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Molecular analysis of pathogenicity congenital toxoplasmosis

Research Project

Project/Area Number 10670225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 寄生虫学(含医用動物学)
Research InstitutionChiba University

Principal Investigator

YANO Akihiko  Chiba University, School of Medicine, Professor, 医学部, 教授 (20135122)

Co-Investigator(Kenkyū-buntansha) HATA Hidekazu  Chiba University, School of Medicine, Assistant, 医学部, 助手 (00110304)
NOROSE Kazumi  Chiba University, School of Medicine, Assistant, 医学部, 助手 (30156244)
AOSAI Fumie  Chiba University, School of Medicine, Associate Professor, 医学部, 助教授 (80150316)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsCongenital toxoplasmosis / IFN-g KO mouse / HSP70 / T.g.HSP70 / IFN-γ / Toxoplasma gondii / stage conversion / NO / IFN-γKO / 細胞傷害性T細胞 / 胎盤免疫 / 細胞内寄生原虫
Research Abstract

In order to establish a mouse experimental model of congenital toxoplasmosis by using INF-γ, TNF-α, and NKT KO pregnant mice were examined the infectivity of Toxoplasma gondii (T.gondii) (a cyst forming strain, Fukaya) to their fetuses. In IFN-g KO mouse model, 100% of placentas, 62% of fetal livers and 30% offetal brains of the new born babies from T.gondii-infected IFN-g KO pregnant mice were obtained. None of the babies of other strains were infected. Thus, an experimental congenital toxoplasmosis model has been established by using IFN-g KO mice. IFN-γ was shown to function as an abortion inducing factor to T.gondii-infected pregnant mice as well as anti-T.gondii function.
One of the molecular mechanism of such bi-functional activity of IFN-γ was mediated by induction of NO synthesis from macrophages that caused tissue damage and anti-T.gondii activity. IFN-γ was shown to mediate anti-T.gondii activity in fetal livers and brains. Furthermore, IFN-γ induced the conversion of T.gondii from tachyzoites to bradyzoites at the placenta.
We have cloned the full length HSP70 of Toxoplasma gondii (T.g.HSP70) which has been revealed to act as a virulent gene, or danger signal in T.gondii-infected mice. Using differential display method to analyze the genes controlling the susceptibility/resistance of mice to T.gondii infection, IFN-γ, TNF-α, IL-4, IL-5, STAT-1, STAT-2, IRF-1 genes were shown to be involved. Furthermore, more than 12 candidate genes are speculated to be involved in protective immunity to T.gondii infection. Fine analysis of these genes is underway.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (55 results)

All Other

All Publications (55 results)

