THE STUDY FOR DEVELOPMENT OF QUESTIONNAIRE TO SCREEN PATIENTS WITH NEUROLOGICAL DISEASES FROM LOCAL RESIDENTS

• Project/Area Number: 10670358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: OITA MEDICAL UNIVERSITY
• Principal Investigator: SANNOMIYA Kunihiro OITA MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, RESEARCH ASSOCIATE, 医学部, 助手 (30215925)
• Co-Investigator(Kenkyū-buntansha): KUMAMOTO Toshihide OITA MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (40134936)
• Project Period (FY): 1998 – 1999
• Project Status: Completed (Fiscal Year 1999)
• Budget Amount: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
• Keywords: QUESTIONNAIRE FOR NEUROLOGICAL DISEASE / MULTIPLELACUNA INFARCTION / SCORING / SCREENING FOR NEUROLOGICAL DISORDERS / ELDERLY PEOPLE AT HOME

Research Abstract

Our aim was to develop a questionnaire to screen patients with neurological disease from local residents. First, patients with a lacuna state or multiple lacuna infarctions, which are frequently observed in elderly people, which affects their QOL, were objected. In 1998, we created a scoring system( Lacuna State Score: LSS) that was effective for differentiating patients with LS/MLI. In 1999, using the LSS, we studied patients with LS/MLI and healthy controls( elderly people over sixty, living at home ) in the M town in Kumamoto prefecture. There were 171 selected patients and 865 healthy controls. For extraction of significant factors for the patients group, we compared the subjective neurological symptoms using the χィイD12ィエD1 test, and lifestyle, blood pressure, obesity and various blood tests adjusted for sex and age were compared using the Mantel-Haenszel method between the group of patients and the controls. From the χィイD12ィエD1 test, tinnitus, chillness in extremities, urinary disturbance( P<0.001), abnormality of smell and numbness of extremities( P<0.01), deafness, weakness of extremities, forgetfulness, constipation, visual disturbance, tremors in extremities and gait disturbance( P<0.05 ) were selected as significant factors. With the Mantel-Haenszel test, hypertension( Odds ratio [OR] =8.996 ), obesity( OR= 1.059 ), smoking( OR=7.926 ), drinking( OR=7.640 ), sleep time( OR=7.926 ), value of total cholesterol( OR=0.550 ), ingestion of vegetables( OR=0.608 ) and continuous walking( OR=0.465 ) were selected as significant factors. Using these twenty factors, a questionnaire to screen patients with LS/MLI was made.
However this questionnaire is still insuficient because the sensitivity and selectivity of it are low. Therefore, we think that it is necessary to investigate the propriety of it by applying it to new patients with LS/MLI.