL, and UACLs expressed pS2 and TFF3, and they were shown to become carcinoma cells.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] J. A Efstathiou, et al.: "Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells"Proc. Natl. Acad. Sci. USA. 95. 3122-3127 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wu, LB., et al.: "Intramucosal carcinomas of the stomach : phenotypic expression and loss of heterozygosity at microsatellites linked to the APC Gene"Pathol. Res. Pract.. 194. 405-412 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Bamba, M., et al.: "Clonal analysis of superficial depressed-type gastric carcinoma in humans"Cancer. 83. 867-875 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yao, XH., et al.: "Regulation of apoptotic cell death in the pyloric glands of the canine stomach"Virchows Arch. 433. 275-280 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikehara, Y., et al.: "The aberrant expressional of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression"Glycoconjugate Journal. 15. 799-807 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura T., et al.: "Microsatellite analysis and DNA ploidy pattern in signet-ring cell carcinoma and well differentiated adenocarcinoma of the stomach"The Cancer Journal. 11. 298-305 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kushima, R., et al.: "Histogenesis of gastric faveolar metaplasia following duodenal ulcer : a definite reparative lineage of Brunner's gland"Histopaathology. 35. 38-43 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura, T., et al.: "Expression of fibroblast growth factor-2transcripts in the healing of acetic acid-induced gastric ulcers"APMIS. 107. 767-772 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kushima, R., et al.: "'Pyloric gland-type adenoma' arising in heterotopicgastric mucosa of theduodenum, with dysplastic progression of the gastrictype"Virchows Arch. 435. 452-457 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanemasa, H., et al.: "Distribution of gluco-corticoid receptor immunoreactivity in gastric mucosa of normal and adrenalectomized rats"Digestive Diseases and Sciences. 44. 2081-2087 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiomi, H., et al.: "Cellular distribution and clinical value of urokinase-type plasminogen activator, its teceptor and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma"The American Journal of Pathology. 156. 567-575 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Efstathiou, J.A. et al.: "Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells"Proc. Natl. Acad. Sci. USA. 95. 3122-3127 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wu, LB. et al.: "Intramucosal carcinomas of the stomach : phenotypic expression and loss of heterozygosity at microsatellites like linked to the APC Gene"Pathol Res. Pract.. 194. 405-412 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Bamba, M. et al.: "Clonal analysis of superficial depressed-type gastric carcinoma in humans"Cancer. 83 (5). 867-875 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yao XH. et al.: "Regulation of apoptotic cell death in the pyloric glands of the canine stomach"Virchows Arch. 433. 275-280 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikehara, Y. et al.: "The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression"Glycoconjugate journal. 15. 799-807 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura, H. et al.: "Microsatellite analysis and DNA ploidy pattern in signet-ring cell carcinoma and well differentiated adenocarcinoma of the stomach"The Cancer Journal. 11(6). 298-305 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kushima, R. et al.: "Histogenesis of gastric foveolar metaplasia following duodenal ulcer : a definite reparative lineage of Brunner's gland"Histopathology. 35. 38-43 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura, T. et al.: "Expression of fibroblast growth factor-2 transcripts in the healing of acetic acid-induced gastric ulcers"APMIS. 107. 767-772 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kushima, R. et al.: "Pyloric gland-type adenoma' arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type"Virchows Arch. 435. 452-457 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanemasa, H. et al.: "Distribution of glucocorticoid receptor immunoreactivity in gastric mucosa of normal and adrenalectomized rats"Dig. Dis. & Sci.. 44(10). 2081-2087 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiomi, H. et al.: "Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma"Amer. J. Pathol.. 156. 565-575 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.A Efstathiou et al.: "Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells"Proc. Natl. Acad. Sci. USA. 95. 3122-3127 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wu LB. et al.: "Intramucosal carcinomas of the stomach: phenotypic expression and loss of heterozygosity at microsatellites linked to the APC Gene"Pathol. Res. Pract.. 194. 405-412 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Bamba M. et al.: "Clonal analysis of superficial depressed-type gastric carcinoma in humans"Cancer. 83・5. 867-875 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yao XH. et al.: "Regulation of apoptotic cell death in the pyloric glands of the canine stomach"Virchows Arch. 433. 275-280 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikehara Y. et al.: "The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression"Glycoconjugate Journal. 15. 799-807 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura T. et al: "Microsatellite analysis and DNA ploidy pattern in signet-ring cell carcinoma and well differentiated adenocarcinoma of the stomach"The Cancer Journal. 11・6. 298-305 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kushima R. et al.: "Histogenesis of gastric foveolar metaplasia following duodenal ulcer: a definite reparative lineage of Brunner's gland"Histopathology. 35. 38-43 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kimura T. et al: "Expression of fibroblast growth factor-2 transcripts in the healing of acetic acid-induced gastric ulcers"APMIS. 107. 767-772 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kushima R. et al.: "'Pyloric gland-type adenoma'arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastrictype"Virchows Arch. 435. 452-457 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanemasa H. et al: "Distribution of gluco-corticoid receptor immunoreactivity in gastric mucosa of normal and adrenalectomized rats"Digestive Diseases and Sciences. 44・10. 2081-2087 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiomi H. et al: "Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma"The American Journal of Pathology. 156. 567-575 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 服部隆則,他: "残胃癌の発生病理" 消化器科. 26(3). 311-317 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Li-Bo Wu,et al: "Phenotypic Expression and Loss of Heterozygosity at Microsatellites Linkes Linked to APC Gene." Pathol.Res.Pract.194. 405-412 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masamichi Bamba,et al: "Clonal analysis of superficial Depressed-Type Gastric Carcinoma in Humans." Cancer. 83(5). 867-875 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yuzuru Ikehara,et al: "The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression." Glycoconjugate Journal. 15. 799-807 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Kimura,et al: "Microsatellite analysis and DNA ploidy pattern in signet-ring cell carcinoma and well differentiated adenocarcinoma of the stomach." The Cancer Journal. 11(6). 298-305 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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