  • [Publications] Hata H.,Aosai F.,Mun H-S.,Chen M.,Kobayashi M.,Khairul Anuar Abdulah,Kubosawa H.,Yano A.: "Identification of Toxoplasma gondii tachyzoites and bradyzoityes by a quantitative competitive polymerase chain reactyion method after the acid treatment"Jpn. J. Trop. Med. Hyg.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakazaki S.,Saeki N.,Itoh S.,Osato K.,Watanabe O.,Hamada N.,Yano A.,Mitsuhashi H.,Shin H.,Kiuchi I.,Kobayashi C.,and Yamaura A.: "Toxoplasmic encehalitis in patients with aquired immune deficiency syndrome. -For case Reports-"Neurologia medico-chirurgica (Tokyo). 40. 120-123 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐野純子、斎藤寛和、小林義典、池田真人、小谷英太郎、高山守正、岸田浩、高野照夫、矢野明彦: "心膜液ポリメラーゼ連鎖反応によって診断された基礎疾患のないトキソプラズマ心膜炎の1例"日本心臓学会誌 (J. Cardiol). 35. 47-54 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aosai F.,Hye-Seong Mun,Norose K.,Mei Chen,Hata H.,Kobayashi M.,Kiuchi M.,Stauss H.J.,Yano A.: "Protective immunity induced by vaccination with SAG1-gene transfected cells against Toxoplasma gondii-infection in mice"Microbiol. Immunol.. 43. 87-91 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mun,Hye-Seong,Fumie Aosai,Akihiko Yano: "Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii"Microbiol. Immunol.. 43. 471-479 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kobayashi M.,Fumie Aosai,Hata H.,Mun H-S,Tagawa Y.,Iwakura Y.,Yano A.: "Toxoplasma gondii : Difference of invasion into the tissues of digestive organs between susceptible and resistant strain and influence of IFN-γ in mice inoculated with the cyst perorally"J. Parasitol.. 85. 973-975 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kairuhl Anuar A.,Phamah N.,Dighe V. C.,Zurainee M.N.,Suresh K.,& Yano A.: "Antigen specific lymphocyte proliferative response of patients with acute and chronic toxoplasmosis"JUMMEC. 1. 1-5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 廣島健三、豊崎哲也、伊豫田明、大和田英美、青才文江、小林仁、畑英一、矢野明彦、由佐俊和: "ヒト肺糸状虫症の病理学的検討"日本臨床寄生虫学会雑誌. 9. 30-32 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yuki K.and Yano A.: "Huumoral immune responses against members of the hsp70 family in Toxoplasma gondii"Jpn. J. Trop. Med. Hyg.. 26. 305-318 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata Hidekazu,Niimura Munetoshi,Yano Akihiko.: "Angiostrongylus costaricensis : Purine and Pyrimidine nucleotide biosyntheses"J. Vet. Med. Sci.. 60. 1153-1155 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamashita K.,Yui K.,Ueda M.,and Yano A.: "CTL-mediated lysis of Toxoplasma-infected target cells does not lead to death of the instracellular parasites"Infect. Immun.. 60. 4651-4655 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鈴木保宏、竹本理、荒井洋、後藤めぐみ、山田淳二、森本一良、中山雅弘、仁木康之、矢野明彦: "胎盤より確定診断し得た先天性トキソプラズマ症の1例"脳と発達. 30. 411-416 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高橋好行、山口豊、鈴木実、斉藤幸雄、馬場雅行、藤沢武彦、広島健三、大和田英美、小林仁、矢野明彦: "空洞を伴う多発結節を呈したヒト犬糸状虫症の1例"日本臨床外科学会雑誌. 59. 674-677 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Khairul Anuar A.,Zulkifila A.,Atiya A. S.,Yano A.: "Effect of deworming on growth in a primary intervention program among primary school children in Kelantan, Malysia. Collected papers on the control of soil-transmitted helminthiasis."The Asian Parasite Control Organization. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦: "伊藤正男、井村裕夫、高久史麿篇 医学書院医学大辞典 (8項目)"医学書院、東京 (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦: "ペリネイタルケア ; 予防対策から考える周産期の感染症 -トキソプラズマ症- 末原則幸篇"メディカ出版. 12 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦: "新女性医学大系第10巻 感染症各論 母児感染 「トキソプラズマの診断、胎児診断」"中山書店. 9 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦、青才文江: "大鶴正満、亀谷了、林慈生 監修 日本における寄生虫学の研究6 「原虫感染における抗原提示」"目黒寄生虫館. 12 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦: "山崎修道、井上栄、大久保一郎、神谷斉、倉田毅、小池麒一郎、竹内勤、千葉俊三、箕輪真澄編 感染症予防必携"日本公衆衛生協会. 4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 矢野明彦: "石井明、鎮西康雄、太田伸夫編 標準医動物学 (第2版) 消火器・泌尿生殖器寄生鞭毛虫"医学書院、東京. 3 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.Yano,H-S.Mun,T-H.Yang,H.Hata,M.Kobayashi,K.Norose,S.Hayakawa,Y.Tagawa,Y.Iwakura,S.Nakazaki,Y.Nakazaki,S.Sekiya,A.Yamaura,H.Kubosawa,N.Yumoto,F.Aosai.: "ICOPA IX-9th International Congress of Parasitology, ed. Isao Tada, Somei Kojima, Miriyasu Tsuji. Blogna, Italy. Monduzzi Editore"Roles of IFN-gamma in effector mechanisms and pathogenicity of HSPs in mice and human infected with Toxoplasma gondii.. 10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] F.Aosai,H-S.Mun,T-H.Yang,K.Norose,H.Hata,M.Kobayashi,M.Chen,S.Saito,N.Rikihisa,M.Ichinose,A.Yano: "ICOPA IX-9th International Congress of Parasitology, ed. Isao Tada, Somei Kojima, Miriyasu Tsuji. Blogna, Italy. Monduzzi Editore"HSC70-mediated antigen presentation and ex-vivo gene vaccination with SAG1 to Toxoplasma gondii-infection.. 