| Project/Area Number |
10670320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Iwate Medical University |
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Principal Investigator |
ITAI Kazuyoshi Faculty of Medicine, Iwate Medical University, Assistant Professor, 医学部, 講師 (10048572)
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| Co-Investigator(Kenkyū-buntansha) |
ONODA Toshiyuki Faculty of Medicine, Iwate Medical University, Assistant Professor, 医学部, 講師 (00254748)
野原 勝 岩手医科大学, 医学部, 助手 (60285583)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | fluorides / serum / type I collage carboxy-terminal telopeptides / bone secific alkaline phoshatase / bone mineral density / 血清中フッ素イオン / 骨形成マーカー / 骨吸収マーカー / 微量元素 / 骨粗鬆症 |
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| Research Abstract |
The relation between fluoride and bone metabolism was examined. Fluoride is one of the bone seeker elements. The fluoride concentration in bone increases with the aging, and it is over several hundred ppm in 60 years old and over. It is estimated that the fluoride in bone is discharged in the blood by the change of bone metabolism in the old people, especially in post menopausal women.
The blood was collected from healthy women (258 persons) and it passed over 5 hours after they took the meal. The serum fluoride ion concentrations were measured. The mean 1 standard deviation of fluoride ion concentrations in serum was 7.18±3.23 μg/1. The significant positive correlation was recognized between fluoride ion concentrations in serum and age (p<0.001). Fluoride ion concentrations in serum sharply increased from 5.72±2.07 μg/1 (40's) to 7.82±3.51 μg/1 (50's).
The relation between the fluoride ion concentration in serum and bone metabolism was examined. As the markers of bone metabolism, serum levels of bone specific alkaline phosphatase (B-ALP) which is the marker of bone formation and type I collagen carboxy-terminal telopeptides (ICTP) which is the marker of bone resorption were measured. The significant positive correlation was obtained between fluoride ion concentrations in serum and B-ALP (p<0.Ol) or ICTP (p<0.01) . The significant negative correlation was obtained between fluoride ion concentrations in serum and the bone mineral density of lumbar spine (p<O.Ol). The significant correlations were not obtained when the multiple regression method was performed. This may be caused by that subjects in this study were women with normal lumber bone mineral density. The further study for patients of osteoporosis is necessary.
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