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Cost effectiveness analysis of screening program for colorectal cancer based on the parameters measured in the actual population.

Research Project

Project/Area Number 10670336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHirosaki University

Principal Investigator

SAITO Hiroshi  Hirosaki University, School of medicine, Assistant Professor, 医学部, 講師 (70196004)

Co-Investigator(Kenkyū-buntansha) 坂本 十一  弘前大学, 医学部・附属病院, 助手 (20292146)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Keywordscolorectal cancer / screening / cost-effectiveness / 免疫便潜血検査 / 限界費用 / 費用効果 / 実測値
Research Abstract

Effectiveness of screening program for colorectal cancer (CRC) using guaiac-based fecal occult blood test (FOBT) has been established through randomized controlled trials, but its magnitude is not sufficient. Japanese screening program using immunochemical FOBT is considered to be more effective in terms of mortality reduction. The present study was intended to measure cost effectiveness based on parameters obtained from results of population screening program.
From the analysis of survival status, cause of death, and screening history in 1,145 incident CRC cases during 1986-94 in the study area, fatal cases that were defined as those failed to survive more than 5 years after diagnosis were 10.3% and 26.8% for screen-detected cases and routinely-diagnose cases, respectively. Average duration of survival for fatal cases were 1.85 and 1.54 years in screened group and unscreened group, respectively. Stage distribution of stage O+I, II, IIIa, IIIb, IV were 28.0, 19.7, 28.7 12.8 and 10.8% and 63.6, 13.3, 18.1, 4.2 and 0.8% for routinely-diagnosed and screen-detected cases, respectively. Sensitivity and specificity of immunochemical FOBT were calculated to be 82.5% and 96.6%, respectively. Marginal cost of the program per year of life saved was 807, 287 yen. According to age groups, the costs were calculated to be approximately, 670,000 (870,000), 360,000 (900,000) and 440,000 (650,000) yen for males (females) of 50 to 59, 60 to 69 and 70 to 79 years old, respectively. These results indicate that the present screening program for CRC is highly cost-effective and individuals of 50 years or older is a better target population than those 40 years or older.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Saito H, et al: "A case-control study evaluating occult blood screening for colorectal cancer with Hemoccult test and an immunochemical hemagglutination test."Oncology Reports. 7. 815-19 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito H: "Screening for Colorectal Cancer : current status in Japan."Dis Colon Rectum. 43. 78-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito H, et al: "A case-control study evaluating occult blood screening for colorectal cancer with Hemoccult test and an immunochemical hemagglutination test."Oncology Reports. 7. 815-19 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito H: "Screening for colorectal Cancer : Current status in Japan."Dis colon Rectum. 43. 78-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary

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Published: 1998-04-01   Modified: 2016-04-21  

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