7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mun H-Se,Aosai F.,Kobayashi M.,Hata H.,Chen M.,Byun D-S.,Yano A.,: "Proceedings of the 4th Korea-Japan Parasoitologists'Seminar vol.4 Parasoitologists'Seminar"Vaccine effects of Toxoplasma-derived chaperone molecules in mice.. 9 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, H., Aosai, F., Mun, H-S., Chen, M., Kobayashi, M., Khairul Anuar Abdullah, Kubosawa, H., and Yano, A.: "Identification of Toxoplasma gondii tachyzoites and bradyzoityes by a quantiative compentitive polymerase chain reactyion method after the acid treatment."Jpn. J. Trop. Med. Hyg.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Khairul Anuar A., Zulkifila A., Atiya A. S., and Yani, A.: "Effect of deworming on growth in a primary intervention among primary school Kelantan, Malysia."Collected papers on the control of soli-transmitted program children in helminthiasis. Ed. The Asian Parasite Control Organization.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakazaki, S., Saeki, N., Itoh, S., Osato, K., Watanabe, O., Hamada, N., Mitsuhashi, H., Shin, H., Kikuchi, I., Kobayashi, C., Yano, A., and Yamayra, A.: "Toxoplasmic encephalitis in patients with aquired immune deficiency syndrome-four case reports-."Neurologia medico- chirurgica. 40(2). 120-123 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aosai, F., Mun, H-S., Norose, K., Chen, M., Hata, H., Kobayashi, M., Kikuchi, M., Stauss, H. J., and Yani, A.: "Protective immunity induced by vaccination with SAG1 -gene transfected cells against Toxoplasma gondii -infection in mice."Microbiol. Immunol.. 45(3). 87-91 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mun, H-S., Aosai, F., and Yano, A.: "Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and Prophylactic immunity in mice experimentally infected with Toxoplasma gondii."Microbiol. Immunol.. 43(5). 471-479 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kobayashi, M., Aosai, F., Hata, H., Mun H-S., Tagawa, Y., Iwakura, Y., and Yano, A.: "Toxoplasma gondii : Difference of invasion into the tissues of digestive organs between susceptible and resistant strain and influence of IFN-γ in mice inoculated with cyst perorally."J Parasitol.. 85(5). 973-975 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kairuhl Anuar, A., Rhamah, N., Dighe, V. C., Zurainee M.N., Suresh K., and Yano, a.: "Antigen specific lymphocyte proliferative response of patients with acute and chronic toxoplasmosis."JUMMEC. 1. 1-5 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yui, K. and Yano, A.: "Humoral immune responses against members of the hsp70 family in Toxoplasma gindii."Jpn. J. Trop. Med. Hyg.. 26(4). 305-318 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, H., Nimura, M., and Yano, A.: "Angiostongylus costaricensis : Purine and Pyrimidine nucleotide biosyntheses."J. Vet. Med. Sci.. 60(10). 1153-1155 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamashita, K., Yui, K., Ueda, M., and Yano, A.: "CTL-mediated lysis of Toxoplasma-infected target cells does not lead to death of the intracelluar parasites."Infect. Immun.. 60(10). 4651-4655 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mun, H-S., Aosai F., Kobayashi, M., Hata H., Chen M., Byun, D-S., and Yano, A.: "Vaccine effects of Toxoplasma -derived chaperone molecules in mice."Priceedings of the 4th Korea-Japan Parasoitologists' Seminar. vol.4. 42-50 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yano, A., H-S Mun, T-H. Yang, H. Hata, M. Kobayashi, K. Norose, S. Y. Tagawa, Y. Iwakura, S. Nakazaki, Y. Nakazaki, S Sekiya, A. Yamaura, H. Kubosawa, N. Yumoto, and F. Aosai.: "Roles of IFN-gamma in effector mechanisms and pathogenicity of HSPs in mice and human infected with Toxoplasma gondii."ICOPA IX - 9th International Congress of Parasitology, ed. I. Tada, S. Kojima, M. Tsuji. Blogna, Italy. Monduzzi Editore.. 457-466 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aosai, F., H-S. Mun, T-H. Yang, K. Norose, H. Hata, M. Kobayashi, M. Chen, S. Saito, N. Rikihisa, M. Ichinose, and A. Yano.: "HSC70-mediated antigen presentation and ex-vivo gene veccination with SAG1 to Toxoplasma gondii -infection."ICOPA IX - 9th International Congress of Parasitology, ed. I. Tada, S. Kojima, M. Tsuji. Blogna, Italy. Monduzzi Editore. 69-75 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, H., Aosai F., Mun H-S., Chen,M., Kobayashi, M., Khairul Anuar Abdullah, Kubosawa H., Yano, A.: "Identification of Toxoplasma gondii tachyzoites and bradyzoityes by a quantitative competitive polymerase chain reactyion method after the acid treatment"Jpn. J. Trop. Med. Hyg.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakazaki S., Saeki N., Itoh S., Osato K., Watanabe O., Hamada N., Yano A., Mitsuhashi H., Shin H., Kiuchi I., Kobayashi C., and Yamaura A.: "Toxoplasmic encephalitis in patients with aquired immune deficiency syndrome. -For case Reports-"Neurologia medico-chirurgica (Tokyo). 40(2). 120-123 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐野純子、斎藤寛和、小林義典、池田真人、小谷英太郎、高山守正、岸田浩、高野照夫、矢野明彦: "心膜液ポリメラーゼ連鎖反応によって診断された基礎疾患のないトキソプラズマ心膜炎の1例"(日本心臓学会誌) J. Cardiol. 35. 47-54 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Aosai F., Hye-Seong Mun, Norose K., Mei Chen, Hata H., Kobayashi M., Kiuchi M, Stauss H.J., Yano A.: "Protective immunity induced by vaccination with SAG1-gene transfected cells against Toxoplasma gondii-Infection in mice"Microbiol. Immunol.. 43(3). 87-91 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mun, Hye-Seong, Fumie Aosai, Akihiko Yano: "Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii"Microbiol. Immunol.. 43(5). 471-479 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kobayashi, M., Fumie Aodai, Hata H., Mun H-S, Tagawa Y., Iwakura Y., Yano,A.: "Toxoplsama gondii: Difference of invasion into the tissues of degestive organs between susceptible and resistant strain and influence of IFN-γ in mice inoculated with the cyst perorally"J. Parasitol.. 85(5). 973-975 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kairuhl Anuar, A., Rhamah, N., Dighe, V.C., Zurainee M. N., Suresh K., & Yano, A.: "Antigen specific lymphocyte proliferative response of patients with acute and chronic toxoplasmosis"JUMMEC. 1. 1-5 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Khairul Anuar A., Zulkifila A., Atiya A.S., Yano A.: "Effect of deworming on growth in a primary intervention program among primary school children in Kekantan, Malysia. Collected papers on the control of soil-transmitted helminthiasis"The Asian Parasite Control Organization (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 矢野明彦: "伊藤正男、井村裕夫、高久史麿篇 医学書院医学大事典(8項目)"医学書院 (印刷中). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 矢野明彦: "末原則幸篇 ペリネイタルケア;予防対策から考える周産期の感染症 -トキソプラズマ症-"メディカ出版. 12 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 矢野明彦: "新女性医学大系 感染症各論 母児感染 「トキソプラズマの診断、胎児診断」"中山書店. 9 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yang,T-H.,Aosal,F.,Norose,K.,Mun H-S.and Yano,A.: "Heat shock cognate protein 71-associated peptides function as an epitope for T.gondii-specific CD^<4+> CTL." Microbiol.Immunol.41(1). 553-561 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] He N.,Aosai F.,Luo W.,Ueda M.,Yang T-H.,Yamashita K.,Souei Sekiya and Yano A.: "Parasite load in pregnant mice infected by Toxoplasma gondii assayedby quantitative competitive-PCR." Pasitol.Int.46. 143-147 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yano A.,Aosai F.,Yang T-H.,He N.,Mun H-S.,Liu H.and Norose K.: "Correlation between direct binding ability of synthetic T.gondii SAG1 peptides to HLA-A2 measuredby a sensor for surface plasmon resonance and antigenicity of the peptides for T.gondii-infected cell-specific CTL." Bioch.Biophysic.Res.Commun.236. 257-261 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Luo W.,Aosai F.,Ueda M.,Yamashita K.,Shimizu K.,Sekiya S.and Yano A.: "Kinetics of changes in parasite load in susceptible and resistant mice infected with an avirulent strain of Toxoplasma godii by using quantitative competitive PCR." J.Parasitol.83(6). 1070-1074 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamashita,K.,Yui,K.,Ueda,M.,and Yano,A.: "CTL-mediated lysis of Toxoplasma-infected target cells does not lead to death of the intracellular parasites." Infect.Immun.60(10). 4651-4655 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aosai F.,Hye-Seong Mun,Norose K.,Mei Chen.Hata H.,Kobayashi M.,Kiuchi M,Stauss H.J.,Yano A.: "Protective immunity induced by vaccination with SAG1-gene transfected cells against Toxoplasma gondii-infection mice." Microbiol.Immunol.43(3). 87-91 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Yano,H-S.Mun.T-H.Yang,H.Hata,M.Kobayashi,K.Norose,S.Hayakawa,Y.Tagawa,Y.Iwakura,S.Nakazaki,Y.Nakazaki,S.Sekiya,A.Yamaura,H.Kubosawa,N.Yumoto,F.Aosai.: "Roles of IFN-gamma in effector mechanisms and pathogenicity of HSPs in mice and human infected with Toxoplasma gondii.〔COPA〔X-9th International Congress of Parasitology,ed.Isao Tada,Somei Kojima,Moriyasu Tsuji." Blogna,Italy.Monduzzi Editore., 10 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] F.aosai,H-S.Mun.T-H.Yang,K.Norose,H.Hata,M.Kobayashi,M.Chen,S.Saito,N.Rikihisa,M.Ichinose,A.Yano.: "HSC70-mediated antigen presentation and ex-vivo gene vaccination with SAG1 to Toxoplasma gondii-infection.〔COPA 〔X-9th International Congress of Parasitology,ed.Isao Tada,Somei Kojima,Moriyasu Tsuji." Blogna,Italy.Monduzzi Editore., 7 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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